-IN-1
TBK1/IKKε-IN-1
CAS: 2058264-32-5
Molecular Formula: C28H26N4O5
-IN-1 - Names and Identifiers
| Name | TBK1/IKKε-IN-1 |
| Synonyms | -IN-1 2058264-32-5 6-[7-[3-cyano-4-(oxan-4-yloxy)phenyl]furo[3,2-b]pyridin-2-yl]-5-methoxy-N,N-dimethylpyridine-3-carboxamide |
| CAS | 2058264-32-5 |
-IN-1 - Physico-chemical Properties
| Molecular Formula | C28H26N4O5 |
| Molar Mass | 498.53 |
| In vitro study | IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response. |
-IN-1 - References
| biological activity | TBK1/ikkδ-in-1 is a dual TBK1 and ikkε inhibitor with an IC50s value of <100 nM. For detailed information, refer to compound 274 in Example 60 in patent document US20160376283 A1. |
Last Update：2024-04-10 22:29:15
