升麻素
升麻素(Cimifugin)
CAS: 37921-38-3
化学式: C16H18O6
| 中文名 | 升麻素 |
| 英文名 | Cimifugin |
| 别名 | 升麻素 升麻素对照品 升麻素(标准品) 升麻素, 来源于防风 CIMIFUGIN 升麻素 |
| 英文别名 | CiMitin Cimifugin CIMIFUGIN(P) Cimifugin (Cimitin) (2S)-7-(Hydroxymethyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-5-one 7-(hydroxymethyl)-2-(1-hydroxy-1-methylethyl)-4-methoxy-2,3-dihydro-5H-furo[3,2-g]chromen-5-one (2S)-7-(hydroxymethyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydro-5H-furo[3,2-g]chromen-5-one (S)-2,3-Dihydro-7-(hydroxymethyl)-2-(1-hydroxy-1-methylethyl)-4-methoxy-5H-furo[3,2-g][1]benzopyran-5-one |
| CAS | 37921-38-3 |
| 化学式 | C16H18O6 |
| 分子量 | 306.31 |
| InChI | InChI=1/C16H18O6/c1-16(2,19)13-5-9-11(22-13)6-12-14(15(9)20-3)10(18)4-8(7-17)21-12/h4,6,13,17,19H,5,7H2,1-3H3 |
| 密度 | 1.361±0.06 g/cm3(Predicted) |
| 熔点 | 107～109℃ |
| 沸点 | 546.4±50.0 °C(Predicted) |
| 比旋光度 | +79.2 (c, 0.8 in CHCl3) |
| 闪点 | 204.9°C |
| 蒸汽压 | 8.98E-13mmHg at 25°C |
| 溶解度 | 可溶于甲醇、DMSO等溶剂，不溶于石油醚。 |
| 折射率 | 1.599 |
| 酸度系数 | 14.25±0.29(Predicted) |
| 存储条件 | -20°C |
| 外观 | 白色粉末 |
| 物化性质 | 可溶于甲醇、DMSO等溶剂，不溶于石油醚。 来源于升麻（Cimicifnga foetida L.）根茎 |
| MDL号 | MFCD23105630 |
| 体外研究 | The effect of Cimifugin (Cimitin) on TSLP decreases significantly when expression of CLDN1 is interfered with siRNA and this implied Cimifugin inhibits initiative cytokines through restoring TJs. |
| 体内研究 | Cimifugin (Cimitin; 12.5 or 50 mg/kg/day; intragastrically; 2 days) significantly inhibits TSLP and IL-33 in the initial stage of Mice are sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. Simultaneously, Cimifugin reduces the separated gap among the epithelial cells and increased the expression of TJs. |
| 上游原料 | 升麻苷 |
| 参考资料 展开查看 | 1. 谢静, 李博, 滕飞,等. 应用超滤液相色谱技术筛选中药抑制磷酸二酯酶4活性成分[J]. 化学研究与应用, 2018, 30(11):26-31. 2. [IF=3.046] Menglin Wei et al."Protective effects of a Chotosan Fraction and its active components on β-amyloid-induced neurotoxicity."Neurosci Lett. 2016 Mar;617:143 3. [IF=4.142] Hu Guizhou et al."An integrated strategy for the identification and screening of anti-allergy components from natural products based on calcium fluctuations and cell extraction coupled with HPLC–Q–TOF–MS."Anal Bioanal Chem. 2021 Oct;413(25):6253-6266 4. [IF=2.506] Chen Yuqiu et al."Quality Evaluation of Saposhnikovia divaricata (Turcz.) Schischk from Different Origins Based on HPLC Fingerprint and Chemometrics."J Chem-Ny. 2022;2022:1155650 |
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产品名: 升麻素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IC04101
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提供多种规格现货供应
产品名: 升麻素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IC04101
产地: 北京
包装: 1ml/瓶
规格: IC04101-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
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