Palifosfamide
Palifosfamide
CAS: 31645-39-3
Molecular Formula: C4H11Cl2N2O2P
Palifosfamide - Names and Identifiers
| Name | Palifosfamide |
| Synonyms | Ipam palifosfamide Palifosfamide Ifosforamide mustard Isophosphamide mustard N,N'-BIS(2-CHLOROETHYL)PHOSPHORODIAMIDATE N,N'-Di-(2-chloroethyl)phosphorodiamidic acid N,N'-Bis(2-chloroethyl)phosphorodiamidic acid |
| CAS | 31645-39-3 |
| InChI | InChI=1/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10) |
Palifosfamide - Physico-chemical Properties
| Molecular Formula | C4H11Cl2N2O2P |
| Molar Mass | 221.02 |
| Density | 1.411 |
| Melting Point | 106-107 ºC |
| Boling Point | 341.5±52.0 °C(Predicted) |
| Flash Point | 160.4°C |
| Vapor Presure | 1.45E-05mmHg at 25°C |
| pKa | 0.79±0.50(Predicted) |
| Storage Condition | -20℃ |
| Refractive Index | 1.497 |
| In vitro study | Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro . The IC 50 ranges from 2.25 ro 6.75 μM for most cell lines except OS222 (IC 50 =31.5 μM). |
| In vivo study | Tumor growth inhibition is seen in both OS31 and OS33 xenografts and the RMS xenograft resulting in a significant difference in event-free survival between the control and the treated groups. Differential gene expression of ALDH3A1 but not ALDH1A1 is noted in the OS31 xenograft. Stabilized palifosfamide administered to mice suppresses MX-1 tumor growth by greater than 80% with 17% complete antitumor responses. Oral bioavailability in rats is 48-73% of parenteral administration, and antitumor activity in mice is equivalent by both routes. Treatment with palifosfamide-tris combined with docetaxelor doxorubicin at optimal regimens results in complete tumor regression in 62-75% of mice. |
Palifosfamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.524 ml | 22.622 ml | 45.245 ml |
| 5 mM | 0.905 ml | 4.524 ml | 9.049 ml |
| 10 mM | 0.452 ml | 2.262 ml | 4.524 ml |
| 5 mM | 0.09 ml | 0.452 ml | 0.905 ml |
Last Update：2024-01-02 23:10:35
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