TYROSINASE
TYROSINASE
CAS: 9002-10-2
Molecular Formula:
TYROSINASE - Names and Identifiers
| Name | TYROSINASE |
| Synonyms | TYROSINASE exMushroom TyrosinaseExMushroom PHENOLASE FROM POTATO AGARICUSBISPORUSTYROSINASE Polyphenol Oxidase from Mushrooms |
| CAS | 9002-10-2 |
| EINECS | 232-653-4 |
TYROSINASE - Physico-chemical Properties
| Melting Point | 89-94 °C |
| Appearance | lyophilized powder |
| Storage Condition | -20°C |
| MDL | MFCD00082118 |
| Use | Overview tyrosinase has a β-sheet (yellow element of the Secsine part) at the N-terminus and C- terminus, respectively, with several α-helices between the N-terminus and the C- terminus, such a structure facilitates tyrosinase formation of the active center. tyrosinase (tyrosinase,EC 1. 14. 18. 1) widely distributed in microorganisms, animals and plants and the human body, in plants, tyrosinase is generally called polyphenol oxidase; In insects, it is generally called phenol oxidase; In microorganisms and the human body, it is called tyrosinase. Tyrosinase is a key enzyme in the synthesis of melanin and browning of fruits and vegetables. It plays an important role in the tanning process and wound healing of insects. Bacterial melanin can protect bacterial cells and spores from ultraviolet radiation. Tyrosinase has the dual catalytic function of monophenolase and diphenolase. Under the action of monophenolase, tyrosine is hydroxylated into L-dopa (L-DOPA), LDOPA is oxidized to dopa quinone, which undergoes a series of reactions to form melanin. Tyrosinase is abnormal, which may cause melanoma and early-onset Alzheimer's disease. Pigmentation caused by abnormal melanin production is an important manifestation of animal aging and browning of fruits and vegetables. Tyrosinase inhibitors are widely used in many fields, such as beauty and health care, pigment skin disease treatment, pest control and food preservation. |
TYROSINASE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 42 - May cause sensitization by inhalation |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 2 |
| FLUKA BRAND F CODES | 10-21 |
TYROSINASE - Vitality definition
One unit causes an increase in the absorbance at 280nm of 0.001 per minute at 25℃，PH 6.5，using L-tryosine as substrate.
Last Update：2023-08-16 21:32:38
TYROSINASE - Security information
| dangerous goods mark | Xn |
| hazard category code | 42 |
| safety instructions | 22-24/25-45 |
| WGK Germany | 2 |
| F | 10-21 |
Last Update：2024-04-09 20:48:19
TYROSINASE - Introduction
TYROSINASE is an enzyme that catalyzes the metabolism of tyrosine molecules. It is a specific protein found in many organisms, such as bacteria, fungi and mammals.
The main function of TYROSINASE is to catalyze the oxidation of tyrosine and convert tyrosine into tyrosine ketones and amino acids. This enzyme plays a key role in many biological processes, such as regulating tyrosine metabolism and synthesizing important physiologically active substances (such as hormones and neurotransmitters). In addition, TYROSINASE are also widely used in scientific research, pharmaceutical manufacturing and food industry.
The preparation of TYROSINASE usually involves the extraction of purified enzyme from the enzyme source, and through specific separation, purification and detection steps to obtain a high purity TYROSINASE. The specific preparation method may vary according to different enzyme sources and experimental requirements.
Regarding the safety information of TYROSINASE, in general, enzymes are relatively safe under normal use conditions, but the following matters still need to be paid attention:
1. The preparation and use of enzymes should follow the laboratory's safe operating procedures and guidelines.
2. the use of enzyme operators should have the appropriate laboratory skills and knowledge, and strictly abide by the laboratory safety procedures.
3. TYROSINASE may involve harmful or irritating chemicals, such as acids, alkalis and organic solvents, so protective measures should be paid attention.
4. The enzyme should be protected from temperature, humidity and other adverse environmental effects during storage and use to maintain its stability.
5. The amount of enzyme used should be properly controlled and measured according to experimental requirements to avoid excessive use.
