boc-L-valine
N-(tert-Butoxy carbonyl)-L-valine
CAS: 13734-41-3
Molecular Formula: C10H19NO4
boc-L-valine - Names and Identifiers
| Name | N-(tert-Butoxy carbonyl)-L-valine |
| Synonyms | BOC-VALINE Boc-Val-OH Boc-l-Val-OH Boc-L-Valine BOC-VALINE-OH N-Boc-L-Valine Bok - L - valine N-(tert-butoxycarbonyl)valine N-(tert-butoxycarbonyl)-D-valine N-(tert-Butoxycarbonyl)-L-valine N-(tert-butoxycarbonyl)-L-valine N-(tert-Butoxy carbonyl)-L-valine (S)-2-(Boc-Amino)-3-Methylbutyric Acid Valine, N-carboxy-, N-tert-butyl ester, L- (8CI) (2S)-2-[(tert-butoxycarbonyl)amino]-3-methylbutanoate (2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoic acid (2S)-2-[(tert-butoxy-oxomethyl)amino]-3-methylbutanoic acid (2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid |
| CAS | 13734-41-3 |
| EINECS | 237-307-6 |
| InChI | InChI=1/C10H19NO4/c1-6(2)7(8(12)13)11-9(14)15-10(3,4)5/h6-7H,1-5H3,(H,11,14)(H,12,13)/p-1/t7-/m0/s1 |
| InChIKey | SZXBQTSZISFIAO-ZETCQYMHSA-N |
boc-L-valine - Physico-chemical Properties
| Molecular Formula | C10H19NO4 |
| Molar Mass | 217.26 |
| Density | 1.1518 (rough estimate) |
| Melting Point | 77-80°C(lit.) |
| Boling Point | 357.82°C (rough estimate) |
| Specific Rotation(α) | -6.3 º (c=1,CH3COOH) |
| Flash Point | 160.5°C |
| Water Solubility | insoluble |
| Solubility | Insoluble in water |
| Vapor Presure | 0.002Pa at 25℃ |
| Appearance | White crystal |
| Color | White |
| BRN | 1711290 |
| pKa | 4.01±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | -6.5 ° (C=1, AcOH) |
| MDL | MFCD00065605 |
| Physical and Chemical Properties | Melting point 77-80°C(lit.) specific optical rotation -6.3 ° (c = 1,CH3COOH) refractive index -6.5 ° (C = 1, AcOH) storage conditions -20°C water-soluble insoluble BRN 1711290 |
| Use | For polypeptide synthesis, as amino acid protection monomer. Intermediate of luteolin |
boc-L-valine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 2924 19 00 |
| Hazard Class | IRRITANT |
boc-L-valine - Reference Information
| LogP | 1.752 at 25℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Introduction | (S)-2-(tert-butoxycarbonyl-amino)-3-methylbutyric acid, also known as N-BOC-L-valine, is a pharmaceutical intermediate. |
| Application | (S)-2-(tert-butoxycarbonyl-amino)-3-methylbutyric acid can be used for valaciclovir, Ganciclovir, valaciclovir and other Lovir series side chain synthesis, pressurizer and other peptides synthesis. |
| Use | Used for polypeptide synthesis and as an amino acid protective monomer. Valgencilovir intermediate used in biochemical reagents, Valgencilovir or valaciclovir and other Lovir series side chain synthesis, peptide synthesis. |
| production method | using tert-butoxycarbonyl azide and L-valine as raw materials, the crude product is prepared by acylation under alkaline conditions, and then extracted by ether and ethyl acetate, recrystallized and refined to obtain the product. |
Last Update：2024-04-09 19:05:10
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