Phloroglucinol
Phloroglucinol
CAS: 108-73-6
Molecular Formula: C6H6O3
Phloroglucinol - Names and Identifiers
| Name | Phloroglucinol |
| Synonyms | 1,3,5-THB Floroglucin Spasfon-Lyoc Phloroglucin Phloroglucine Floroglucinol Phloroglucinol 1,3,5-Benzenetriol s-Trihydroxybenzene benzene-1,3,5-triol sym-Trihydroxybenzene 1,3,5-Trihydroxybenzene 1,3,5-trihydroxy benzene Phloroglucinol Anhydrous 6,17-alpha Epoxypregnenolone |
| CAS | 108-73-6 |
| EINECS | 203-611-2 |
| InChI | InChI=1/C6H6O3/c7-4-1-5(8)3-6(9)2-4/h1-3,7-9H |
| InChIKey | QCDYQQDYXPDABM-UHFFFAOYSA-N |
Phloroglucinol - Physico-chemical Properties
| Molecular Formula | C6H6O3 |
| Molar Mass | 126.11 |
| Density | 0.801g/mLat 20°C |
| Melting Point | 215-220°C |
| Boling Point | 194.21°C (rough estimate) |
| Flash Point | 14°C |
| Water Solubility | 11.17g/L(room temperature) |
| Solubility | Soluble in diethyl ether, ethanol and pyridine. |
| Vapor Presure | 0.001Pa at 25℃ |
| Appearance | Crystalline Powder |
| Color | White to light beige |
| Merck | 14,7328 |
| BRN | 1341907 |
| pKa | pK1:8.45(0);pK2:8.88(-1) (25°C) |
| Storage Condition | Store below +30°C. |
| Sensitive | Light Sensitive & Hygroscopic |
| Refractive Index | n20/D 1.365 |
| Physical and Chemical Properties |
white or yellowish crystalline or crystalline powder. Melting point 218 °c. Usually with two molecules of crystal water ([6099-90-7]), at 110 °c into anhydrous. Dissolve in 100 parts of water, 10 parts of ethanol, 0.5 parts of pyridine. Soluble in ether. Partial decomposition during sublimation, see light discoloration. Sweet. |
| Use | Determination of antimony, arsenic, cerium, chromate, chromium, gold, iron, Mercury, nitrite, osmium, palladium, tin, vanadium, vanillin and lignin, determination of furfural, pentose, pentose, methanol, Chloral Hydrate, turpentine, lignocellulosic tissue and hydrochloric acid in gastric juice, decalcification of bone specimens. |
Phloroglucinol - Risk and Safety
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns R43 - May cause sensitization by skin contact |
| Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 1170 3/PG 2 |
| WGK Germany | 2 |
| RTECS | SY1050000 |
| TSCA | Yes |
| HS Code | 29072900 |
| Toxicity | LD50 in mice, rats (g/kg): 4.7, 4.0 i.g. (Cahen) |
Phloroglucinol - Reference Information
| LogP | 0.55 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | phloroglucinol (1,3, 5-trihydroxybenzene) is an important fine chemical product, intermediates mainly used in the synthesis of drugs, such as flavonoids. As a drug for the treatment of cardiovascular and cerebrovascular diseases, flavonoids have been paid more and more attention by pharmacologists. |
| pharmacological use | The ATC code of phloroglucinol is A03AX12, which can treat functional intestinal diseases and gastrointestinal diseases such as cholelithiasis. The acylated pyrogallol can also be used as an inhibitor of fatty acid synthase. The common form of drug injection, injection in addition to pyrogallol as the active ingredient, there are trimethylphloroglucinol, sodium chloride, sodium bisulfite, citric acid, disodium hydrogen phosphate dodecahydrate and other accessories. |
| characteristic reaction of phloroglucinol | formaldehyde reacts with phloroglucinol to form orange compounds under alkaline conditions, the colorimetric determination was carried out at the maximum absorption wavelength of 460nm, which was used to detect the low trace amount of formaldehyde in textile clothing. since phloroglucinol can undergo enol-and ketone-type tautomerism, it can react with ammonia as follows: Under the action of ammonia, phloroglucinol can be obtained by ketone-type reaction, in the aqueous solution of the acid, the amine is hydrolyzed to obtain phloroglucinol. |
| safety | There were 39 clinical trials to observe the safety and tolerability of phloroglucinol, of the 2598 patients treated with phloroglucinol, only very few patients reported occasional dizziness! Nausea and other adverse reactions, but these symptoms will disappear after stopping or reducing the dose, rarely have allergic reactions, such as rash! Zang measles, etc., it has no teratogenicity and mutagenicity, and years of clinical application results show that it does not have any adverse effects on the mother and fetus, demonstrate the safety of its application in the field of gynecology. All patients who have been administered intramuscularly and intravenously, good compliance to phloroglucinol. Long-term medication and high-dose medication safety are also good-because phloroglucinol does not have atropine-like adverse reactions, it is also safe for patients with glaucoma and prostatic hypertrophy. |
| Use | determination of antimony, arsenic, cerium, chromate, chromium, gold, iron, Mercury, nitrite, osmium, palladium, tin, vanadium, vanillin and lignin, determination of furfural, pentose, pentose, methanol, Chloral Hydrate, turpentine, lignocellulosic tissue and gastric juice hydrochloric acid, decalcification of bone specimens. used as a Biological reagent = dye, and used to test vanilloid, lignin, determination of furfural, pentose, etc. determination of antimony, arsenic, cerium, chromate, chromium, gold, iron, Mercury, nitrite, osmium, palladium, tin, vanadium, vanillin and lignin. The free acid (hydrochloric acid) in pentose, aldehydes, lignin, hydrochloric acid, methanol, Chloral Hydrate, turpentine, lignocellulosic tissue and gastric juice was determined. Decalcification of bone specimens. |
| production method | 2,4, 6-trinitrobenzoic acid is reduced with tin particles to obtain 2,4, 6-triaminobenzoic acid, the dilute solution of which was heated to reflux for 20h, acidified with hydrochloric acid, and cooled to crystallize to obtain phloroglucinol. The yield was 46-53%. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 4000 mg/kg; Oral-mouse LD50: 4550 mg/kg |
| flammability hazard characteristics | stimulus smoke from open flame combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| fire extinguishing agent | carbon dioxide, foam, sand, water mist |
Last Update：2024-04-09 21:04:16
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