Sibutramine
Sibutramine
CAS: 106650-56-0
Molecular Formula: C17H27Cl2N
Sibutramine - Names and Identifiers
| Name | Sibutramine |
| Synonyms | Sibutramine 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethyl-butan-1-amine N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N'-dimethylamine |
| CAS | 106650-56-0 |
| InChI | InChI=1/C17H26ClN.ClH/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;/h6-9,13,16H,5,10-12H2,1-4H3;1H |
Sibutramine - Physico-chemical Properties
| Molecular Formula | C17H27Cl2N |
| Molar Mass | 316.309 |
| Melting Point | 191-192℃ |
| Boling Point | 342.6°C at 760 mmHg |
| Flash Point | 161°C |
| Water Solubility | 2.9 mg/mL |
| Vapor Presure | 7.45E-05mmHg at 25°C |
| Physical and Chemical Properties | Melting Point: 191-192°C solubility: 2.9 mg/mL |
| Use | Used as an antidepressant |
Sibutramine - Nature
Open Data Verified Data
yellowish solid, boiling point 130~155 ℃/130 ~ 170Pa, melting point 51~55 ℃.
Last Update：2024-01-02 23:10:35
Sibutramine - Preparation Method
Open Data Verified Data
p-chlorophenylacetonitrile, KOH and acetonitrile were mixed, and 1,3-= bromopropane was slowly added dropwise at 25 ° C. For reaction. After completion of the reaction, distilled water was added, followed by extraction with hexyl acetate. The extract was washed with water, saturated brine, and dried. The compound was obtained by filtration, concentration under reduced pressure and distillation. Magnesium tablets are dissolved in THF, Dropwise adding isobutyl bromide, then reacting, slowly dropping the THF solution of the compound obtained from the surface, refluxing, and stirring the treated compound with formic acid and formaldehyde solution, the reaction was slowly added to a crushed ice solution of sodium hydroxide with stirring, and then extracted with ether. The extract was washed with saturated brine and water and dried. Filtration and concentration of the filtrate gave sibutramine.
Last Update：2025-06-10 22:55:16
Sibutramine - Application
Open Data Verified Data
developed by Knoll, Inc., Germany, was first launched in the United States in April 1998. As a norepinephrine and 5-HT reuptake inhibitor, sibutramine acts primarily through its metabolites. It can increase physiological satiety, reduce appetite, induce heat production and increase energy consumption by inhibiting the reuptake of monoamine information transmission factors such as 5-HT and norepinephrine, decreased fat accumulation. Obesity Treatment for diet control, exercise failure to reduce and control weight.
Last Update：2025-08-19 16:24:40
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