Pyrrolidine
Pyrrolidine
CAS: 123-75-1
Molecular Formula: C4H9N
Pyrrolidine - Names and Identifiers
| Name | Pyrrolidine |
| Synonyms | Azolidine Prolamine Pyrrolidin Pyrrolidine Pyrrolidene Butylenimine perhydroazole pyrrolidinium Azacyclopentane pyrrolidinering Perhydropyrrole tetrahydroazole Tetrahydropyrrol Tetramethylenimin 1-AZACYCLOPENTANE AKOS BBS-00003603 Tetrahydropyrrole Tetrahydro-pyrrole Tetramethylenimine PYRROLIDINE,REAGENT TETRAMETHYLENEIMINE Pyrrole, tetrahydro- pyrrolidine,tetrahydropyrrole TETRAHYDROPYRROLE(PYRROLIDINE) |
| CAS | 123-75-1 |
| EINECS | 204-648-7 |
| InChI | InChI=1/C4H9N/c1-2-4-5-3-1/h5H,1-4H2/p+1 |
| InChIKey | RWRDLPDLKQPQOW-UHFFFAOYSA-N |
Pyrrolidine - Physico-chemical Properties
| Molecular Formula | C4H9N |
| Molar Mass | 71.12 |
| Density | 0.852 g/mL at 25 °C (lit.) |
| Melting Point | -63 °C |
| Boling Point | 87-88 °C/760 mmHg (lit.) |
| Flash Point | 37°F |
| JECFA Number | 1609 |
| Water Solubility | Miscible with alcohol, ether, chloroform and water. |
| Solubility | water: miscible |
| Vapor Presure | 128 mm Hg ( 39 °C) |
| Vapor Density | 2.45 (vs air) |
| Appearance | Liquid |
| Color | Colorless to Almost colorless |
| Merck | 14,8015 |
| BRN | 102395 |
| pKa | 11.27(at 25℃) |
| PH | 12.9 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable; flammable. Incompatible with strong acids, strong oxidizing agents. |
| Sensitive | Air Sensitive |
| Explosive Limit | 1.6-10.6%(V) |
| Refractive Index | n20/D 1.443(lit.) |
| Physical and Chemical Properties |
|
| Use | For the preparation of drugs, fungicides, insecticides, etc |
Pyrrolidine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R22 - Harmful if swallowed R23 - Toxic by inhalation R34 - Causes burns R35 - Causes severe burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S33 - Take precautionary measures against static discharges. |
| UN IDs | UN 1922 3/PG 2 |
| WGK Germany | 2 |
| RTECS | UX9650000 |
| FLUKA BRAND F CODES | 34 |
| TSCA | Yes |
| HS Code | 2933 99 80 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 433 mg/kg |
Pyrrolidine - Nature
Open Data Verified Data
colorless transparent liquid, with special smell, see light or humid air is easy to change yellow, soluble in water, ethanol. Corrosive and flammable. Density 0. 866, melting point -63 ℃, boiling point 86~88 ℃, refractive index 1. 4421~1.4441, flash point 3 ℃. Miscible with water, soluble in ethanol, ether, chloroform.
Last Update：2025-06-10 22:55:16
Pyrrolidine - Preparation Method
Open Data Verified Data
derived from the hydrogenation of peroxon.
Last Update：2022-01-01 10:56:41
Pyrrolidine - Application
Open Data Verified Data
pharmaceutical raw materials, organic synthesis, special organic solvents; Used in the preparation of drugs, fungicides, insecticides, etc.
Last Update：2025-08-19 16:24:40
Pyrrolidine - Reference Information
| FEMA | 3523 | PYRROLIDINE |
| LogP | 0.22 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | tetrahydropyrrole, chemical formula is C4H9N, is a colorless or yellow liquid, has a special odor, see light or humid air, yellow, soluble in water, ethanol, corrosive and flammable. |
| properties | tetrahydropyrrole is a cyclic secondary amine, colorless transparent liquid with special odor, light or wet air to yellow, soluble in water and ethanol, corrosive and flammable. |
| Application | pyrrolidine has the properties and reactions of common amines. It has a wide range of applications in the fields of medicine, food, pesticides, daily chemicals, coatings, textile, printing and dyeing, paper making, photosensitive materials, polymer materials, desulfurization agents, zeolite template materials and so on. |
| pyrrolidine | also known as pyrrolidine pyrrolidine, colorless to yellowish liquid, irritating ammonia odor, smoke in the air, toxic. The relative density of 0.8618, boiling point 88~89 deg C, refractive index of 1.4402(28 deg C). Strong alkaline, miscible with water, soluble in ethanol, ether, chloroform. pyrrolidine can be synthesized by catalytic hydrogenation of pyrrole. Pyrrolidine is a natural substance existing in tobacco and carrot leaves. The molecular structure of pyrrolidine is a cyclic secondary amine, and its reaction is the same as that of common amines. Pyrrolidine is an important organic chemical raw material, which can be used for the preparation of drugs, fungicides, insecticides and so on. preparation method: ① pyrrolidine can be obtained by using 1, 4-butanediol as a raw material, dehydrating, generating Tetrahydrofuran, and then reacting with ammonia. ② tetrahydropyrrole can be obtained by reacting furan with ammonia at 400 ℃ under the action of catalyst. ③ pyrrolidine can be obtained by reacting 1, 4-dichlorobutane with ammonia. (4) with pyrrole as raw material, ruthenium or rhodium as catalyst, reduction, can be prepared by pyrrolidine. |
| Use | pharmaceutical raw materials, organic synthesis, special organic solvents. organic synthesis. Pesticides. Fungicide. Epoxy resin curing agent. Rubber accelerators. Inhibitors. for the preparation of drugs, fungicides, insecticides, etc. |
| production method | 1. In the butanediol method, γ-butyrolactone is prepared by dehydrogenation and re-amination, and the reaction scheme is as follows: 2. Maleic anhydride method using maleic anhydride as raw material, obtained by one-step hydrogenation and ammonification, the reaction formula is as follows: |
| category | flammable liquid |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 300 mg/kg; Oral-mouse LD50: 450 mg/kg |
| flammability hazard characteristics | in case of fire, high temperature, oxidant flammable; toxic nitric oxide gas generated by heat |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| Occupational Standard | SEL 0.1 mg/m3 |
| spontaneous combustion temperature | 653 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:44
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