Seocalcitol
Seocalcitol
CAS: 134404-52-7
Molecular Formula: C30H46O3
Seocalcitol - Names and Identifiers
Seocalcitol - Physico-chemical Properties
| Molecular Formula | C30H46O3 |
| Molar Mass | 454.68 |
| Density | 1.06±0.1 g/cm3(Predicted) |
| Melting Point | 123-125° |
| Boling Point | 608.5±55.0 °C(Predicted) |
| pKa | 14.29±0.29(Predicted) |
| Storage Condition | Store at -20°C |
| In vitro study | Seocalcitol (EB 1089) is a stimulators of osteoclast recruitment in murine bone marrow cultures, with EC 50 at 0.1 nM. Seocalcitol stimulates bone resorption with an estimated EC 50 at 0.03 nM. Seocalcitol (EB 1089) elicites a dose-dependent induction of 24-hydroxylase mRNA in the kidney (EC 50 =0.4±0.13). In the kidney, K d values for Seocalcitol is 0.48±0.04 nM. However, in the intestine, the K d for Seocalcitol is 1.43±0.19 nM). Seocalcitol (0.1-10 nM) induces cell differentiation in a dosedependent manner. A higher differentiating activity is observed for 1 nM Seocalcitol (EB 1089) than for 1 nM VD 3 . |
| In vivo study | Seocalcitol (EB1089), a synthetic vitamin D analog, exhibits reduced hypercalcemic activity relative to 1,25(OH) 2 VD 3 . In another study, long-term intraperitoneal (IP) administration of Seocalcitol at a dose of 0.5 μg/kg body weight every other day in C3H/Sy mice exertes a very strong inhibitory effect on hepatocellular carcinoma (HCC) development. Seocalcitol (EB 1089) is administered daily to postnatal rats from 4 to 12 days of age (P4 to P12) by intraperitoneal injection at either 0.38 or 1.25 μg/kg body weight (BW)/day. Only the highest dose of Seocalcitol (1.25 μg/kg BW) causes a significant reduction in weight gain when administered alone or in conjunction with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid. |
Seocalcitol - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.199 ml | 10.997 ml | 21.993 ml |
| 5 mM | 0.44 ml | 2.199 ml | 4.399 ml |
| 10 mM | 0.22 ml | 1.1 ml | 2.199 ml |
| 5 mM | 0.044 ml | 0.22 ml | 0.44 ml |
Last Update：2024-01-02 23:10:35
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