uricase
uricase from bacillus fastidiosus lyoph. white powder
CAS: 9002-12-4
Molecular Formula: C18H26N5O14P
uricase - Names and Identifiers
| Name | uricase from bacillus fastidiosus lyoph. white powder |
| Synonyms | EC 1.7.3.3 URATE OXIDASE |
| CAS | 9002-12-4 |
| EINECS | 232-655-5 |
uricase - Physico-chemical Properties
| Molecular Formula | C18H26N5O14P |
| Molar Mass | 567.397901 |
| Water Solubility | Hardly soluble in water, slightly soluble in buffer alkaline solution. |
| Appearance | lyophilized powder |
| Merck | 13,9944 |
| Storage Condition | -20°C |
| MDL | MFCD00082126 |
| Physical and Chemical Properties | Slightly green crystal or glossy leeches. Almost insoluble in water, slightly soluble in buffer alkaline solution is quite stable in ph7.5 ~ 10.5 solution, has significant absorption effect in 330~350nm region, can be passivated by cyanide ions, and trace amount (10-4mol · L-1) potassium cyanide can inhibit enzyme activity. There are also freeze-dried powder (sodium carbonate as stabilizer), ammonium sulfate suspension and glycerin solution. |
uricase - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | YU7100000 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | Yes |
| HS Code | 35079090 |
uricase - Reference
| Reference Show more | 1. Wan Dongmei, Zheng Yuzhi, long Yijuan, etc. Detection of uric acid based on papain peroxidase mimetic activity [J]. Analysis Laboratory, 2017, 10(v.36):22-25. 2. He Yan, Zeng Xingxing, Li Fang. Rapid analysis of four important physiological indexes in whole blood by paper chip [J]. Guangzhou chemical industry, 2021,49(02):79-82. 3. Shi, W., li, J., wu, J. et al. An electrochemical biosensor based on multi-wall carbon nanotube-modified screen-printed electrode immobilized. Anal Bioanal Chem 412, 7275-7283 (2020). https://doi.org/10.10 4. Wang, X. Y. , et al. "A novel ratiometric fluorescent probe for the detection of uric acid in human blood based on H 2 O 2 -mediated fluorescence quenching of gold/silver nanoclusters." Talanta 191(2019):46-53. 5. [IF=6.057] Jian Wang et al."Label-free and selective sensing of uric acid with gold nanoclusters as optical probe."Talanta. 2016 May;152:314 6. [IF=6.057] Xiao-yan Wang et al."A novel ratiometric fluorescent probe for the detection of uric acid in human blood based on H2O2-mediated fluorescence quenching of gold/silver nanoclusters."Talanta. 2019 Jan;191:46 7. [IF=5.833] Yang Dongqin et al."Gold nanocluster-based ratiometric fluorescent probes for hydrogen peroxide and enzymatic sensing of uric acid."Microchim Acta. 2018 Jun;185(6):1-7 8. [IF=5.833] Zhang Fangmei et al."Enzymatic determination of uric acid using water-soluble CuInS/ZnS quantum dots as a fluorescent probe."Microchim Acta. 2018 Nov;185(11):1-8 9. [IF=6.558] Wenjing Qi et al."Electrochemiluminescence resonance energy transfer immunoassay for alkaline phosphatase using p-nitrophenyl phosphate as substrate."Anal Chim Acta. 2020 Feb;1097:71 10. [IF=6.331] Xiao Liang et al."Urate oxidase loaded in PCN-222(Fe) with peroxidase-like activity for colorimetric detection of uric acid."J Mater Chem B. 2021 Sep;9(34):6811-6817 Note: For some products, we can only provide some information, and we do not guarantee the authority of the information provided, for customer reference and communication purposes only. use: Oxidizes uric acid storage conditions: -20 ℃ Appearance: white powder Inhibitors:Ag ,Hg2 ,Cu2 ,Zn2 ,Fe3, ni2, Co2 Thermal stability:< 65℃ (pH 8.5,10min) pH Stability:6.0~11.0(25℃, 20hr) Optimum temperature:37℃ Optimum pH:8.5 Michaelis constant:1.0×10-5M(Uric acid) Isoelectric point:5.4 Molecular weight:34 kDa (SDS-PAGE) Unit definition:One unit will oxidize one micromole of uric acid at pH 8.5 at 25℃ Per minute. Specific activity:≥10U/mg protein |
uricase - Nature
Open Data Verified Data
This strain was extracted from the fermentation broth of Aspergillus niger or Aspergillus flavus, and the relative molecular mass was 9300. This product is gray-white or brown-green crystal or bright transparent flakes. Practically insoluble in water, slightly soluble in alkaline buffer, isoelectric point pl = 6.3. Cyanide inhibits enzyme activity. It can catalyze the rapid oxidation of uric acid, and eventually produce allantoic acid. Refined uricase injection into the human body, can reduce the uric acid content in the blood, increase allantoic acid excretion in urine, thereby eliminating uric acid retention in the blood and tissues.
Last Update：2024-01-02 23:10:35
uricase - Application
Open Data Verified Data
- clinically used to measure the amount of uric acid in serum and urine. Clinical also used for urinary calculi, nodular gout, renal insufficiency caused by high uric acid.
- usage and dose intramuscular injection or intravenous injection, 1 times a day, each dose prescribed.
Last Update：2025-08-19 16:24:40
uricase - Safety
Open Data Verified Data
visible generalized urticaria itching, local Red intramuscular injection.
Last Update：2022-01-01 11:11:21
uricase - Reference Information
| uricase | fecal acid enzyme is a new type of uric acid lowering drug, also known as Uricase acid, urate oxidase and Urate Oxidase, which is characterized by promoting uric acid decomposition. Catalytic uric acid is rapidly oxidized to become allantoic acid, which is no longer reabsorbed by renal tubules and excreted, thereby reducing the content of uric acid in plasma. For patients who cannot take oral uric acid suppressants. It has a good effect on hyperuricemia caused by uric acid stones, nodular gout, leukemia, renal failure and other factors. |
| chemical properties | slightly green crystals or shiny locust stripes. Almost insoluble in water, slightly soluble in buffer alkaline solution is quite stable in ph7.5 ~ 10.5 solution, has significant absorption effect in 330~350nm region, can be passivated by cyanide ions, and trace amount (10-4mol · L-1) potassium cyanide can inhibit enzyme activity. There are also freeze-dried powder (sodium carbonate as stabilizer), ammonium sulfate suspension and glycerin solution. |
| use | commonly used diagnostic enzymes. Determination of uric acid in serum and urine. It is used for biochemical research and clinically commonly used as a diagnostic enzyme to detect uric acid in serum and urine. uricase is used to determine the amount of uric acid in serum and urine in temporary entertainment. It is also used clinically for the treatment of urinary stones, nodular gout, and hyperuricemia caused by renal insufficiency. But local redness after intramuscular injection, sometimes systemic nettle-like itching can be seen. Intramuscular or intravenous injection, once a day, each dose as prescribed by the doctor. |
| production method | yeast is used as raw material, sodium phosphate is extracted and graded with ammonium sulfate, and then the product is obtained by dialysis, column chromatography and ammonium sulfate recrystallization. |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Last Update：2024-04-09 19:05:04
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