Vancomycin
Vancomycin
CAS: 1404-90-6
Molecular Formula: C66H75Cl2N9O24
Vancomycin - Names and Identifiers
| Name | Vancomycin |
| Synonyms | Vancoled HSDB 3262 Vancomycin VANCOMYCIN UNII-6Q205EH1VU Vancomycin Base Vancomycinum [INN-Latin] vancomycin hcl vancocin Vancomycine [INN-French] Vancomicina [INN-Spanish] |
| CAS | 1404-90-6 |
| EINECS | 215-772-6 |
| InChI | InChI=1/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1 |
Vancomycin - Physico-chemical Properties
| Molecular Formula | C66H75Cl2N9O24 |
| Molar Mass | 1449.25 |
| Density | 1.2882 (rough estimate) |
| Melting Point | >274°C (dec.) |
| Solubility | DMSO (Slightly) |
| Appearance | Solid |
| Color | Off-White |
| pKa | pKa 2.18±0.08(H2Ot = 25.0±0.1I = 0.2 (NaCl)N2 atmosphere) (Uncertain);7.75±0.02(H2Ot = 25.0±0.1I = 0 |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.7350 (estimate) |
| In vitro study | Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci . |
| In vivo study | Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment. |
Vancomycin - Reference
| Reference Show more | 1. Cui Ruoyu, Li Meina, Fang Ting, et al. Study on Rapid Chiral Separation of Alanine by Paper Chromatography [J]. Chemistry Education, 2018, 039(004):22-24. 2. Pan Wenjuan, Lin Jiafu, Wang Xiaotao, Guo Yidong, Chu Yiwen, Liu Chaolan. Isolation, Identification and Antibacterial Activity Determination of Actinomycetes from Tibetan Lakes [J]. Biotechnology Bulletin, 2020,36(07):97-103. 3. Zhang, Fangxing, et al. "The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice." Frontiers in microbiology 11 (2020): 2126.https://doi.org/10.3389/fmicb.2020.557342 4. [IF = 9.229] Mimi Wan et al. "In Situ Growth of Mesoporous Silica with Drugs on Titanium Surface and Its Biomedical Applications." Acpplmater Inter. 2017;9(22):18609-18618 5. [IF = 3.659] Rong Qian et al. "in vitro and in vivo bactericidal activity of Tinospora sagittata (Oliv.) Gagnep. var. craveniana (S.Y.Hu) Lo and its main effective component, palmatine, against porcine Helicobacter pylori." Bmc Complem Altern M. 2016 Dec;16(1):1-8 6. [IF = 10.588] Fangchao Yin et al. "A portable digital optical kanamycin sensor developed by surface-anchored liquid crystal droplets." J Hazard Mater. 2021 Oct;420:126601 7. [IF = 7.514] Ximo Wang et al. "A novel SERS sensor for the ultrasensitive detection of kanamycin based on a Zn-doped carbon quantum dot catalytic switch controlled by nucleic acid aptamer and size-controlled gold nanorods." Food Chem. 2021 Nov;362:130261 8. [IF = 7.328] Tianjie Chen et al. "Construction and performance evaluation of a sustained release implant material polyetheretherketone with antibacterial properties." Mat Sci Eng C- Mater. 2021 Jul;126:112109 9. [IF = 4.235] Zhang Fangxing et al. "The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice." Front Microbiol. 2020 Oct;0:2126 10. [IF = 2.461] Huang Xue-Jiao et al. "The Antibacterial Properties of 4, 8, 4 ′, 8 '-Tetramethoxy (1,1'-biphenanthrene) -2,7,2 ', 7'-Tetrol from Fibrous Roots of Bletilla striata." Indian J Microbiol. 2021 Jun;61(2):195-202 11. [IF = 2.281] Zhiqiang Zhang et al. "Contribution of the colicin receptor CirA to biofilm formation, antibotic resistance, and pathogenicity of Salmonella Enteritidis." J Basic Microb. 2020 Jan;60(1):72-81 12. [IF = 6.057] Supan Cheng et al. "Liquid crystal-based sensitive and selective detection of URIC ACID and uricase in body fluids." Talanta 2022 Jul;244:123455 |
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