sinomenine
sinomenine
CAS: 115-53-7
Molecular Formula: C19H23NO4
sinomenine - Names and Identifiers
sinomenine - Physico-chemical Properties
| Molecular Formula | C19H23NO4 |
| Molar Mass | 329.39 |
| Density | 1.2012 (rough estimate) |
| Melting Point | 180°C (dec.)(lit.) |
| Boling Point | 466.98°C (rough estimate) |
| Specific Rotation(α) | D26 -71° (c = 2.1 in alc) |
| Flash Point | 264.442°C |
| Solubility | Soluble in ethanol, acetone, chloroform and dilute alkali, hot benzene, slightly soluble in water, ether and benzene. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Needle crystal |
| Merck | 13,8620 |
| pKa | 9.72±0.40(Predicted) |
| Storage Condition | Store at +4°C |
| Refractive Index | 1.5000 (estimate) |
| MDL | MFCD00134303 |
| Physical and Chemical Properties | Soluble in ethanol, acetone, chloroform and dilute alkali, hot benzene, water-soluble, ether and benzene. It is derived from the leaves of the plant of the control family. |
sinomenine - Risk and Safety
| Risk Codes | R45 - May cause cancer R46 - May cause heritable genetic damage R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R48/20/22 - R40 - Limited evidence of a carcinogenic effect R22 - Harmful if swallowed R63 - Possible risk of harm to the unborn child |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | QD2170000 |
| FLUKA BRAND F CODES | 9 |
| HS Code | 29399990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in mice: 580 mg/kg (Fu) |
sinomenine - Reference
| Reference Show more | 1. He Wanwan, Zhang Jiankui, Li Yun, Jing Kang Tingguo. Correlation between Microscopic Characteristic Index and Chemical Composition of North Bean Root [J]. Chinese Journal of Experimental Presentation 2017 23(01):42-46. 2. He Wanwan, Zhang Jiankui, Li Yun, Jing Kang Tingguo. Correlation between Powder Color and Effective Components of Rhizoma nigrouensis [J]. Chinese Journal of Experimental Prescritique 2017 23(05):57-62. 3. Wang Wei, Wei Xiaohui. Evaluation of Transdermal Release Performance of Norisopolidine Hydrochloride Cream by Skin Microdialysis in Vivo [J]. Shanghai Journal of Traditional Chinese Medicine, 2019(9). 4. Jiang Longbo, Zhang Yiren, Zhang Keren, such as. Orthogonal design test method to optimize the water extraction process parameters of Guxi Kangfu Pill [J]. China Medical Guide, 2017(4). 5. Tang Lina, Li Yutao, Liang Fengxia, et al. Development of acupuncture sensor needle and its application in the detection of nitric oxide release from cells regulated by active ingredients of traditional Chinese medicine [J]. Chinese Journal of Traditional Chinese Medicine, 2019, v.34(08):93-97. 6. Li Jia, Fu Tingting, Zhang Guangfeng, Liu Xiangqian, Chen Min. Sinomenine induces apoptosis of human rheumatoid arthritis fibroblast-like synovial cells through miR-23b-3p/FGF9 [J]. Chinese Journal of Pathophysiology, 2020,36(09):1653-1660. 7. Hu Shishang, Zhou Yuanyuan, Wu Zihao, Zhu Min, Xi Xueyan, Du Boyu, Yu Qingqing. Effect of Paris saponin Ⅶ on pancreatic cancer cells [J]. Journal of Hubei Medical College, 2020,39(06):544-550 528 8. Sun, Shuangjiao, et al. "Simultaneous Electrochemiluminescence Determination of Sinomenine, cepharanthine and Tetrahydropalmatine in Stephania epigaea by Capillary Electrophoresis Coupled with Ultrasonic-Assisted Aqueous Two-Phase Extraction." Int. J. Elec 9. [IF = 4.411] Jinjun Shan et al. "Liquid Chromatography Coupled with Linear Ion Trap Hybrid OrbitrapMass Spectrometry for Determination of Alkaloids in Sinomeniumacutum." Molecules. 2018 Jul;23(7):1634 10. [IF = 4.759] Rong Wang et al. "Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution say to accelerate alkaloid drug discovery." J Ch 11. [IF = 3] Qu Lala et al. "Phenotypic assessment and screening of ETA/ETB receptors with label-free dynamic mass redistribution say." N-S Arch Pharmacol. 2020 Jun;393(6):937-950 |
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