Prednisone
prednisone
CAS: 53-03-2
Molecular Formula: C21H26O5
Prednisone - Names and Identifiers
| Name | prednisone |
| Synonyms | Cortan Colisone Bicortone Ancortone prednisone Prednisone 1,2-Dehydrocortisone 11,20-trione,17,21-hydroxy-pregna-4-diene-3 11,20-trione,17,21-dihydroxy-pregna-4-diene-3 1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione 17-alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione (8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione |
| CAS | 53-03-2 |
| EINECS | 200-160-3 |
| InChI | InChI=1/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14?,15?,18?,19-,20-,21-/m0/s1 |
Prednisone - Physico-chemical Properties
| Molecular Formula | C21H26O5 |
| Molar Mass | 358.43 |
| Density | 1.1121 (rough estimate) |
| Melting Point | 236-238°C(lit.) |
| Boling Point | 410.86°C (rough estimate) |
| Specific Rotation(α) | 169 º (c=0.5, dioxane) |
| Flash Point | >200℃ |
| Water Solubility | 115mg/L(25 ºC) |
| Solubility | Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9). |
| Vapor Presure | 1.51E-15mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Merck | 7722 |
| BRN | 2065301 |
| pKa | 12.36±0.60(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 170 ° (C=0.5, Dioxan |
| Physical and Chemical Properties | White or off-white crystalline powder, no odor, slightly bitter taste. Practically insoluble in water, slightly soluble in ethanol (1:190) and chloroform (1:200). Mp233-235 C (decomposition), than the optical rotation [alpha] 25D 172 degrees (dioxane), the product of acetic acid solution at 240nm wavelength has the maximum absorption. |
| Use | Commonly used in combination chemotherapy, can improve the general condition of patients, can also be used for acute leukemia and other tumors |
Prednisone - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R63 - Possible risk of harm to the unborn child |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. |
Prednisone - Standard
Authoritative Data Verified Data
This product is 17a ,21-dihydroxyprogestin -1, 4-diene-3, 11, 20-trione. The content of C21H2605 shall be 97.0% ~ 102.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
Prednisone - Trait
Authoritative Data Verified Data
- This product is white or white crystalline powder; Odorless.
- This product is slightly soluble in ethanol or chloroform, and is almost insoluble in water.
specific rotation
take this product, precision weighing, plus dioxane dissolution and quantitative dilution of about 5mg per lml solution, according to the law (General 0621), the specific rotation was 167 ° to 175 °.
absorption coefficient
take this product, precision weighing, plus ethanol dissolution and quantitative dilution to make a solution containing about 15ug per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 240nm, and the absorption coefficient was 405 to 435.
Last Update：2022-01-01 13:38:07
Prednisone - Differential diagnosis
Authoritative Data Verified Data
- take about 5mg of this product, add 2ml sulfuric acid to dissolve it, and place it for 5 minutes to show orange color; Pour this solution into 10ml water, and the solution will turn yellow and gradually turn blue-green.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 612).
Last Update：2022-01-01 13:38:08
Prednisone - Exam
Authoritative Data Verified Data
Related substances
take this product, precision weighing, adding mobile phase to dissolve and quantitatively dilute to make a solution containing about 0.5mg per lml as a test solution; Take 1ml for precision measurement, in a 100ml measuring flask, dilute to the scale with the mobile phase, shake well, and use as a control solution; Take the cortisone control, dissolve and quantitatively dilute with the mobile phase to make a solution containing about 5ug per 1ml, as a control solution. According to the chromatographic conditions under the content determination item, 20ul of each of the test solution, the control solution and the reference solution are accurately measured and injected into the human liquid chromatograph respectively, the chromatogram was recorded to 2.5 times of the retention time of the main component peak. If there are peaks in the chromatogram of the test solution that are consistent with the retention time of the pine peak in the chromatogram of the reference solution, the peak area shall be calculated according to the external standard method, and shall not exceed 0.5%; other single impurity peak area shall not be greater than 0.5 times (0.5%) of the main peak area of the control solution, and the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.01 times smaller than the main peak area of the control solution were ignored.
loss on drying
take about 0.5g of this product, dry at 105°C for 3 hours, and lose no more than 1.0% of weight (General rule 0831).
Last Update：2022-01-01 13:38:09
Prednisone - Content determination
Authoritative Data Verified Data
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Acetonitrile-water (24:76) as mobile phase; Detection wavelength of 240mn. Prednisone and cortisone were taken, dissolved and diluted with mobile phase to make a solution containing about 5ug of each lml. 20ul was injected into human liquid chromatograph and the chromatogram was recorded, the degree of separation between prednisone peak and cortisone peak should be greater than 3.4.
- determination of this product, precision weighing, plus mobile phase dissolution and quantitative dilution of about 50% per 1 mL solution, as a test solution, A 20ul injection liquid chromatograph was used to record the chromatogram. Another prednisone reference substance was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 13:38:09
Prednisone - Category
Authoritative Data Verified Data
adrenocortical hormone drugs.
Last Update：2022-01-01 13:38:09
Prednisone - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 13:38:10
Supplier List
Featured ProductsSpot supply
Product Name: Prednisone Request for quotationCAS: 53-03-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Prednisone Visit Supplier Webpage Request for quotationCAS: 53-03-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Dehydrocortisone (Standard) Visit Supplier Webpage Request for quotationCAS: 53-03-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: prednisone Request for quotation
CAS: 53-03-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 53-03-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Featured ProductsSpot supply
Product Name: Prednisone Request for quotationCAS: 53-03-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Prednisone Visit Supplier Webpage Request for quotationCAS: 53-03-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Dehydrocortisone (Standard) Visit Supplier Webpage Request for quotationCAS: 53-03-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: prednisone Request for quotation
CAS: 53-03-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 53-03-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
View History