Sitravatinib
Sitravatinib
CAS: 1123837-84-2
Molecular Formula: C33H29F2N5O4S
Sitravatinib - Names and Identifiers
Sitravatinib - Physico-chemical Properties
| Molecular Formula | C33H29F2N5O4S |
| Molar Mass | 629.6763 |
| Density | 1.417±0.06 g/cm3(Predicted) |
| Boling Point | 833.5±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 32 mg/mL |
| Appearance | Form solid, color Off-white |
| pKa | 13.17±0.70(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Physical and Chemical Properties | Bioactive Sitravatinib (MGCD516, MG-516) is a new type of small molecule inhibitor targeting various RTKs involved in regulating the growth of S180 sarcoma cells, including c-Kit, PDGFRβ, PDGFRα, c-Met and Axl. |
Sitravatinib - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.588 ml | 7.941 ml | 15.881 ml |
| 5 mM | 0.318 ml | 1.588 ml | 3.176 ml |
| 10 mM | 0.159 ml | 0.794 ml | 1.588 ml |
| 5 mM | 0.032 ml | 0.159 ml | 0.318 ml |
Last Update：2024-01-02 23:10:35
Sitravatinib - Uses and synthesis methods
Target
Target Value
DDR2
(Cell-free assay) 0.5 nM
EPHA3
(Cell-free assay) 1 nM
Axl
(Cell-free assay) 1.5 nM
Mer
(Cell-free assay) 2 nM
VEGFR3 (FLT4)
(Cell-free assay) 2 nM
in vitro studies
MGCD516 (Sitravatinib) is an oral small molecule inhibitor that inhibits a group of closely related RTKs, including RET, split RTKs(VEGFR, PDGFR and KIT), TRK family, DDR2 and Axl. MGCD516 result in the phosphorylation of potential drivers RTKs being significantly inhibited and effective antiproliferative effects induced in vitro.
In vivo studies
In non-clinical cancer models containing sitravatinib targets with genetic variants (including RET, NTRK or CHR4q12 amplification), Sitravatinib have anti-tumor activity. In vivo MGCD516 administration of xenograft tumor models can significantly inhibit tumor growth, and its effect is better than that of imatinib and crizotinib (two fully studied multi-kinase inhibitors have overlapping target specificity).
Last Update：2024-04-10 22:41:03
Sitravatinib - Nature
| Solubility | Soluble in DMSO (up to at least 25 mg/ml), or in Ethanol (up to at least 25 mg/ml) |
Last Update：2024-04-09 01:59:50
Supplier List
Featured ProductsSpot supply
Product Name: MG-516 Visit Supplier Webpage Request for quotationCAS: 1123837-84-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Sitravatinib Request for quotationCAS: 1123837-84-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Sitravatinib Visit Supplier Webpage Request for quotationCAS: 1123837-84-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: MGCD516; MG-516 Visit Supplier Webpage Request for quotationCAS: 1123837-84-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Sitravatinib Visit Supplier Webpage Request for quotation
CAS: 1123837-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1123837-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: MG-516 Visit Supplier Webpage Request for quotationCAS: 1123837-84-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Sitravatinib Request for quotationCAS: 1123837-84-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Sitravatinib Visit Supplier Webpage Request for quotationCAS: 1123837-84-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: MGCD516; MG-516 Visit Supplier Webpage Request for quotationCAS: 1123837-84-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Sitravatinib Visit Supplier Webpage Request for quotation
CAS: 1123837-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1123837-84-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History