Verapamil
verapamil
CAS: 52-53-9
Molecular Formula: C27H38N2O4
Verapamil - Names and Identifiers
| Name | verapamil |
| Synonyms | verapamil Verapamil 2-isopropyl- NSC 272306NA dl-Verapamil -2-isopropyl- 4-dimethoxy-alpha-(1-methylethyl)-l)- 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylv 2-[3,4-di(methoxy)phenyl]-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-isopropyl-pentanenitrile alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)- (9CI) Benzeneacetonitrile, .alpha.-3-2-(3,4-dimethoxyphenyl)ethylmethylaminopropyl-3,4-dimethoxy-.alpha.-(1-methylethyl)- |
| CAS | 52-53-9 |
| EINECS | 200-145-1 |
| InChI | InChI=1/C27H37N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,7-8,13-16H2,1-6H3 |
Verapamil - Physico-chemical Properties
| Molecular Formula | C27H38N2O4 |
| Molar Mass | 454.61 |
| Density | 1.1267 (rough estimate) |
| Melting Point | 25°C |
| Boling Point | 243-246 °C (1.3 Pa) |
| pKa | 8.6(at 25℃) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.5448 |
| Physical and Chemical Properties | A viscous, yellowish oily liquid. Boiling point 243-246 ℃(1.3Pa), refractive index (nD25)1.5448. Soluble in benzene and ether, easily soluble in lower alcohols, acetone, ethyl acetate, chloroform, hardly soluble in hexane, insoluble in water. Its hydrochloride ([152-11-4]) is white to white crystalline powder. Melting point 138.5-140.5 ℃ (decomposition). Soluble in methanol, dimethylformamide, soluble in ethanol, isopropanol, acetone, ethyl acetate, insoluble in chloroform. No smell, bitter taste. |
Verapamil - Risk and Safety
| Toxicity | LD50 oral in rat: 163mg/kg |
Verapamil - Reference
| Reference Show more | 1. Tao Li, Xiaoliang Zhao, NEI, Ying-Lan et al. Study on brain permeability of sinomenine and tetramethylpyrazine in CQ analgesic compound [J]. Journal of Pharmacy 2019 v.54(12):186-193. 2. Lu Jialu, Deng Lina. Preparation of curcumin-tryptophan coamorphous and its pharmacokinetics in rats [J]. China Pharmacy, 2019, 25 (17):2348-2354. 3. Wang, Jinli, et al. "In vitro synergistic effect of baicalin." Poltry science 98.1 (2019): 373-380.https:// doi.org/10.3382/ps/pey356 4. Wang, Xin, et al. "Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats." Journal of ethnopharmacology 209 (2017): 175-183.https://doi.org/1 5. [IF=4.384] Rong Huang et al."Surfactant-free solid dispersion of BCS class IV drug in an amorphous chitosan oligosaccharide matrix for concomitant dissolution in vitro - permeability increase."Eur J Pharm Sci. 2019 Mar;130:147 6. [IF=4.36] Xin Wang et al."Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats."J Ethnopharmacol. 2017 Sep;209:175 7. [IF=3.667] Huang Yuanjia et al."Molecular cloning and characterization of calmodulin-like protein CaLP from the Scleractinian coral Galaxea astreata."Cell Stress Chaperon. 2018 Nov;23(6):1329-1335 8. [IF=1.627] Yanming Xia et al."Transport mechanism of ursodeoxycholic acid in human placental BeWo cells."Biopharm Drug Dispos. 2018 Jul;39(7):335-343 9. [IF=4.384] Juanhong Zhang et al."Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats."Eur J Pharm Sci. 2020 Oct;153:105490 10. [IF=3.352] Jinli Wang et al."In vitro synergistic effect of baicalin with azithromycin against Staphylococcus saprophyticus isolated from francolins with ophthalmia."Poultry Sci. 2019 Jan;98:373 11. [IF=3.981] Xiao-Hang Liu et al."Comparison of the permeability between conjugated estrogens and atenolol in rat in situ single-pass intestinal perfusions model and in Caco-2 cell monolayers."J Drug Deliv Sci Tec. 2022 Feb;68:102786 |
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