Tenofovir
tenofovir
CAS: 147127-20-6
Molecular Formula: C9H14N5O4P
Tenofovir - Names and Identifiers
| Name | tenofovir |
| Synonyms | PMPA (R)-PMPA TENOFOVIR tenofovir D,L-TENOFOVIR Tenofovir(ForResearchOnly) (R)-9-(2-Phosphonomethoxypropyl)Adenine (R)-9-(2-PHOSPHONYLMETHOXYPROPYL)-ADENINE (R)-9-[2-(phosphonomethoxy)propyl]adenine (R)-9-[2-(Phosphonomethoxy)propyl]adenine(PMPA) 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid (R)-(1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonic acid [[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid |
| CAS | 147127-20-6 |
| EINECS | 604-571-2 |
| InChI | InChI=1/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m0/s1 |
Tenofovir - Physico-chemical Properties
| Molecular Formula | C9H14N5O4P |
| Molar Mass | 287.21 |
| Density | 1.79±0.1 g/cm3(Predicted) |
| Melting Point | 276-280°C |
| Boling Point | 616.1±65.0 °C(Predicted) |
| Specific Rotation(α) | D +21° (c = 1 in 0.1M HCl) |
| Water Solubility | 13.4 mg/mL (25 ºC) |
| Solubility | H2O: 2 mg/mL |
| Appearance | white to beige powder |
| Color | white to beige |
| Merck | 14,9146 |
| pKa | 2.36±0.10(Predicted) |
| Storage Condition | -20°C |
| MDL | MFCD00943794 |
| Physical and Chemical Properties | Melting point 276-280°C water-soluble 13.4 mg/mL (25°C) |
Tenofovir - Risk and Safety
| RTECS | SZ6563600 |
| HS Code | 29339900 |
Tenofovir - Reference
| Reference Show more | 1. Gong Hongfei, Gao Sheng, Wei Jingchen. Study on the Anti-hepatitis B Virus Effect of Ramie Chlorogenic Acid in Vitro [J]. Journal of Guangxi Academy of Sciences, 2019, 35(01):82-86. 2. Gong Hongfei Pang Fuhua Ruiying et al. Anti-hepatitis B Virus Effect of Three Anti-HBV Nucleoside (Acid) Similar Objects [J]. Experimental Technology and Management 2019 036(009):45-48 56. |
Tenofovir - Nature
Open Data Verified Data
white solid. Melting point 279 °c. Water soluble 13.4mg/mL(25 degrees C). [a]D 210 (c -10.1M HCL). Tenofovir dipentanoyloxymethyl fumarate (Tenofovir diisoproxil Fumar-ate):C19 H30 Ns Oio P.C4 H4 04, white fine crystals.
Last Update：2025-06-10 22:55:16
Tenofovir - Preparation Method
Open Data Verified Data
- diethyl phosphite, paraformaldehyde and triethylamine were dissolved in toluene, reacted under nitrogen, and refluxed. After completion of the reaction, the reaction was cooled, and p-Toluenesulfonyl chloride and triethylamine were slowly added to obtain diethyl p-toluenesulfonyloxymethylphosphonate.
- under the protection of nitrogen, (S)-glycidol, 5% palladium-carbon, ethanol, and an aqueous solution of sodium hydroxide were mixed and subjected to hydrogenation to obtain (ruler)-1.2 propanediol. Add diethyl carbonate and ethanol solution of sodium ethoxide, reaction (R) a 1,2 propylene glycol carbonate. It was dissolved in dimethylformamide with adenine, diethyl p-toluenesulfonyloxymethylphosphonate and sodium hydroxide to give (R)-9-[2-(diethylphosphonomethoxy) propyl] adenine. This was dissolved in acetonitrile, and bromotrimethylsilane was added to obtain a crude product of tenofovir, which was recrystallized to obtain a pure product. The mixture of tenofovir and 1-methyl -2-pyrrolidone and triethylamine was added to the reaction of chloromethyl propyl carbonate, and then acidified with fumaric acid to obtain the trifovir dipivoxil valeryloxymethyl fumarate.
Last Update：2025-06-10 22:55:16
Tenofovir - Application
Open Data Verified Data
nucleotide analogs reverse transcriptase inhibitors, which block HIV replication. In combination with other antiretroviral Virus drugs to treat HIV-1 of infections. For the treatment of AIDS.
Last Update：2025-08-19 16:24:40
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