氟斯必灵
帕罗西汀 杂质C(FLUSPIRILENE)
CAS: 1841-19-6
化学式: C29H31F2N3O
| 中文名 | 帕罗西汀 杂质C |
| 英文名 | FLUSPIRILENE |
| 别名 | 氟虫灵 氟斯必灵 氟司必林 帕罗西汀 杂质C 帕罗西汀EP杂质C 氟司必林 EP标准品 |
| 英文别名 | Redeptin mcn-jr-6218 Fluspirilen FLUSPIRILENE Paroxetine EP IMpurity C FLUSPIRILENE (R6218) DOPAMINE ANTAGONIST 8-(4,4-bis(4-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one R 6218, 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one Fluspirilene,8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one, R 6218 |
| CAS | 1841-19-6 |
| EINECS | 217-418-6 |
| 化学式 | C29H31F2N3O |
| 分子量 | 475.57 |
| 密度 | 1.1634 (estimate) |
| 熔点 | 187.5-190° |
| 沸点 | 668.9±55.0 °C(Predicted) |
| 溶解度 | DMSO: 可溶性 |
| 酸度系数 | 15.05±0.20(Predicted) |
| 存储条件 | room temp |
| 外观 | 无定形固体 |
| 颜色 | white to yellow |
| 体外研究 | Fluspirilene, at concentrations which non-competitively modify dihydropyridine binding, selectively antagonizes the effects of calcium-channel activators. Fluspirilene decreases the viability and suppresses sphere-forming of glioma stem cell lines in a dose-dependent manner. Fluspirilene demonstrates the inhibition of proliferation of T98, U87 and all GSC lines at 1.25, 2.5, and 5 μM, while it inhibits the proliferation of U251 and SNB19 at 2.5 and 5 μM. |
| 体内研究 | Mice treated with fluspirilene shows a remarkable reduction of the tumor size. Fluspirilene significantly prolongs survival of the TGS04 mouse model. |
| 危险品运输编号 | 3249 |
| WGK Germany | 3 |
| RTECS | XX8750000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| 上游原料 | 氯化亚砜 |
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