中文名 | 2058264-32-5 |
英文名 | TBK1/IKKε-IN-1 |
别名 | 化合物 T13097 |
英文别名 | -IN-1 2058264-32-5 6-[7-[3-cyano-4-(oxan-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl]-5-methoxy-N,N-dimethylpyridine-3-carboxamide |
CAS | 2058264-32-5 |
化学式 | C28H26N4O5 |
分子量 | 498.53 |
体外研究 | IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response. |