SMILAGENIN
Smilagenin
CAS: 126-18-1
Molecular Formula: C27H44O3
SMILAGENIN - Names and Identifiers
SMILAGENIN - Physico-chemical Properties
| Molecular Formula | C27H44O3 |
| Molar Mass | 416.64 |
| Density | 1.0362 (rough estimate) |
| Melting Point | ~185°C |
| Boling Point | 474.91°C (rough estimate) |
| Specific Rotation(α) | D25 -69° (c = 0.5 in chloroform) |
| pKa | 15.14±0.70(Predicted) |
| Storage Condition | RT, dark |
| Refractive Index | 1.4700 (estimate) |
SMILAGENIN - Risk and Safety
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
SMILAGENIN - Reference Information
| biological activity | Smilagenin (SMI) is a small, from anemarrhenae and geranium Radix asparagi, it is widely used in the study of chronic neurodegenerative diseases. Smilagenin (SMI) improves memory in aged rats by increasing the density of muscarinic receptor subtype 1 (M1)-receptors. Smilagenin (SMI) attenuates Aβ (25-35)-induced neurodegeneration by stimulating brain-derived neurotrophic factor gene expression and is useful in AD studies. |
| Cell Line: | SH-SY5Y cells SH-SY5Y cells |
| Concentration: | 10 μM 10 μM |
| Incubation Time: | 24 hours 24 hours |
| Result: | Elevated the SH-SY5Y cell viability. Increased GDNF and BDNF transcription. Ameliorated locomotor ability of MPTP/probenecid-lesioned mice. |
| Animal Model: | MPTP/probenecid-induced mouse model |
| Dosage: | 10 or 26 mg/kg |
| Administration: | Intragastric administration; 10 or 26 mg/kg; once daily; 60 days |
Last Update：2024-04-09 21:32:10
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Spot supply
Product Name: Smilagenin Visit Supplier Webpage Request for quotationTel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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