Panaxadiol
Panaxadiol
CAS: 19666-76-3
Molecular Formula: C30H52O3
Panaxadiol - Names and Identifiers
| Name | Panaxadiol |
| Synonyms | PANAXADIOL Panaxaidol Panaxadiol (20R)-Panaxadiol DAMMARANE-3BETA,12BETA-DIOL 20,25-epoxydammarane-3,12-diol (20R)-20,25-Epoxy-5α-dammarane-3β,12β-diol (3beta,12beta,20R)-20,25-epoxydammarane-3,12-diol |
| CAS | 19666-76-3 |
| InChI | InChI=1/C30H52O3/c1-25(2)13-9-14-30(8,33-25)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-32H,9-18H2,1-8H3 |
Panaxadiol - Physico-chemical Properties
| Molecular Formula | C30H52O3 |
| Molar Mass | 460.73 |
| Density | 1.025±0.06 g/cm3(Predicted) |
| Melting Point | 250℃ |
| Boling Point | 531.3±45.0 °C(Predicted) |
| Flash Point | 275.1°C |
| Solubility | Soluble in methanol, DMSO, acetone and other solvents, insoluble in water. |
| Vapor Presure | 1.65E-13mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Off-White |
| pKa | 14.82±0.70(Predicted) |
| Storage Condition | Refrigerator |
| Sensitive | Sensitive to light |
| Refractive Index | 1.515 |
| MDL | MFCD00210540 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, insoluble in water, derived from ginseng rhizome. |
Panaxadiol - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
Panaxadiol - Reference
| Reference Show more | 1. [IF=5.682] Xuhui Fan et al."Inhibition of JAK2/STAT3 signaling pathway by panaxadiol limits the progression of pancreatic cancer."Aging-Us. 2021 Oct 15; 13(19): 22830–22842 |
Panaxadiol - Reference Information
| plant source: | ginseng |
| biological activity | panaxadiol (Panaxadiol) is a novel anti-tumor drug isolated from traditional Chinese medicine ginseng. |
| use | (20R)-panaxadiol is an active ingredient obtained by microbial transformation, which has the functions of neuroprotection, blood pressure and blood lipid regulation. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: Panaxadiol saponins have pharmacological effects such as anti-myocardial ischemia, anti-lipid peroxidation and immune regulation. |
| production method | 1. the latest preparation method of ginseng extract is as follows: 100g5~6-year-old ginseng is crushed, stirred into mud, 400ml of ethanol with a content of 90% is added, impregnated and stirred for one day and night, filtered, and 300ml of ethanol with a content of 90% is added into the filter residue for second extraction. The two filtrates are combined, and the ethanol is evaporated in the evaporator, leaving about 4g of concentrate. Add 150ml of 60% to the concentrate, stir and dissolve, filter, remove insoluble matter, concentrate the filtrate to 5-10ml and add 60ml of water, extract it 3 times with 80ml of ether in a separatory funnel, merge the ether layer, add 50ml of sodium bicarbonate solution with 6% content, fully oscillate, stand for stratification, take the ether layer, and wash it with distilled water to neutral. Then use the evaporator to remove the ether until the ether is completely distilled, and the result is a ginseng extract. |
Last Update：2024-04-09 20:45:29
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