Ps48
PS 48
CAS: 1180676-32-7
Molecular Formula: C17H15ClO2
Ps48 - Names and Identifiers
Ps48 - Physico-chemical Properties
| Molecular Formula | C17H15ClO2 |
| Molar Mass | 286.75 |
| Density | 1.225±0.06 g/cm3(Predicted) |
| Melting Point | 114-115℃ |
| Boling Point | 444.1±24.0 °C(Predicted) |
| Solubility | DMSO: >20mg/mL |
| Appearance | powder |
| Color | white to off-white |
| pKa | 4.55±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Use | PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1). |
Ps48 - Risk and Safety
| WGK Germany | 3 |
Ps48 - Reference
| Reference Show more | 1. Hindie V, et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64.2. Han F, et al. Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. Int J Biol Sci. 2017 Sep 21;13(10):1266-1275. |
Ps48 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.487 ml | 17.437 ml | 34.873 ml |
| 5 mM | 0.697 ml | 3.487 ml | 6.975 ml |
| 10 mM | 0.349 ml | 1.744 ml | 3.487 ml |
| 5 mM | 0.07 ml | 0.349 ml | 0.697 ml |
Last Update：2024-01-02 23:10:35
Ps48 - Cell Experiment
Human renal mesangial cells (HRMCs) are cultured with 1640 media, containing 10% fetal bovin serum at 37 °C in 5% CO2. Cells are cultured with D-glucose at normal (5.5 mM) or high (25 mM) concentrations in serum-free medium. D-Mannitol (25 mM) is used for a control of osmolality. TP is reconstituted in 0.01% DMSO and freshly diluted with culture medium to 10 ug/L before using. To determine the specific role of PDK1 in TP-potentiated anti-proliferation, 5 μM PS48 (MedChem Express, USA) is applied following the treatment of TP. MTT assay is used to detect cell proliferation. HRMCs are seeded at a density of 1x105/mL into 96-well plates. After 12, 24, 48 and 72 h incubation with different compounds, 20 uL MTT (5 mg/mL) is added to each well. Cells are then cultured for an additional 2 h and subsequently lysed using DMSO (150 uL/well). When the formazan crystals completely dissolve, the optical density (OD) is measured at 570 nm. The arithmetic mean OD of six wells for each group is calculated.
Last Update：2023-08-16 21:32:38
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