CiMitin
Cimifugin
CAS: 37921-38-3
Molecular Formula: C16H18O6
CiMitin - Names and Identifiers
| Name | Cimifugin |
| Synonyms | CiMitin Cimifugin CIMIFUGIN(P) Cimifugin (Cimitin) (2S)-7-(Hydroxymethyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-5-one 7-(hydroxymethyl)-2-(1-hydroxy-1-methylethyl)-4-methoxy-2,3-dihydro-5H-furo[3,2-g]chromen-5-one (2S)-7-(hydroxymethyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydro-5H-furo[3,2-g]chromen-5-one (S)-2,3-Dihydro-7-(hydroxymethyl)-2-(1-hydroxy-1-methylethyl)-4-methoxy-5H-furo[3,2-g][1]benzopyran-5-one |
| CAS | 37921-38-3 |
| InChI | InChI=1/C16H18O6/c1-16(2,19)13-5-9-11(22-13)6-12-14(15(9)20-3)10(18)4-8(7-17)21-12/h4,6,13,17,19H,5,7H2,1-3H3 |
CiMitin - Physico-chemical Properties
| Molecular Formula | C16H18O6 |
| Molar Mass | 306.31 |
| Density | 1.361±0.06 g/cm3(Predicted) |
| Melting Point | 107～109℃ |
| Boling Point | 546.4±50.0 °C(Predicted) |
| Specific Rotation(α) | +79.2 (c, 0.8 in CHCl3) |
| Flash Point | 204.9°C |
| Solubility | Soluble in methanol, DMSO and other solvents, insoluble in petroleum ether. |
| Vapor Presure | 8.98E-13mmHg at 25°C |
| Appearance | White powder |
| pKa | 14.25±0.29(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.599 |
| MDL | MFCD23105630 |
| Physical and Chemical Properties | Soluble in methanol, DMSO and other solvents, insoluble in petroleum ether. Rhizome derived from Cimicifnga foetida L. |
| In vitro study | The effect of Cimifugin (Cimitin) on TSLP decreases significantly when expression of CLDN1 is interfered with siRNA and this implied Cimifugin inhibits initiative cytokines through restoring TJs. |
| In vivo study | Cimifugin (Cimitin; 12.5 or 50 mg/kg/day; intragastrically; 2 days) significantly inhibits TSLP and IL-33 in the initial stage of Mice are sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. Simultaneously, Cimifugin reduces the separated gap among the epithelial cells and increased the expression of TJs. |
CiMitin - Reference
| Reference Show more | 1. Xie Jing, Li Bo, Teng Fei, et al. Screening of phosphodiesterase 4-inhibiting active components from traditional Chinese medicine by ultrafiltration liquid chromatography [J]. Chemical Research and Application, 2018, 30(11):26-31. 2. Menglin Wei et al. [IF = 3.046]. "Protective effects of a chocolate San Fraction and its active components on β-amyloid-induced neurotoxicity." Neurosci Lett. 2016 Mar;617:143 3. [IF = 4.142] Hu Guizhou et al."An integrated strategy for the identification and screening of anti-allergy components from natural products based on calcium fluctuations and cell extraction coupled with HPLC-Q-TOF-MS."Anal Bioanal Chem. 2021 Oct;413(25):6253-6266 4. [IF=2.506] Chen Yuqiu et al."Quality Evaluation of Saposhnikovia divaricata (Turcz.) Schischk from Different Origins Based on HPLC Fingerprint and Chemometrics."J Chem-Ny. 2022;2022:1155650 |
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Product Name: Cimifugin Request for quotation
CAS: 37921-38-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
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CAS: 37921-38-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Cimifugin Visit Supplier Webpage Request for quotationCAS: 37921-38-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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