SERTINDOLE
SERTINDOLE
CAS: 106516-24-9
Molecular Formula: C24H26ClFN4O
SERTINDOLE - Names and Identifiers
SERTINDOLE - Physico-chemical Properties
| Molecular Formula | C24H26ClFN4O |
| Molar Mass | 440.94 |
| Density | 1.36 |
| Melting Point | 95-100°C |
| Boling Point | 592.1±50.0 °C(Predicted) |
| Appearance | Form solid, color off-white |
| pKa | 14.53±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Physical and Chemical Properties | The chemical properties are crystallized from acetone with a melting point of 154~155 ℃; Or crystallized from isopropanol-ethyl acetate with a melting point of 166 ℃. |
| Use | The use is 5HT2-antagonist. For the treatment of schizophrenia. |
SERTINDOLE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | NJ0621100 |
SERTINDOLE - Upstream Downstream Industry
SERTINDOLE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.268 ml | 11.339 ml | 22.679 ml |
| 5 mM | 0.454 ml | 2.268 ml | 4.536 ml |
| 10 mM | 0.227 ml | 1.134 ml | 2.268 ml |
| 5 mM | 0.045 ml | 0.227 ml | 0.454 ml |
Last Update：2024-01-02 23:10:35
SERTINDOLE - Nature
| Solubility | DMSO: >10mg/mL |
Last Update：2024-04-10 22:29:15
SERTINDOLE - Uses and synthesis methods
biological activity
Sertindole are 5-HT2A,5-HT2C,D2 and αl receptor antagonists.
Target
5-HT 2A Receptor
5-HT 2C Receptor
Production method
After the Grignard reaction between the compound (I) and the compound (II), the product (III) is hydrolyzed to obtain the product.
Last Update：2024-04-09 21:01:54
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View History
Raw Materials for SERTINDOLE
5-CHLORO-1-(4-FLUORO-PHENYL)-3-(1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1H-INDOLE
1-(2-Chloroethyl)imidazolidin-2-one
5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE
5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE
4-oxopiperidinium chloride
1-(2-Chloroethyl)imidazolidin-2-one
5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE
5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE
4-oxopiperidinium chloride