RGX-104
RGX-104
CAS: 610318-03-1
Molecular Formula: C34H34Cl2F3NO3
RGX-104 - Names and Identifiers
RGX-104 - Physico-chemical Properties
| Molecular Formula | C34H34Cl2F3NO3 |
| Molar Mass | 632.55 |
| Solubility | DMSO : 150 mg/mL (237.14 mM; ultrasonic and warming and heat to 60°C) |
| Storage Condition | -20°C |
| In vitro study | RGX-104, an orally administered LXR agonist, potently induces ApoE expression, resulting in endogenous immune-mediated antitumor activity. RGX-104 drives anti-tumor immune responses by modulating the abundance and activity of myeloid-derived suppressor cells and dendritic cells. |
| In vivo study | In several syngenic xenograft tumor models, RGX-104 monotherapy elicits a tumor response, including melanoma, ovarian cancer, lung cancer, and glioblastoma multiforme. This antitumor activity via activation of LXR is associated with constitutive upregulation of ApoE expression. |
RGX-104 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.581 ml | 7.905 ml | 15.809 ml |
| 5 mM | 0.316 ml | 1.581 ml | 3.162 ml |
| 10 mM | 0.158 ml | 0.79 ml | 1.581 ml |
| 5 mM | 0.032 ml | 0.158 ml | 0.316 ml |
Last Update：2024-01-02 23:10:35
RGX-104 - Reference Information
| biological activity | RGX-104 is an orally active liver X receptor agonist, endogenous immune responses can be regulated by transcriptional activation of the ApoE gene. |
| Target | Value |
Last Update：2024-04-09 20:49:11
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Product Name: (R)-2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)butoxy)phenyl)aceticacidhydrochloride Request for quotationCAS: 610318-03-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
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Product Name: RGX-104HCl Visit Supplier Webpage Request for quotationCAS: 610318-03-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Abequolixron hydrochloride Visit Supplier Webpage Request for quotationCAS: 610318-03-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: RGX-104 Visit Supplier Webpage Request for quotationCAS: 610318-03-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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