(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide
Lu AF21934
CAS: 1445605-23-1
Molecular Formula: C14H16Cl2N2O2
(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide - Names and Identifiers
(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide - Physico-chemical Properties
| Molecular Formula | C14H16Cl2N2O2 |
| Molar Mass | 315.2 |
| Density | 1.386±0.06 g/cm3(Predicted) |
| Boling Point | 577.6±50.0 °C(Predicted) |
| Solubility | DMSO: ≥ 80 mg/mL |
| pKa | 13.23±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vivo study | Lu AF21934 treatment shows a dose-dependent anxiolytic-like effect in the stress-induced hyperthermia, four-plate, and marble-burying tests. The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test is inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and is not serotonin dependent. Lu AF21934 does not produce antidepressant-like effects in the tail suspension test in mice; however, it decreases the basal locomotor activity of mice that are not habituated to activity cages. Lu AF21934 (0.5-5 mg/kg sc) does not influence tremor but at doses of 0.5 and 2.5 mg/kg reverses harmaline-induced hyperactivity. Lu AF21934 at a dose of 2.5 mg/kg potentiates the inhibitory influence of harmaline on the exploratory activity and AP1 during the first 30 min of the measurement and counteracts the harmaline-increased basic activity during the period of 30-90 min. Lu AF21934 (0.1-5 mg/kg) dose-dependently inhibits hyperactivity induced by MK-801 or amphetamine. It also antagonizes head twitches and increases frequency of spontaneous excitatory postsynaptic currents in brain slices, induced by DOI. |
(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.173 ml | 15.863 ml | 31.726 ml |
| 5 mM | 0.635 ml | 3.173 ml | 6.345 ml |
| 10 mM | 0.317 ml | 1.586 ml | 3.173 ml |
| 5 mM | 0.063 ml | 0.317 ml | 0.635 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: Lu AF21934 Visit Supplier Webpage Request for quotationCAS: 1445605-23-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Lu AF21934 Visit Supplier Webpage Request for quotationCAS: 1445605-23-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History