RI-1
RI-1
CAS: 415713-60-9
Molecular Formula: C14H11Cl3N2O3
RI-1 - Names and Identifiers
RI-1 - Physico-chemical Properties
| Molecular Formula | C14H11Cl3N2O3 |
| Molar Mass | 361.61 |
| Density | 1.61 |
| Boling Point | 483.0±45.0 °C(Predicted) |
| Solubility | DMSO 50 mg/mL;Water <1 mg/mL; EtOH <1 mg/mL |
| Appearance | powder |
| Color | yellow to orange |
| pKa | -3.45±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Use | The RI-1 is a RAD51 inhibitor with an IC50 of 5 to 30 μM. |
| In vitro study | RI-1 by direct and specific destruction of HsRAD51 and inhibition of RAD51, the ability to form single-stranded DNA filaments, increase the sensitivity of cells to DNA damage. In addition, MCF-7 of all three cancer cell lines (HeLa cells, RI-1 and U2OS) produced single-dose toxicity alone with LD50 values in the 20-40 micron range. RI-1 reduced γ-H2AX foci in G2 cells and resulted in an increase in unrepaired DNA double-strand breaks 6 hours after irradiation. |
| In vivo study | RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice. Animal Model: Female BALB/c nude mice (6 weeks) bearing TNBC tumor Dosage: 50 mg/kg Administration: I.p. every 3 days for 30 days Result: Resulted in significant inhibition of tumor growth. Did not cause body weight loss significantly. |
RI-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.765 ml | 13.827 ml | 27.654 ml |
| 5 mM | 0.553 ml | 2.765 ml | 5.531 ml |
| 10 mM | 0.277 ml | 1.383 ml | 2.765 ml |
| 5 mM | 0.055 ml | 0.277 ml | 0.553 ml |
Last Update：2024-01-02 23:10:35
RI-1 - Reference Information
| Biological activity | RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with an IC50 of 5 to 30 µM. |
| target | TargetValue RAD51 <30 μM |
| Target | Value |
| RAD51 | <30 μM |
| in vitro study | RI-1 the ability to form single-stranded DNA filaments and improve the sensitivity of cells to DNA damage by directly and specifically destroying HsRAD51 and inhibiting RAD51. In addition, in all three cancer cell lines (HeLa cells, MCF-7 and U2OS), RI-1 single-dose toxicity alone, LD50 values are in the 20-40 micrometer range. RI-1 reduced γ-H2AX foci in G2 phase cells and resulted in an increase in unrepaired DNA double-strand breaks after 6 h of irradiation. |
| in vivo study | RI-1 (50 mg/kg; I.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumour growth in mice. Animal model: female balb/c nude mice (6 weeks) bearing TNBC tumour Dosage: 50 mg/kg Administration: I.p. every 3 days for 30 days result: Resulted in significant inhibition of tumor growth. did not cause body weight loss significantly. |
| Animal Model: | Female BALB/c nude mice (6 weeks) bearing TNBC tumor |
| Dosage: | 50 mg/kg |
| Administration: | I.p. every 3 days for 30 days |
| Result: | Resulted in significant inhibition of tumor growth. Did not cause body weight loss significantly. |
Last Update：2024-04-09 22:09:11
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Mobile: +86-18621343501
QQ: 2881950922
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Product Name: RI-1 Visit Supplier Webpage Request for quotationCAS: 415713-60-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: RI-1 Visit Supplier Webpage Request for quotation
CAS: 415713-60-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 415713-60-9
Tel: 18301782025
Email: 3008007409@qq.com
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