柯因
5,7-二羟基黄酮(Chrysin)
CAS: 480-40-0
化学式: C15H10O4
| 中文名 | 5,7-二羟基黄酮 |
| 英文名 | Chrysin |
| 别名 | 柯茵 柯菌 柯因 白杨素 异氧黄酮 白杨黄素 二羟黄酮 5,7-氢黄酮 5,7-二羟黄酮 ,7-二羟基黄酮 纳米脂质体白杨素 5,7-二羟基黄酮 白杨素(分析标准品) |
| 英文别名 | CHRYSIN Chrysin CHRYSINE AKOS NCG1-0026 5,7-Dihydroxyflavone 5,7-DIHYDROXYFLAVONE LABOTEST-BB LT00440772 Chrysin-5,7-dihydroxy Flavone 5,7-DIHYDROXY-2-PHENYL-CHROMEN-4-ONE 5,7-dihydroxy-2-phenyl-4H-chromen-4-one 5,7-dihydroxy-2-phenyl-4H-benzo(b)pyran-4-one 5,7-dihydroxy-2-phenyl-4h-benzo[b]pyran-4-one |
| CAS | 480-40-0 |
| EINECS | 207-549-7 |
| 化学式 | C15H10O4 |
| 分子量 | 254.24 |
| InChI | InChI=1/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H |
| InChIKey | RTIXKCRFFJGDFG-UHFFFAOYSA-N |
| 密度 | 1.2693 (rough estimate) |
| 熔点 | 284-286°C(lit.) |
| 沸点 | 357.45°C (rough estimate) |
| 闪点 | 192.5°C |
| 蒸汽压 | 2.67E-10mmHg at 25°C |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) |
| 折射率 | 1.4872 (estimate) |
| 酸度系数 | 6.50±0.40(Predicted) |
| 存储条件 | Keep in dark place,Sealed in dry,Room Temperature |
| 稳定性 | 稳定。与强氧化剂不相容。 |
| 外观 | 结晶性粉末 |
| 颜色 | Yellow |
| Merck | 14,2256 |
| BRN | 233276 |
| 物化性质 | 浅黄色粉末，室温下溶解丙酮，不溶于水。 |
| MDL号 | MFCD00006834 |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 |
| WGK Germany | 3 |
| RTECS | LK8329050 |
| FLUKA BRAND F CODES | 10 |
| 海关编号 | 29329990 |
| Hazard Class | IRRITANT |
| 上游原料 | 间苯三酚二水合物 |
| 下游产品 | 柚木柯因 |
| 参考资料 展开查看 | 1. 舒雪纯 胡璇 于福来 等. HPLC测定益智仁以及其盐灸炮制品中白杨素和圆柚酮含量[J]. 世界科学技术-中医药现代化 2019 v.21(10):236-241. 2. 李宏伟, 付金芳, 范明松. 白杨素固体脂质纳米粒水凝胶骨架缓释片的制备[J]. 中成药, 2020, 042(003):564-569. 3. 杨金枝,孙文霞,王姣姣,崔锋,郝海军.白杨素固体脂质纳米粒的制备及其药动学行为[J].中成药,2018,40(01):76-80. 4. 穆顺达, 郑国华, 宋成武,等. 白杨素平衡溶解度、油水分配系数及解离常数的测定[J]. 药物分析杂志, 2018, 038(006):997-1004. 5. 崔晓鸽, 曹伶俐, 侯佳威,等. 白杨素磷脂复合物的制备及其药动学行为[J]. 中成药, 2017, 39(005):934-939. 6. 任永申, 邓鑫, 雷蕾,等. 基于抑菌效应成分指纹谱的黄芩质量评价研究[J]. 药学学报, 2019, 054(012):2155-2161. 7. Qian, Suhong, et al. "Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity." Viruses 7.4 (2015): 1613-1626.https://doi.org/10.3390/v7041613 8. Chen, Yan, et al. "Interaction of the main components from the traditional Chinese drug pair Chaihu-Shaoyao based on rat intestinal absorption." Molecules 16.11 (2011): 9600-9610.https://doi.org/10.3390/molecules16119600 9. Yiming Liang, Chen Qu, Ran Yang, Lingbo Qu, Jianjun Li, Molecularly imprinted electrochemical sensor for daidzein recognition and detection based on poly(sodium 4-styrenesulfonate) functionalized graphene, Sensors and Actuators B: Chemical, Volume 251, 201 10. Yanqiu, et al. "Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix. " Journal of pharmaceutical and biomedical analysis 164 11. Shasha Jing, Huijun Zheng, Li Zhao, Lingbo Qu, Lanlan Yu,A novel electrochemical sensor based on WO3 nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin,Talanta,Volume 174 12. [IF=7.808] Jianhua Li et al."Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine."Metab Eng. 2019 Mar;52:124 13. [IF=7.46] Yiming Liang et al."Molecularly imprinted electrochemical sensor for daidzein recognition and detection based on poly(sodium 4-styrenesulfonate) functionalized graphene."Sensor Actuat B-Chem. 2017 Nov;251:542 14. [IF=6.057] Shasha Jing et al."A novel electrochemical sensor based on WO3 nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin."Talanta. 2017 Nov;174:477 15. [IF=4.379] Wang Jinghui et al."A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula."Sci Rep-Uk. 2017 May;7(1):1-22 16. [IF=3.935] Yanqiu Gu et al."Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix."J Pharmaceut Biomed. 2019 Feb;164:550 17. [IF=3.811] Suhong Qian et al."Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity."Viruses-Basel. 2015 Apr;7(4):1613-1626 18. [IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56 19. [IF=3.361] Huanyu Guan et al."Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out 20. [IF=2.57] Shengnan Zhao et al."Chrysin Suppresses Vascular Endothelial Inflammation via Inhibiting the NF-κB Signaling Pathway:."J Cardiovasc Pharm T. 2018;24(3):278-287 21. [IF=1.618] Cui Xiaobing et al."Simultaneous Determination of 10 Flavonoids in Crude and Wine-Processed Radix scutellariae by UHPLC."J Chromatogr Sci. 2016 Mar;54(3):312-317 22. [IF=9.229] Linlin Deng et al."Highly Crystalline Covalent Organic Frameworks Act as a Dual-Functional Fluorescent-Sensing Platform for Myricetin and Water, and Adsorbents for Myricetin."Acs Appl Mater Inter. 2021;13(28):33449–33463 23. [IF=5.64] Ji Xuemeng et al."Function Characterization of Endogenous Plasmids in Cronobacter sakazakii and Identification of p-Coumaric Acid as Plasmid-Curing Agent."Front Microbiol. 2021 Jun;0:1589 24. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051 25. [IF=4.192] Qiangqiang Li et al."Bee Pollen Extracts Modulate Serum Metabolism in Lipopolysaccharide-Induced Acute Lung Injury Mice with Anti-Inflammatory Effects."J Agr Food Chem. 2019;67(28):7855–7868 26. [IF=3.935] Jingyun Zheng et al."A systematic investigation on free phenolic acids and flavonoids profiles of commonly consumed edible flowers in China."J Pharmaceut Biomed. 2019 Aug;172:268 27. [IF=3.216] Taiyang Liao et al."Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats."Drug Des Dev Ther. 2020; 14: 3015–3027 28. [IF=2.447] Fang-Mei Zhou et al."Protective effects of flavonoids from the leaves of Carya cathayensis Sarg. against H2O2‑induced oxidative damage and apoptosis in vitro."Exp Ther Med. 2021 Dec;22(6):1-11 29. [IF=2.408] Bin Ye et al."Protective effects of chrysin against cyclophosphamide-induced cardiotoxicity in rats: A biochemical and histopathological approach."Chemistry & Biodiversity. 2022 Jan 10 30. [IF=3.645] Yu Zhang et al."Qualitative and quantitative analysis of Alpiniae Oxyphyllae fructus by HPLC coupled to Fourier transform-ion cyclotron resonance mass spectrometry."Journal Of Separation Science. 2022 Jan 11 31. [IF=3.935] Junmao Li et al."Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering."J Pharmaceut Biomed. 2022 Mar;211:114621 32. [IF=7.46] Shuo Wang et al."A novel visual sensing method based on Al@AuNCs for rapid identification of Chrysanthemum morifolium from different origins."Sensor Actuat B-Chem. 2022 Apr;356:131307 33. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831 34. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 |
柯因 - 简介
5,7-二羟基黄酮是一种天然存在于许多植物中的黄酮类化合物。它具有以下性质：
外观：5,7-二羟基黄酮是无色或淡黄色的结晶或粉末状固体。
溶解性：5,7-二羟基黄酮略溶于水，可溶于乙醇、乙醚和氯仿等有机溶剂。
稳定性：它在酸性条件下较稳定，但在碱性条件下会发生分解。
化学活性：5,7-二羟基黄酮具有抗氧化、抗炎症和抗肿瘤活性，能够抑制肿瘤细胞的生长和扩散。
5,7-二羟基黄酮的主要用途包括：
制备5,7-二羟基黄酮的一种常用方法是从天然植物中提取和分离。通常使用溶剂（如乙醇或醚类溶剂）萃取植物中的黄酮类化合物，通过提取物的浓缩、结晶和纯化步骤得到目标产物。
安全信息：目前尚无对5,7-二羟基黄酮的毒性研究报道。在使用和处理5,7-二羟基黄酮时，应遵循一般的实验室和化学品安全操作原则，如佩戴个人防护装备、避免吸入和接触皮肤、保持良好的通风等。
外观：5,7-二羟基黄酮是无色或淡黄色的结晶或粉末状固体。
溶解性：5,7-二羟基黄酮略溶于水，可溶于乙醇、乙醚和氯仿等有机溶剂。
稳定性：它在酸性条件下较稳定，但在碱性条件下会发生分解。
化学活性：5,7-二羟基黄酮具有抗氧化、抗炎症和抗肿瘤活性，能够抑制肿瘤细胞的生长和扩散。
5,7-二羟基黄酮的主要用途包括：
制备5,7-二羟基黄酮的一种常用方法是从天然植物中提取和分离。通常使用溶剂（如乙醇或醚类溶剂）萃取植物中的黄酮类化合物，通过提取物的浓缩、结晶和纯化步骤得到目标产物。
安全信息：目前尚无对5,7-二羟基黄酮的毒性研究报道。在使用和处理5,7-二羟基黄酮时，应遵循一般的实验室和化学品安全操作原则，如佩戴个人防护装备、避免吸入和接触皮肤、保持良好的通风等。
最后更新：2024-04-09 21:22:08
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产品名: 白杨素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IC11201
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提供多种规格现货供应
产品名: 白杨素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IC11201
产地: 北京
包装: 1ml/瓶
规格: IC11201-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
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