6. in the process of enzyme use, pay attention to avoid contact with skin, eyes and mouth, and prevent the inhalation of enzyme solution.
The main function of TYROSINASE is to catalyze the oxidation of tyrosine and convert tyrosine into tyrosine ketones and amino acids. This enzyme plays a key role in many biological processes, such as regulating tyrosine metabolism and synthesizing important physiologically active substances (such as hormones and neurotransmitters). In addition, TYROSINASE are also widely used in scientific research, pharmaceutical manufacturing and food industry.
The preparation of TYROSINASE usually involves the extraction of purified enzyme from the enzyme source, and through specific separation, purification and detection steps to obtain a high purity TYROSINASE. The specific preparation method may vary according to different enzyme sources and experimental requirements.
Regarding the safety information of TYROSINASE, in general, enzymes are relatively safe under normal use conditions, but the following matters still need to be paid attention:
1. The preparation and use of enzymes should follow the laboratory's safe operating procedures and guidelines.
2. the use of enzyme operators should have the appropriate laboratory skills and knowledge, and strictly abide by the laboratory safety procedures.
3. TYROSINASE may involve harmful or irritating chemicals, such as acids, alkalis and organic solvents, so protective measures should be paid attention.
4. The enzyme should be protected from temperature, humidity and other adverse environmental effects during storage and use to maintain its stability.
5. The amount of enzyme used should be properly controlled and measured according to experimental requirements to avoid excessive use.
6. in the process of enzyme use, pay attention to avoid contact with skin, eyes and mouth, and prevent the inhalation of enzyme solution.
Last Update：2024-04-09 21:21:28
TYROSINASE - Nature
| melting point | 89-94 °C |
| storage conditions | -20°C |
| morphology | lyophilized powder |
| EPA chemical information | Oxygenase, monophenol mono- (9002-10-2) |
Last Update：2024-04-09 21:01:54
TYROSINASE - Uses and synthesis methods
How does tyrosinase produce melanin
Tyrosinase (TYR) is a copper-containing enzyme that exists in plant and animal tissues and catalyzes the production of melanin and other pigments from the oxidation of tyrosine, such as exposing peeled or sliced potatoes to blacken in the air. Tyrosinase can be found in the melanosome of skin melanocytes. Human skin turns brown or black when exposed to sunlight is due to the activation of tyrosinase under ultraviolet radiation, which catalyzes the hydroxylation of tyrosine in the body to form dopa, and then oxidizes dopa into dopa. After a series of complex reactions, melanin is finally formed.
Factors affecting tyrosinase activity
1. if patients receive strong light exposure for a long time, a large amount of ultraviolet rays will enter the skin epidermis, inhibit tyrosinase activity, and then lead to melanin loss.
2. If the number of copper ions in patients decreases, it will affect the body's metabolism and the body's endocrine system, thereby affecting tyrosinase activity.
3. The increase of tryptophan and arsenic enzyme activity will inhibit tyrosinase activity, and excessive cysteine, glutathione and tryptophan accumulated in the body due to metabolic disorders will also increase the activity of tryptophan and affect the synthesis of melanin through its reduction effect.
How to increase tyrosinase activity?
The activity of tyrosinase is closely related to copper, iron, zinc and other elements in the human body. Therefore, patients with vitiligo can appropriately eat substances rich in tyrosine and rare elements zinc, copper, and iron to restore tyrosinase activity and help melanocytes produce. For example, animal offal, crustaceans, beans, lentils, green beans, red beans, hard-shelled peanuts, walnuts, black sesame and raisins.
Last Update：2024-04-09 01:59:49
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Featured ProductsMultiple SpecificationsSpot supply
Product Name: Polyphenol oxidase Visit Supplier Webpage Request for quotationCAS: 9002-10-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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Product Name: Tyrosinase Request for quotationCAS: 9002-10-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Tyrosinase Visit Supplier Webpage Request for quotationCAS: 9002-10-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Polyphenol oxidase Visit Supplier Webpage Request for quotationCAS: 9002-10-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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