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Valtrate

Valtrate

CAS: 18296-44-1

Molecular Formula: C22H30O8

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Valtrate - Names and Identifiers

Name Valtrate
Synonyms Valtrate
ValtratuM
18296-44-1
VALTRATE(P)
ValepotriatuM
Valtrate [INN]
Halazuchrome B
HalazuchroMe B
VALTRATE(P)(PLEASE CALL)
(1S,7R)-4-Acetoxymethyl-6,7aα-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1α,6α-diol 1,6-bis(3-methylbutanoate)
(1S,6S,7R,7aS)-4-(Acetoxymethyl)-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)
(1S,6S,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)
(1S,6S,7R,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)
butanoic acid, 3-methyl-, (1S,6S,7R,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1,6-diyl ester
(1S-(1a,6a,7b,7aa))-3-Methylbutanoic Acid 4-((Acetyloxy)methyl)-6,7a-dihydrospiro(cyclopenta[c]pyran-7(1H),2'-oxirane)-1,6-diyl Ester
[(1S,6S,7aS)-4-(Acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
CAS 18296-44-1
EINECS 242-174-2
InChI InChI=1/C22H30O8/c1-12(2)6-18(24)29-17-8-16-15(9-26-14(5)23)10-27-21(20(16)22(17)11-28-22)30-19(25)7-13(3)4/h8,10,12-13,17,20-21H,6-7,9,11H2,1-5H3/t17-,20+,21-,22?/m0/s1

Valtrate - Physico-chemical Properties

Molecular FormulaC22H30O8
Molar Mass422.47
Density1.22±0.1 g/cm3(Predicted)
Boling Point525.9±50.0 °C(Predicted)
Specific Rotation(α)+172.7 (MeOH)
Flash Point226.5°C
Solubility Soluble in methanol, ethanol, DMSO and other organic solvents
Vapor Presure3.75E-11mmHg at 25°C
AppearanceYellow liquid
ColorPale Brown to Dark Yellow to Sticky
Storage ConditionRefrigerator
Refractive Index1.528
MDLMFCD00868024
Physical and Chemical PropertiesYellow liquid, soluble in methanol, ethanol, DMSO and other organic solvents, derived from spider fragrance, valerian.
In vivo study Valepotriateshowed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore,valepotriate(10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore,valepotriate(5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.

Valtrate - Risk and Safety

HS Code29329990

Valtrate - Reference Information

biological activity Valepotriate, isolated from Valeriana jatamansi, has anti-epileptic and anti-cancer activities.
in vivo study Valepotriateshowed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore,valepotriate(10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore,valepotriate(5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.
chemical properties yellow liquid, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from spider fragrance and valerian.
use valerian triester has anti-tumor and anti-senile dementia effects.
used for content determination/identification/pharmacological experiment, etc.
Last Update：2024-04-09 21:04:16
Valtrate
Supplier List
Shanghai Amole Biotechnology Co., Ltd.
Spot supply
Product Name: (1S,6S,7R,7aS)-4-(Acetoxymethyl)-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diylbis(3-methylbutanoate) Request for quotation
CAS: 18296-44-1
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
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MedChemExpress (MCE)
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SKYRUN INDUSTRIAL CO.,LTD
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CAS: 18296-44-1
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Valepotriate Visit Supplier Webpage Request for quotation
CAS: 18296-44-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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Shanghai Amole Biotechnology Co., Ltd.
Spot supply
Product Name: (1S,6S,7R,7aS)-4-(Acetoxymethyl)-6,7a-dihydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diylbis(3-methylbutanoate) Request for quotation
CAS: 18296-44-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Valepotriate Visit Supplier Webpage Request for quotation
CAS: 18296-44-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: Valepotriate Visit Supplier Webpage Request for quotation
CAS: 18296-44-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: Valepotriate Visit Supplier Webpage Request for quotation
CAS: 18296-44-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Valepotriate Visit Supplier Webpage Request for quotation
CAS: 18296-44-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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Valtrate
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