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escin

Aescine

CAS: 6805-41-0

Molecular Formula: C55H86O24

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escin - Names and Identifiers

Name Aescine
Synonyms ESCIN
Escin
Aescin
a-4700
AESCIN
Aescine
aescusan
BETA-AESCIN
amorphousaescin
Chestnuts extract
Horse chestnut extract
Extract of horse chestnut
(2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8R,8aS,9S,10S,12aR,14aR,14bS)-9-Acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid
(2S,3S,4S,5R,6R)-6-[[(4S,6aR,6bS,8R,8aR,9R,10R,14bR)-9-acetoxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy]tetrahydropyran-2-carboxylic acid
CAS 6805-41-0
EINECS 229-880-6
InChI InChI=1/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10-/t26?,27-,28-,29?,30?,31-,32+,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43-,44+,47+,48+,49-,51+,52-,53-,54-,55+/m1/s1

escin - Physico-chemical Properties

Molecular FormulaC55H86O24
Molar Mass1131.26
Density1.1200 (rough estimate)
Melting Point224.5°C
Boling Point764.81°C (rough estimate)
Flash Point311.8°C
Solubility Soluble in methanol.
Vapor Presure0mmHg at 25°C
AppearanceWhite powder
Colorwhite
Merck13,3730
Storage Condition2-8℃
SensitiveEasily absorbing moisture
Refractive Index1.6500 (estimate)
MDLMFCD00076054
In vitro studyEscin can effectively inhibit the proliferation of pancreatic cancer cells, but it has little effect on normal skeletal muscle cells. Escin enhances the proliferation-inhibiting and apoptosis-inducing effects of gemcitabine in BxPC-3 and PANC-1 cells. Escin also downregulates the activation of gemcitabine-induced NF-kB and its downstream gene products in pancreatic cancer cells.
In vivo studyEscin enhances the therapeutic effect of gemcitabine in nude mice bearing BxPC-3 xenografts. Ecin and gemcitabine have a significant synergistic effect on inhibiting the growth of pancreatic tumors, inhibiting proliferation and inducing apoptosis of tumor cells. Escin enhances the inhibitory effect of gemcitabine on NF-kB and NF-kB regulated gene products.

escin - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk CodesR22 - Harmful if swallowed
R20/22 - Harmful by inhalation and if swallowed.
Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
UN IDsUN 3077 9 / PGIII
WGK Germany2
RTECSKF6296000

escin - Reference

Reference
Show more
1. Wang Mingmei, Wang Chenyang, Zhang Min, et al. Study on production of Escin by cell culture of Aesculus chinensis embryo [J]. Chinese herbal medicine 2017 040(007):1552-1557.
2. Wang Mingmei, Wang Chenyang, Zhang Min, et al. Callus culture and Escin content analysis of Aesculus chinensis embryo [J]. Journal of Biology, 2017, 34(004):53-57.
3. [IF = 4.36] Liudai Zhang et al."Amiliorative effects of escin on neuropathic pain induced by chronic constriction injury of sciatic nerve."J Ethnopharmacol. 2021 Mar;267:113503
4. [IF=1.959] Changjun Chen et al."Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells."Febs Open Bio. 2019 May;9(5):891-900

escin - Reference Information

efficacy The extracts from horse chestnut and horse chestnut, which promote the synthesis of pectin and repair damaged skin, can effectively moisturizing rich flavonoids, with natural strong anti-aging anti-wrinkle effect, can improve some eye skin blood circulation, and can also eliminate cellulite, dark circles and eye bags have some effect.
trait brownish yellow to white crystalline powder; Slightly gas, bitter.
Use Escin has the advantages of anti-tissue edema, reducing vascular permeability and preventing water accumulation in tissues, rapid elimination of the feeling of heaviness and pressure caused by local edema. It can be used to treat stomach cold pain, abdominal distention, Veratrum pain, malaria, dysentery.
biological activity Escin (Aescin) is a mixture of saponins found in Aesculus chinensis Bunge, vascular protection.
Last Update：2024-04-09 21:01:54
escin
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: Escin Visit Supplier Webpage Request for quotation
CAS: 6805-41-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Amole Biotechnology Co., Ltd.
Spot supply
Product Name: Aescine Request for quotation
CAS: 6805-41-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Escin Visit Supplier Webpage Request for quotation
CAS: 6805-41-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Changsha Staherb Natural Ingredients Co., Ltd.,
Spot supply
Product Name: Horse chestnut extract Escin Visit Supplier Webpage Request for quotation
CAS: 6805-41-0
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783 18374838656
QQ: 484702402 Click to send a QQ message
Wechat: +86 13875855783
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
MedChemExpress (MCE)
Spot supply
Product Name: Escin Visit Supplier Webpage Request for quotation
CAS: 6805-41-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
BOC Sciences
Spot supply
Product Name: Escin Visit Supplier Webpage Request for quotation
CAS: 6805-41-0
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: Escin Visit Supplier Webpage Request for quotation
CAS: 6805-41-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Escin Visit Supplier Webpage Request for quotation
CAS: 6805-41-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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