ethionamide
ethionamide
CAS: 536-33-4
Molecular Formula: C8H10N2S
ethionamide - Names and Identifiers
| Name | ethionamide |
| Synonyms | 1314th 1314 TN 1314 TH Ethinamide ethionamide 2-ethylisonicotinethioamide 2-Ethyl-4-thioamidylpyridine 2-Ethylisonicotinic thioamide 2-Ethyl-4-thiocarbamoylpyridine 2-ethylisonicotinicacidthioamide 2-ethylpyridine-4-carbothioamide 2-Ethylisonicotinic acid thioamide 2-(ethylsulfanyl)pyridine-4-carboxamide |
| CAS | 536-33-4 |
| EINECS | 208-628-9 |
| InChI | InChI=1/C8H10N2OS/c1-2-12-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11) |
| InChIKey | AEOCXXJPGCBFJA-UHFFFAOYSA-N |
ethionamide - Physico-chemical Properties
| Molecular Formula | C8H10N2S |
| Molar Mass | 166.24 |
| Density | 1.1332 (rough estimate) |
| Melting Point | 164 °C |
| Boling Point | 167 °C / 1mmHg |
| Flash Point | >110°(230°F) |
| Water Solubility | Soluble in DMSO. Sparingly soluble in water |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Yellow crystal |
| Color | Yellow |
| Merck | 14,3737 |
| pKa | pKa 4.37(H2O t=25.0 I=0.025) (Uncertain) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5500 (estimate) |
| MDL | MFCD00057361 |
| Use | With inhibition of tuberculosis, high concentration of bactericidal effect |
ethionamide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R63 - Possible risk of harm to the unborn child |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| RTECS | NS0350000 |
| HS Code | 29333990 |
| Toxicity | LD50 oral in rat: 1320mg/kg |
ethionamide - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 3 (Vol. 13, Sup 7) 1987 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | Ethyl isotinium is combined with other anti-tuberculosis drugs for first-line drugs (such as streptomycin, isoniazid, rifampicin and ethambutol) Invalid tuberculosis patients (retreatment), including tuberculous meningitis. This product can be combined with other anti-leprosy drugs for the treatment of leprosy. It can also be used for the treatment of non-tuberculous mycobacterial infections such as bird compound mycobacterial disease. It has the effect of inhibiting tuberculosis bacteria and sterilizing at high concentration. It has the bactericidal effect of inhibiting tuberculosis bacteria and high concentration |
| usage and dosage | the dosage of the drug varies from person to person, please follow the doctor's advice or the drug instructions. The following are common doses. If your dosage is different, please do not change the dosage without the permission of your doctor. adult oral administration: combined with other anti-tuberculosis drugs, 500~600mg a day, divided into 2~3 times immediately after meals. children oral administration: combined with other anti-tuberculosis drugs, at a time according to the weight of 4 mg/kg, once every 8 hours. |
| precautions | 1. after taking the medicine, there are nausea, vomiting, abdominal pain, diarrhea, anorexia, stomach discomfort and other symptoms, which occur more than 2-3 weeks after taking the medicine. if you cannot tolerate it, you can reduce the dose or suspend the medicine, and continue taking the medicine after the symptoms disappear. If combined with sodium bicarbonate or enteric-coated tablets, the reaction can be reduced. When vomiting occurs, antiemetic drugs can be used at the same time. 2. A few patients have pellagra symptoms, mental depression, vision disorders and headache, peripheral neuritis, menstrual disorders, feminization of male breasts, alopecia, joint pain, rash, acne, etc. 3.20% ~ 30% patients can affect liver function, cause elevated aminotransferase and jaundice, so liver function should be tested once a month. 4. Pregnant women and children under 12 years old are prohibited. 5. High dose can cause orthostatic hypotension. |
| adverse reactions | can cause gastrointestinal reactions: nausea, vomiting, loss of appetite, abdominal distension and diarrhea. Individual cases include depression, visual impairment, headache, peripheral neuritis, joint pain, rash, and acne. It can cause liver damage, elevated transaminase, yellow gallbladder, and liver function should be checked regularly. Individual cases can cause diabetes and acute rheumatic pain. Women may have menstrual disorders and male breast enlargement. High doses may have orthostatic hypotension. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:09
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