tectorigenin
tectorigenin
CAS: 548-77-6
Molecular Formula: C16H12O6
tectorigenin - Names and Identifiers
| Name | tectorigenin |
| Synonyms | Tectrigenin Tectorigenin tectorigenin Tectorigenine 4',5,7-Trihydroxy-6-methoxyisoflavone 5,7-Dihydroxy-3-(4-hydroxy-phenyl)-6-methoxy-chromen-4-one 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one 6-Methoxy-5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one 4H-1-benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-6-methoxy- Tectorigenin 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one |
| CAS | 548-77-6 |
| InChI | InChI=1/C16H12O6/c1-21-16-11(18)6-12-13(15(16)20)14(19)10(7-22-12)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3 |
tectorigenin - Physico-chemical Properties
| Molecular Formula | C16H12O6 |
| Molar Mass | 300.26 |
| Density | 1.512 |
| Melting Point | 225-226° |
| Boling Point | 361.5°C (rough estimate) |
| Solubility | DMSO : 150 mg/mL (499.57 mM; Need ultrasonic and warming) |
| Appearance | Light yellow crystal |
| BRN | 305601 |
| pKa | 6.49±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.4600 (estimate) |
| MDL | MFCD00597094 |
| Physical and Chemical Properties | Pale yellow crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the rhizome of plant ejaculation. |
| In vitro study | Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Palmitic acid (PA)-stimulated ROS production is abolished by treatment with Tectorigenin for HUVECs in a dose-dependent manner (0.1, 1, 10 μM). Treatment with Tectorigenin attenuates enhanced IKKβ phosphorylation and effectively blocks NF-κB activation by inhibition of p65 phosphorylation at concentrations ranging from 0.1 to 10 μM. Tectorigenin treatment also effectively inhibits PA-augmented TNF-α and IL-6 production in a concentration dependent manner. The number of viable HepG2 cells treated by Tectorigenin decreases in a concentration- and time-dependent manner. When HepG2 cells are treated with Tectorigenin at 5, 10 and 20 mg/L for 24 h, the viability rate is 91%, 79% and 62%, respectively. |
tectorigenin - Risk and Safety
| WGK Germany | 3 |
| RTECS | NR2400000 |
tectorigenin - Reference
| Reference Show more | 1. Bianya, Liu Mengsheng, Zhang Liyuan, et al. Quantitative analysis of six active components in different parts of belamcaria and Iris and its anti-inflammatory effect [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 43(001):119-122. 2. Valkω, Kl · ra. "Application of high-performance liquid chromatography based measurements of obesity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https:// doi.org/10.1016/j.chroma.2003.10.084 3. Valkω, Kl · ra. "Application of high-performance liquid chromatography based measurements of obesity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https://doi.org/10.1016/j.chroma.2003.10.084 4. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884 5. [IF=3.645] Wenjie Wu et al."Simple, rapid and environmentally friendly method for the separation of isoflavones using ultra-high performance supercritical fluid chromatography."J Sep Sci. 2017 Jul;40(13):2827-2837 6. [IF=4.769] Jing Han et al."Qualitative and quantitative evaluation of Flos Puerariae by using chemical fingerprint in combination with chemometrics method."J Pharm Anal. 2021 Sep;: 7. [IF=4.759] Wenjie Wu et al."An analytical strategy for accurate rapid and sensitive quantitative analysis of isoflavones in traditional Chinese medicines using ultra-high performance supercritical fluid chromatography: Take Radix Puerariae as an example."J Chromato 8. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788 9. [IF=3.645] Ziyun Wei et al.Studies on chemical constituents of Flos Puerariae-Semen Hoveniae medicine pair by HPLC and Fourier transform ion cyclotron resonance mass spectrometry.Journal Of Separation Science.2021 Nov 06 10. [IF=6.025] Ruiqian Duan et al."Tectorigenin ameliorated high-fat diet-induced nonalcoholic fatty liver disease through anti-inflammation and modulating gut microbiota in mice."Food Chem Toxicol. 2022 Apr;:112948 |
tectorigenin - Reference Information
| biological activity | Tectorigenin is a plant isoflavone originally isolated from dried flowers of kudzu root soup. |
| in vitro study | Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Palmitic acid (PA)-stimulated ROS production is abolished by treatment with Tectorigenin for HUVECs in a dose-dependent manner (0.1, 1, 10 μM). Treatment with Tectorigenin attenuates enhanced IKKβ phosphorylation and effectively blocks NF-κB activation by inhibition of p65 phosphorylation at concentrations ranging from 0.1 to 10 μM. Tectorigenin treatment also effectively inhibits PA-augmented TNF-α and IL-6 production in a concentration dependent manner. The number of viable HepG2 cells treated by Tectorigenin decreases in a concentration- and time-dependent manner. When HepG2 cells are treated with Tectorigenin at 5, 10 and 20 mg/L for 24 h, the viability rate is 91%, 79% and 62%, respectively. |
| chemical properties | light yellow crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the rhizome of plant ejaculation. |
| uses | ejacanin has antiviral, anti-inflammatory, antipyretic and analgesic effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: it has the effects of clearing away heat and detoxification, relieving pharynx, eliminating phlegm, dispersing blood and reducing swelling |
Last Update：2024-04-09 20:45:29
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