vemlidy
GS-7340 Fumarate
CAS: 379270-38-9
Molecular Formula: C25H33N6O9P
vemlidy - Names and Identifiers
| Name | GS-7340 Fumarate |
| Synonyms | vemlidy GS-7340 Fumarate GS-7340 (fuMarate) Tenofovir alafenamide-19 tenofovir alafenamide fumarate (TAF) |
| CAS | 379270-38-9 |
| EINECS | 223-388-5 |
vemlidy - Physico-chemical Properties
| Molecular Formula | C25H33N6O9P |
| Molar Mass | 592.55 |
| Solubility | DMSO: ≥ 36 mg/mL |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | Tenofovir alafenamide fumarate (GS-7340 fumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT. |
| In vivo study | Tenofovir alafenamide fumarate (GS-7340 fumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF). |
vemlidy - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.688 ml | 8.438 ml | 16.877 ml |
| 5 mM | 0.338 ml | 1.688 ml | 3.375 ml |
| 10 mM | 0.169 ml | 0.844 ml | 1.688 ml |
| 5 mM | 0.034 ml | 0.169 ml | 0.338 ml |
Last Update：2024-01-02 23:10:35
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CAS: 379270-38-9
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Product Name: isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy) phosphoryl) -L-alaninate fumarate Request for quotationCAS: 379270-38-9
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
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Product Name: GS-7340 fumarate Request for quotationCAS: 379270-38-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
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Product Name: Tenofovir alafenamide fumarate Visit Supplier Webpage Request for quotationCAS: 379270-38-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: GS-7340 fumarate Visit Supplier Webpage Request for quotationCAS: 379270-38-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: GS-7340 fumarate Visit Supplier Webpage Request for quotationCAS: 379270-38-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Tenofovir Alafenamide Fumarate Visit Supplier Webpage Request for quotationCAS: 379270-38-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: GS-7340 (fumarate) Visit Supplier Webpage Request for quotation
CAS: 379270-38-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 379270-38-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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