THIOSTREPTON
THIOSTREPTON
CAS: 1393-48-2
Molecular Formula: C72H85N19O18S5
THIOSTREPTON - Names and Identifiers
THIOSTREPTON - Physico-chemical Properties
| Molecular Formula | C72H85N19O18S5 |
| Molar Mass | 1664.89 |
| Density | 1.0824 (rough estimate) |
| Melting Point | 248-257°C (dec.) |
| Water Solubility | 0.24g/L(28 ºC) |
| Solubility | Soluble in DMSO (10 mg/ml), chloroform (10 mg/ml), dioxane, pyridine, glacial acetic aci |
| Appearance | Off-white powder |
| Color | Off-white |
| Merck | 13,9440 |
| pKa | 10.43±0.46(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week. |
| Refractive Index | 1.6700 (estimate) |
| MDL | MFCD00135828 |
| Physical and Chemical Properties | Bioactive Thiostrepton is an antibiotic that selectively inhibits FOXM1. FOXM1 binds to the YAP/TEAD complex. The binding of YAP/TEAD/FOXM1 complex in the gene regulatory region that controls the cell cycle may affect cell proliferation. |
| Use | A protein synthesis-inhibiting antibiotic |
THIOSTREPTON - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | XN6300100 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29419090 |
| Toxicity | LD50 oral in mouse: > 1gm/kg |
THIOSTREPTON - Uses and synthesis methods
in vitro studies
Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A.
Cell Viability Assay
Cell Line: A2780 and HEC-1A cells
Concentration: 0.01, 0.1, 1, 10, 100, 1000 μM
Incubation Time: 48 hours
Result: The IC 50 s are 1.10 μM in A2780 and 2.22 μM in HEC-1A, respectively.
In vivo studies
Thiostrepton (I .p.; 17 mg/kg) reduces the tumorigenicity of Ewing's sarcoma (EWS) cells. Tumor volumes in control mice have increased ~6-fold from the initiation of treatment, while their Thiostrepton-treated counterparts increase only ~1.7-fold, exhibiting a ~3.5-fold reduction, relative to controls.
Animal Model: Athymic (BALB/c nu/nu) nude mice bearing A4573 cells
Dosage: 17 mg/kg
Administration: Administered I .p.
Result: Treatment inhibited the growth of EWS-derived tumors in vivo.
Last Update：2024-04-09 20:15:17
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