tak733
tak733
CAS: 1035555-63-5
Molecular Formula: C17H15F2IN4O4
tak733 - Names and Identifiers
tak733 - Physico-chemical Properties
| Molecular Formula | C17H15F2IN4O4 |
| Molar Mass | 504.23 |
| Density | 1.91±0.1 g/cm3(Predicted) |
| Boling Point | 530.5±60.0 °C(Predicted) |
| pKa | 13.72±0.20(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | TAK-733 is a highly potent and selective allosteric site inhibitor of MEK with an IC50 of 3.2 nM. TAK-733 exhibited potent enzymatic and cellular activity with an EC50 of 1.9 nM for ERK phosphorylation in cells. |
| In vivo study | TAK-733 demonstrated broad-spectrum antitumor activity in mouse xenograft models of human tumors, including melanoma, colorectal, NSCLC, pancreatic, and breast cancers. TAK-733 has good pharmacokinetic and pharmacodynamic tolerability and can be administered orally once daily to humans. The maximum effective dose of TAK-733 is 10 mg/kg once daily. |
tak733 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.983 ml | 9.916 ml | 19.832 ml |
| 5 mM | 0.397 ml | 1.983 ml | 3.966 ml |
| 10 mM | 0.198 ml | 0.992 ml | 1.983 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.397 ml |
Last Update：2024-01-02 23:10:35
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CAS: 1035555-63-5
Tel: 18301782025
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Multiple SpecificationsSpot supply
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Tel: 400-968-2212
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Spot supply
Product Name: TAK-733 Visit Supplier Webpage Request for quotationCAS: 1035555-63-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: TAK-733 Visit Supplier Webpage Request for quotation
CAS: 1035555-63-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1035555-63-5
Tel: 18301782025
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View History
tak733
镁 制备
trans-permethrin acid
SAGE
GENTIAN VIOLET 10B
Ferrous
4-TRITYLPHENOL
Nudifloric Acid
(3-CARBOXYPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE
Crocetane
镁 制备
trans-permethrin acid
SAGE
GENTIAN VIOLET 10B
Ferrous
4-TRITYLPHENOL
Nudifloric Acid
(3-CARBOXYPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE
Crocetane