Rilpivirine
4-[4-[4-[(E)-2-Cyanovinyl]-2,6-dimethylphenylamino]pyrimidin-2-ylamino]benzonitrile
CAS: 500287-72-9
Molecular Formula: C22H18N6
Rilpivirine - Names and Identifiers
Rilpivirine - Physico-chemical Properties
| Molecular Formula | C22H18N6 |
| Molar Mass | 366.42 |
| Density | 1.27 |
| Melting Point | 245℃ |
| Boling Point | 634.1±65.0 °C(Predicted) |
| Flash Point | 337.3°C |
| Solubility | Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly |
| Vapor Presure | 5.56E-16mmHg at 25°C |
| Appearance | Solid |
| Color | Yellow |
| pKa | 4.56±0.10(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.665 |
| In vitro study | Rilpivirine exhibits antiviral activity against wild-type and selective site single and double HIV-1 mutants, with EC50 ranging from 0.1 nM to 2 nM. Rilpivirine inhibits viral replication, the first generation of NNRTIs does not inhibit the concentration of replication, and creates a high genetic barrier to hinder development. |
| In vivo study | After intravenous injection of Rilpivirine, the elimination half-life ranges from 4.4 hours in rats to 31 hours in dogs. After oral administration of the PEG 400 of Rilpivirine, the Half-Life range is 2.8 Hours in rats and 39 hours in dogs. |
Rilpivirine - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.729 ml | 13.646 ml | 27.291 ml |
| 5 mM | 0.546 ml | 2.729 ml | 5.458 ml |
| 10 mM | 0.273 ml | 1.365 ml | 2.729 ml |
| 5 mM | 0.055 ml | 0.273 ml | 0.546 ml |
Last Update：2024-01-02 23:10:35
Rilpivirine - Reference Information
| introduction | lipiavirin is a non-nucleoside reverse transcriptase inhibitor, usually used in combination with other antiretroviral drugs to treat human immunodeficiency virus (HIV) infection. The use of ribavirin may cause a short increase in serum aminotransferase in a few patients, and clinically obvious acute liver injury may occur in rare patients. |
| biological activity | Rilpivirine (R278474, TMC27, DB08864) is a non-nucleoside reverse transcription inhibitor (NNRTI) and is used to treat HIV-1 infection. |
| Target | Value |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 19:05:12
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