氯哌斯汀杂质_化工百科

中文名	氯哌斯汀
英文名	cloperastine
别名	咳平咳安定氯哌丁氯哌啶咳安宁氯苯息定氯哌斯汀氯哌斯汀杂质盐酸氯派丁,咳平
英文别名	HT 11 BRN 0275589 cloperastine Cloperastine CLOPERASTINE Cloperastina Cloperastinum UNII-69M5L7BXEK Cloperastine [INN] Cloperastinum [INN-Latin] Cloperastina [INN-Spanish] 5-20-02-00105 (Beilstein Handbook Reference) 1-[2-[p-Chloro-phenylbenzyl)-oxy]ethy]piperidine 1-(2-((4-Chlorophenyl)phenylmethoxy)ethyl)piperidine 1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)-piperidin 1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)piperidine 1-(2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl)piperidine 1-{2-[(4-chlorophenyl)(phenyl)methoxy]ethyl}piperidine 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidin 1- 2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl piperidine 1-{2-((p-Chloro-alpha-phenylbenzyl)oxy)ethyl}piperidine 1-{2-[(p-Chloro-alpha-phenylbenzyl)oxy]ethyl}piperidine Piperidine, 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)- Piperidine, 1-(2-((4-chlorophenyl)phenylmethoxy)ethyl)- (9CI)
CAS	3703-76-2
EINECS	223-042-3
化学式	C20H24ClNO
分子量	329.87
InChI	InChI=1/C20H24ClNO/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22/h1,3-4,7-12,20H,2,5-6,13-16H2
密度	1.0383 (rough estimate)
沸点	bp0.06 172-174°; bp0.15 178-180°
闪点	210.2°C
蒸汽压	2.15E-07mmHg at 25°C
折射率	1.5790 (estimate)
酸度系数	8.69±0.10(Predicted)
存储条件	Room Temprature
物化性质	沸点178-180℃（20Pa），172-174℃（8Pa），其盐酸盐，C20H24CINO·HCI，Hustazol。白色或类白色结晶性粉末。熔点147.9℃。易溶于水、乙醇、氯仿，微溶于丙酮。无臭，味辛基后有麻木感。
上游原料	碳酸钠六氢吡啶 4-氯二苯甲醇
参考资料展开查看	1. [IF=3.591] Meng Li et al."Chiral separation of five antihistamine drug enantiomers and enantioselective pharmacokinetic study of carbinoxamine in rat plasma by HPLC-MS/MS."New J Chem. 2020 Apr;44(15):5819-5827