TPI-1
TPI-1
CAS: 79756-69-7
Molecular Formula: C12H6Cl2O2
TPI-1 - Names and Identifiers
TPI-1 - Physico-chemical Properties
| Molecular Formula | C12H6Cl2O2 |
| Molar Mass | 253.08 |
| Solubility | 10 mM in DMSO |
| Storage Condition | 2-8°C |
| In vitro study | SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ + cells and induces IFNγ + cells in human peripheral blood. |
| In vivo study | TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ + cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent. |
TPI-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.951 ml | 19.757 ml | 39.513 ml |
| 5 mM | 0.79 ml | 3.951 ml | 7.903 ml |
| 10 mM | 0.395 ml | 1.976 ml | 3.951 ml |
| 5 mM | 0.079 ml | 0.395 ml | 0.79 ml |
Last Update：2024-01-02 23:10:35
TPI-1 - Reference Information
| biological activity | TPI-1 (Tyrosine Phosphatase Inhibitor 1) is an effective SHP-1 inhibitor, and the IC50 for recombinant SHP-1 is 40 nM. TPI-1 has anti-cancer activity. |
| target | TargetValue SHP-1 (Cell-free say) 40 nM |
| Target | Value |
| SHP-1 (Cell-free assay) | 40 nM |
| in vitro study | SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, PZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ cells and induces IFNγ cells in human peripheral blood. |
| in vivo studies | TPI-1 inhibits the growth of B16 melanoma tumours in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ cells in mice. TPI-1 also inhibits B16 tumour growth and prolongs tumour mice survival as a tolerated s.c. agent. |
Last Update：2024-04-09 20:52:54
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Tel: 609-228-6898
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Mobile: 609-228-6898
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Tel: 18301782025
Email: 3008007409@qq.com
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