化合物LU AF21934_化工百科

中文名	Lu AF21934
英文名	Lu AF21934
别名	化合物LU AF21934 (1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二酰胺
英文别名	CS-2215 LU-AF21934 Lu AF21934 LU AF 21934 LU-AF 21934 LU-AF-21934 LU AF-21934 (1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide 1,2-Cyclohexanedicarboxamide, N1-(3,4-dichlorophenyl)-, (1S,2R)-
CAS	1445605-23-1
化学式	C14H16Cl2N2O2
分子量	315.2
密度	1.386±0.06 g/cm3(Predicted)
沸点	577.6±50.0 °C(Predicted)
溶解度	DMSO: ≥ 80 mg/mL
酸度系数	13.23±0.70(Predicted)
存储条件	-20℃
体内研究	Lu AF21934 treatment shows a dose-dependent anxiolytic-like effect in the stress-induced hyperthermia, four-plate, and marble-burying tests. The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test is inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and is not serotonin dependent. Lu AF21934 does not produce antidepressant-like effects in the tail suspension test in mice; however, it decreases the basal locomotor activity of mice that are not habituated to activity cages. Lu AF21934 (0.5-5 mg/kg sc) does not influence tremor but at doses of 0.5 and 2.5 mg/kg reverses harmaline-induced hyperactivity. Lu AF21934 at a dose of 2.5 mg/kg potentiates the inhibitory influence of harmaline on the exploratory activity and AP1 during the first 30 min of the measurement and counteracts the harmaline-increased basic activity during the period of 30-90 min. Lu AF21934 (0.1-5 mg/kg) dose-dependently inhibits hyperactivity induced by MK-801 or amphetamine. It also antagonizes head twitches and increases frequency of spontaneous excitatory postsynaptic currents in brain slices, induced by DOI.

化合物LU AF21934 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.173 ml	15.863 ml	31.726 ml
5 mM	0.635 ml	3.173 ml	6.345 ml
10 mM	0.317 ml	1.586 ml	3.173 ml
5 mM	0.063 ml	0.317 ml	0.635 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

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产品名: Lu AF21934 去供应商网站查看询盘
CAS: 1445605-23-1
产地: 北京
包装: 瓶
规格: IL3290-5mg,5mg
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上海吉至生化科技有限公司

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产品名: Lu AF21934 去供应商网站查看询盘
CAS: 1445605-23-1
产地: 中国上海
包装: 10mg
规格: 99%
价格: 1448.00
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产品描述: 中文名：Lu AF21934 英文名:Lu AF21934 CAS:1445605-23-1 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

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产品名: 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- 去供应商网站查看询盘
CAS: 1445605-23-1
产地: 上海
规格: L861033
价格: 10mg-481,50mg-1292
库存: 7天内发货
电话: 13816333479/13918391375
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上海源叶生物科技有限公司

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产品名: Lu AF21934 去供应商网站查看询盘
CAS: 1445605-23-1
产地: 上海
规格: 98%
价格: 2mg 400,5mg 740,10mg 1250,25mg 2600,50mg 4300,100mg 7500
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