dichlorphenamide
dichlorphenamide
CAS: 120-97-8
Molecular Formula: C6H6Cl2N2O4S2
dichlorphenamide - Names and Identifiers
dichlorphenamide - Physico-chemical Properties
| Molecular Formula | C6H6Cl2N2O4S2 |
| Molar Mass | 305.16 |
| Density | 1.7263 (rough estimate) |
| Melting Point | 239-241° (patent, mp 228.5-229°) |
| Boling Point | 590.5±60.0 °C(Predicted) |
| Flash Point | 115.9°C |
| Solubility | Acetonitrile (Slightly), Chloroform, DMSO (Slightly), Methanol |
| Vapor Presure | 0.0079mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | pKa 7.4 (Uncertain);8.6 (Uncertain) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.6000 (estimate) |
| Physical and Chemical Properties | White or nearly white crystalline powder. Melting point 239-241 °c. Soluble in ethanol, soluble in alkaline solution, almost insoluble in water or chloroform. No odor, slightly bitter taste. |
| Use | Used as an intermediate |
dichlorphenamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 63 - Possible risk of harm to the unborn child |
| Safety Description | 36 - Wear suitable protective clothing. |
| RTECS | CZ9200000 |
| HS Code | 2935904000 |
dichlorphenamide - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Almost odorless.
- This product is soluble in ethanol, almost insoluble in water or three gas methane; Soluble in alkaline solution.
melting point
The melting point of this product (General 0612) is 238~242.
Last Update：2022-01-01 11:33:35
dichlorphenamide - Standard
Authoritative Data Verified Data
This product is 4,5-two gas isophthalamide. Calculated as dry product, containing no less than 98.0% of C6H6C12N204S2.
Last Update：2024-01-02 23:10:35
dichlorphenamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.277 ml | 16.385 ml | 32.77 ml |
| 5 mM | 0.655 ml | 3.277 ml | 6.554 ml |
| 10 mM | 0.328 ml | 1.638 ml | 3.277 ml |
| 5 mM | 0.066 ml | 0.328 ml | 0.655 ml |
Last Update：2024-01-02 23:10:35
dichlorphenamide - Differential diagnosis
Authoritative Data Verified Data
- take a small amount of this product, add an appropriate amount of sodium carbonate or sodium hydroxide, and melt with small fire. The generated gas can make the wet red litmus test paper turn blue, the residue should be identified by the reaction of the product with the sulfate (General 0301).
- take this product, add 0.4% sodium hydroxide solution to make a solution containing 0401 mg per 1 ml, according to UV-visible spectrophotometry (general rule) determination, there is a maximum absorption at wavelengths of 284nm and 294nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 54).
Last Update：2022-01-01 11:33:36
dichlorphenamide - Exam
Authoritative Data Verified Data
clarity of alkaline solution
take l.Og of this product, add 10ml of sodium hydroxide solution to dissolve, the solution should be clarified.
chloride
take 0.25g of this product, add 25ml of water, shake for 5 minutes, filter, take the filtrate to check according to law (General rule 0801), and compare with the control solution made of 7.0ml of standard sodium chloride solution, no more concentrated (0.028%).
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing 2mg per 1 ml as a test solution; Take appropriate amount of precision, A solution containing 40ug per 1 ml was prepared as a control solution by quantitative dilution with mobile phase. According to the test of high performance liquid chromatography (General rule 0512), silica gel bonded with decylsilane was used as the filler; Phosphate buffer solution was used (5.52 of water was added to dissolve the anhydrous disodium hydrogen phosphate 5.68g and sodium dihydrogen phosphate g).-Acetonitrile (1:1) as mobile phase; Detection wavelength was 280nm. The control solution 10 u1 was taken and injected into the human liquid chromatograph, and the flow rate was adjusted so that the retention time of the main peak was about 7 minutes. Then the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 2 times of the retention time of the main component peak.
Impurity peak, and the sum of each impurity peak area shall not be greater than the main peak area of the control solution (2.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Heavy metals
take this product L. 0g, inspection according to law (General Principles 0821 third law), containing heavy metals shall not exceed 10 parts per million.
Last Update：2022-01-01 11:33:37
dichlorphenamide - Content determination
Authoritative Data Verified Data
take this product about 0.3g, precision weighing, according to the nitrogen determination method (General 0704 first method) determination. Each 1 ml of sulfuric acid titration solution (0.05mol/L) corresponds to 15.26mg of C6H6C12N204S2.
Last Update：2022-01-01 11:33:37
dichlorphenamide - Category
Authoritative Data Verified Data
carbonic anhydrase inhibitor.
Last Update：2022-01-01 11:33:37
dichlorphenamide - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:33:37
dichlorphenamide - Diclofenac hydrochloride tablets
Authoritative Data Verified Data
This product contains two gas phenalamine (C6H6Cl2N204S2) should be 93.0% to 107.0% of the label amount.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (equivalent to about 0.2g of digasenamine), and show the same reaction according to item (1) of identification under digasenamine.
- the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at wavelengths of NM and Nm.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
Take 10 tablets of this product, precision weighing, fine, precision weighing an appropriate amount (about 50mg equivalent to dichlorofinalamine), put it in a 100ml measuring flask, add 50ml of 0.4% sodium hydroxide solution, fully shake to dissolve the diamine, dilute to the scale with 0.4% sodium hydroxide solution, shake well, filter, and take a precise amount. Dilute the filtrate to a standard with 0.4% sodium hydroxide solution. Shake the filtrate to a standard, then use UV-Vis spectrophotometry (General rule 0401), the absorbance was measured at a wavelength of 284mn and calculated as the absorption coefficient of C6H6Cl2N204S2 was 43.4.
category
Same as dichlorofinamine.
specification
25mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:33:38
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