Verubecestat
Verubecestat
CAS: 1286770-55-5
Molecular Formula: C17H17F2N5O3S
Verubecestat - Names and Identifiers
Verubecestat - Physico-chemical Properties
| Molecular Formula | C17H17F2N5O3S |
| Molar Mass | 409.41 |
| Density | 1.52±0.1 g/cm3(Predicted) |
| Melting Point | 160-162oC |
| Solubility | DMSO: ≥ 35 mg/mL |
| Appearance | Solid |
| Color | White |
| pKa | 9.92±0.70(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| In vitro study | Verubecestat(MK-8931) effectively reduced Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM. |
| In vivo study | A single oral dose of Verubecestat(MK-8931) in rats and cynomolgus monkeys significantly reduced cerebral spinal fluid (CSF) and cortical aβ40. MK-8931 in vivo half-life of 20 hours, suitable for once daily dosing frequency. |
Verubecestat - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.443 ml | 12.213 ml | 24.425 ml |
| 5 mM | 0.489 ml | 2.443 ml | 4.885 ml |
| 10 mM | 0.244 ml | 1.221 ml | 2.443 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.489 ml |
Last Update：2024-01-02 23:10:35
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