RSL3
RSL3
CAS: 1219810-16-8
Molecular Formula: C23H21ClN2O5
RSL3 - Names and Identifiers
RSL3 - Physico-chemical Properties
| Molecular Formula | C23H21ClN2O5 |
| Molar Mass | 440.88 |
| Density | 1.368±0.06 g/cm3(Predicted) |
| Boling Point | 641.3±55.0 °C(Predicted) |
| Appearance | Form solid, color Off-white |
| pKa | 16.09±0.60(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Physical and Chemical Properties | Bioactive RSL3 ((1S,3R)-RSL3) is a ferroptosis activator, independent of VDAC, and selective for tumor cells carrying tumorigenic RAS. It binds and inactivates GPX4, mediating iron death regulated by GPX4. |
RSL3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
RSL3 - Nature
| Solubility | Soluble in DMSO (45 mg/ml) |
Last Update：2024-04-10 22:29:15
RSL3 - Uses and synthesis methods
Target
Target Value
Gpx4
(In Calu-1 cells)
in vitro studies
Compounds that can induce iron death inactivate GPX4 by directly binding or reducing glutathione. Combined with GPX4, RSL3 inactivates GPX4 and induces the generation of reactive oxygen species induced by lipid peroxidation. RSL3 can induce synergistic death with tumorigenic RAS very quickly and effectively. Low concentration (10 ng/ml)RSL3 inhibited the growth of BJ-TERT/LT/ST/RASV12 and DRD cells, killing sensitive cells 8 hours after treatment.
In vivo studies
Prostaglandin endoperoxide synthase (PTGS) is a key enzyme in prostaglandin synthesis. Constitutive PTGS1 and inducible PTGS2 are two isozymes of PTGS. In mice, COX-2 levels encoded by PTGS2 can be significantly up-regulated after treatment with RSL3 and erastin.
Last Update：2024-04-10 22:29:15
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