反式-2-苯基环丙胺半硫酸盐

中文名	Tranylcypromine hemisulfate
英文名	TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE SALT
别名	硫酸反苯环丙胺反苯环丙胺半硫酸盐硫酸反苯环丙胺标准品反-2-苯基环丙基胺半硫酸盐反式-2-苯基环丙胺半硫酸盐 TRANYLCYPROMINE硫酸盐
英文别名	tranylcyprominesulfate tranylcyprominesulphate TRANYLCYPROMINE HEMISULFATE Tranylcypromine hemisulfate Tranylcypromine Sulfate (125 mg) TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE (1R,2S)-rel-2-Phenylcyclopropanamine Sulfate TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE SALT rel-(1R,2S)-2-phenylcyclopropan-1-amine hemisulfate
CAS	13492-01-8
EINECS	236-807-1
化学式	C9H13NO4S
分子量	231.27
InChIKey	BKPRVQDIOGQWTG-FKXFVUDVSA-N
溶解度	易溶于水; 极微溶于乙醇 (96%) 和乙醚。
存储条件	15-25°C
稳定性	从提供的购买之日起稳定1年。蒸馏水中的溶液可以在-20 ° 下储存长达3个月。
外观	白色固体。
颜色	White
体外研究	Tranylcypromine (10 nM to 10 µM) exerts neuroprotective effects against toxicity induced by human Aβ(1-42) oligomers independently from the presence of glial cells. Tranylcypromine (100 μM) significantly protects RGCs from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress. Besides, tranylcypromine contributes to RGC survival via alterations of p38 MAPKγ activity.
体内研究	Tranylcypromine treatment significantly and substantially reduces the lesion size and improves generalized hyperalgesia in a dose-dependent fashion in mice with induced endometriosis. In addition, tranylcypromine treatment results in reduced immunoreactivity to biomarkers of proliferation, angiogenesis, and H3K4 methylation, leading to arrested EMT and lesion growth. Tranylcypromine (500 mM) injection exerts neuroprotective effects within intracellular apoptotic signaling pathways and suppresses morphologic changes in the retina of the rat, suppresses caspase 3 activity and recovers p38 MAPKγ expression in the retina after NMDA-induced injury, and enhances RGC survival after retinal injury via the attenuation of NMDA neurotoxicity. Tranylcypromine (10 µg/g) causes an approximate and significant doubling of labeled cells in the combined brain regions examined, as detected by BrdU immunohistochemistry. Tranylcypromine causes the greatest increase in cell proliferation in the cerebellum.
危险品标志	T - 有毒物品
风险术语	23/24/25 - 吸入、皮肤接触及吞食有毒。
安全术语	S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
危险品运输编号	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	GZ2625000
海关编号	2921490002
Hazard Class	6.1(b)
Packing Group	III
上游原料	硫酸重氮乙酸乙酯氯化亚砜氢氧化钠盐酸叠氮化钠
参考资料展开查看	1: Gahr M, Schönfeldt-Lecuona C, Kölle MA, Freudenmann RW. Intoxications with the monoamine oxidase inhibitor tranylcypromine: an analysis of fatal and non-fatal events. Eur Neuropsychopharmacol. 2013 Nov;23(11):1364-72. doi: 10.1016/j.euroneuro.2013.05.009. Epub 2013 Jun 19. Review. PubMed PMID: 23791433. 2: Krings-Ernst I, Ulrich S, Adli M. Antidepressant treatment with MAO-inhibitors during general and regional anesthesia: a review and case report of spinal anesthesia for lower extremity surgery without discontinuation of tranylcypromine. Int J Clin Pharmacol Ther. 2013 Oct;51(10):763-70. doi: 10.5414/CP201898. Review. PubMed PMID: 23993253. 3: Gahr M, Schönfeldt-Lecuona C, Kölle MA, Freudenmann RW. Withdrawal and discontinuation phenomena associated with tranylcypromine: a systematic review. Pharmacopsychiatry. 2013 Jun;46(4):123-9. doi: 10.1055/s-0032-1333265. Epub 2013 Jan 28. Review. PubMed PMID: 23359339. 4: Iwersen S, Schmoldt A. One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites. J Anal Toxicol. 1996 Sep;20(5):301-4. Review. PubMed PMID: 8872238. 5: Baker GB, Coutts RT, McKenna KF, Sherry-McKenna RL. Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review. J Psychiatry Neurosci. 1992 Nov;17(5):206-14. Review. PubMed PMID: 1362653; PubMed Central PMCID: PMC1188458.

反式-2-苯基环丙胺半硫酸盐 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.744 ml	13.719 ml	27.438 ml
5 mM	0.549 ml	2.744 ml	5.488 ml
10 mM	0.274 ml	1.372 ml	2.744 ml
5 mM	0.055 ml	0.274 ml	0.549 ml

最后更新：2024-01-02 23:10:35

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