Tebipenem
Tebipenem
CAS: 161715-21-5
Molecular Formula: C16H21N3O4S2
Tebipenem - Names and Identifiers
Tebipenem - Physico-chemical Properties
| Molecular Formula | C16H21N3O4S2 |
| Molar Mass | 383.49 |
| Density | 1.75 |
| Boling Point | 624.5±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 45 mg/mL; H2O: 6.2 mg/mL |
| pKa | 4.29±0.60(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | Tebipenem exhibits slow tight-binding inhibition at low micromolar concentrations versus the chromogenic substrate nitrocefin, and apparent K m and k cat values of 0.8 μM and 0.03 min -1 , respectively. Tebipenem shows potent activity against B. pseudomallei , with MIC 50 and MIC 90 values of both 2 mg/L. Tebipenem shows good activity against S. pneumoniae , with the MIC range of ≤0.25 μg/mL in all of the S. pneumoniae isolates. |
Tebipenem - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.608 ml | 13.038 ml | 26.077 ml |
| 5 mM | 0.522 ml | 2.608 ml | 5.215 ml |
| 10 mM | 0.261 ml | 1.304 ml | 2.608 ml |
| 5 mM | 0.052 ml | 0.261 ml | 0.522 ml |
Last Update：2024-01-02 23:10:35
Tebipenem - Reference Information
| biological activity | Tebipenem is an oral broad-spectrum carbapenem antibiotic that can inhibit Gram-positive bacteria and Gram-negative bacteria, but has no effect on Pseudomonas aeruginosa. |
| in vitro study | Tebipenem exhibits slow tight-binding inhibition at low micromolar concentrations versus the chromogenic substrate nitrocefin, and apparent K m and k cat values of 0.8 μ m and 0.03 min -1 , respectively. Tebipenem show activity against B. pseudomallei , with MIC 50 and MIC 90 values of both 2 mg/L. Tebipenem shows good activity against S. pneumoniae , with the MIC range of ≤ 0.25 μg/mL in all of the S. pneumoniae isolates. |
Last Update：2024-04-09 20:52:54
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