中文名 | Taprenepag |
英文名 | Taprenepag |
别名 | 化合物TAPRENEPAG 2-(3-((N-(4-(1H-吡唑-1-基)苄基)吡啶-3-磺胺基)甲基)苯氧基)乙酸 |
英文别名 | CP544326 CP-544326 CP 544326 TAPRENEPAG Taprenepag PF 04217329 CP544326 (Taprenepag) Taprenepag(CP-544326) 2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic Acid 2-[3-[[[[4-(1H-Pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]acetic acid |
CAS | 752187-80-7 |
化学式 | C24H22N4O5S |
分子量 | 478.52 |
密度 | 1.34±0.1 g/cm3(Predicted) |
沸点 | 716.8±70.0 °C(Predicted) |
溶解度 | DMSO : ≥ 100 mg/mL (208.98 mM) |
酸度系数 | 3.14±0.10(Predicted) |
存储条件 | Sealed in dry,Room Temperature |
体外研究 | Taprenepag (CP-544326) (0.01-1000 nM) increases cAMP levels in HEK293 cells expressing human EP2 (EC 50 =2.8 nM). Taprenepag has poor corneal permeability in an ex vivo rabbit corneal model. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.09 ml | 10.449 ml | 20.898 ml |
5 mM | 0.418 ml | 2.09 ml | 4.18 ml |
10 mM | 0.209 ml | 1.045 ml | 2.09 ml |
5 mM | 0.042 ml | 0.209 ml | 0.418 ml |
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