SUC-LEU-LEU-VAL-TYR-AMC
SUC-LEU-LEU-VAL-TYR-AMC
CAS: 94367-21-2
Molecular Formula: C40H53N5O10
SUC-LEU-LEU-VAL-TYR-AMC - Names and Identifiers
SUC-LEU-LEU-VAL-TYR-AMC - Physico-chemical Properties
| Molecular Formula | C40H53N5O10 |
| Molar Mass | 763.88 |
| Density | 1.249±0.06 g/cm3(Predicted) |
| Boling Point | 1116.8±65.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 20 mg/ml), or in DMF (up to 10 mg/ml) |
| Appearance | Lyophilized solid |
| Color | White to Off-White |
| pKa | 4.69±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month. |
| In vitro study | Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY) is a membrane-permeable calpain-specific fluorogenic substrate, pteolytic hydrolysis of the peptidyl-7-amino bond liberates the highly fluorescent 7-amino-4-methylcoumarin (AMC) moiety. The effect of TGF-β on hydrolysis of these substrates (e.g Suc-Leu-Leu-Val-Tyr-AMC) are assessed. Biliary epithelial H69 cells are incubated with 10, 1, 0.1, or 0 ng/mL TGF-β for 24 h. Substrate hydrolysis is then fluorometrically assessed in cytosolic extracts. Basal activity is 1.12, 8.33, and 14.52 nmol AMC/mg protein/min for suc-LLVY-AMC, z-LLE-AMC, and z-LLL-AMC hydrolysis, respectively. |
SUC-LEU-LEU-VAL-TYR-AMC - Risk and Safety
| WGK Germany | 3 |
SUC-LEU-LEU-VAL-TYR-AMC - Reference Information
| biological activity | Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate. |
| in vitro research | Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY) is a membrane-permeable calpain-specific fluorogenic substrate, pteolytic hydrolysis of the peptidyl-7-amino bond liberates the highly fluorescent 7-amino-4-methylcurrin (AMC) moiety. The effect of TGF-β on hydrolysis of these substrates (e.g Suc-Leu-Leu-Val-Tyr-AMC) are assessed. Biliary epithelial H69 cells are incubated with 10, 1, 0.1, or 0 ng/mL TGF-β for 24 h. Substrate hydrolysis is then fluorometrically assessed in cytosolic extracts. Basic activity is 1.12, 8.33, and 14.52 nmol AMC/mg protein/min for suc-LLVY-AMC, z-LLE-AMC, and z-LLL-AMC hydrolysis, respectively. |
Last Update：2024-04-09 21:11:58
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Product Name: Suc-Leu-Leu-Val-Tyr-AMC (solution) Visit Supplier Webpage Request for quotationCAS: 94367-21-2
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