肝素钠
阿地肝素钠(Heparin sodium)
CAS: 9041-08-1;101921-26-0;102785-31-9;12656-11-0
化学式: ca. (C12H16NS2Na3)20
| 中文名 | 阿地肝素钠 |
| 英文名 | Heparin sodium |
| 别名 | 肝素钠 达肝素钠 肝素钠盐 依诺肝素钠 亭扎肝素钠 肝磷脂钠盐 阿地肝素钠 |
| 英文别名 | Fragmin Sodium Heparin Heparin sodium Ardeparin sodium Dalteparin Sodium Tinzaparin Sodium |
| CAS | 9041-08-1 101921-26-0 102785-31-9 12656-11-0 |
| 化学式 | ca. (C12H16NS2Na3)20 |
| 熔点 | >181°C (dec.) |
| 水溶性 | Soluble in water, dimethyl sulfoxide and ethanol. |
| 溶解度 | 易溶于水(1g溶于20ml水)，溶于盐水溶液，几乎不溶于乙醇、乙醚、丙酮、氯仿和苯。 |
| 存储条件 | 2-8°C |
| 稳定性 | 稳定。与强氧化剂、强碱不相容。 |
| 敏感性 | Hygroscopic |
| 外观 | 结晶性粉末 |
| 物化性质 | 白色或灰棕色无定性粉末，无臭，无味，有吸湿性。易溶于水，不溶于乙醇、乙醚、丙酮和苯等有机溶剂。比旋光度[α]25D+47°(1.5%，水)。
|
| MDL号 | MFCD00081689 |
| 风险术语 | R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R42/43 - 吸入及皮肤接触可能致敏。 |
| 安全术语 | S22 - 切勿吸入粉尘。 |
| WGK Germany | 2 |
| RTECS | MI0850000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| 海关编号 | 30019010 |
| 上游原料 | 硝酸钠 肝素 |
| 下游产品 | 肝素钙 |
| 参考资料 展开查看 | 1. 林沛纯 谌素华 王维民 等. 亨氏马尾藻岩藻聚糖结构鉴定及其对氧化型低密度脂蛋白诱导HMVEC损伤的保护作用[J]. 广东海洋大学学报 2020(5). 2. 李逊, 魏慧梅, 王琴,等. 氨基磺酸法制备硫酸酯化十二指肠糖肽[J]. 生物加工过程, 2018(4). 3. 李慧, 王超, 常忠路,等. 盐酸戊乙奎醚预处理对体外循环相关肺损伤大鼠肺表面活性因子的影响[J]. 中国现代医药杂志, 2020(7):10-13. 4. 梅紫薇, 丁美红, 董莉,等. 黄连提取物中盐酸小檗碱及其单体在家兔体内的药动学差异[J]. 中成药, 2017, 039(008):1605-1608. 5. 王佳茜,赵凯丽,刘万卉.地龙酶解液纯化工艺研究[J].辽宁中医药大学学报,2019,21(11):81-85. 6. 田景睿,李慧,邹玉红,曾荣昌.医用镁合金表面肝素/蒙脱石涂层耐蚀性研究[J].表面技术,2021,50(02):66-73. 7. 赵璐璐,苗鑫,王胜男,高原,谷超,李刚.生草乌及配伍诃子的整合TK-TD模型研究[J].中华中医药杂志,2021,36(02):1012-1019. 8. 李飞. 虫草属真菌转化稀有人参皂苷路径与降脂作用皂苷的筛选及机制研究[D].沈阳农业大学,2021. 9. Pan, Chang-Jiang, et al. "Blood compatibility and interaction with endothelial cells of titanium modified by sequential immobilization of poly (ethylene glycol) and heparin." Journal of Materials Chemistry B 2.7 (2014): 892-902.https://doi.org/10.1039/C3TB 10. [IF=3.368] Sufia Yasmeen et al."A novel approach to devise the therapy for ventricular fibrillation by epicardial delivery of lidocaine using active hydraulic ventricular attaching support system: An experimental study in rats."J Biomed Mater Res B. 2019 Jul;107(5): 11. [IF=6.4] Weipeng Wei et al."Antitumor Effects of Self-Assembling Peptide-Emodin in situ Hydrogels in vitro and in vivo."Int J Nanomed. 2021; 16: 47–60 12. [IF=5.571] Tianxiang Shen et al."The study of intestinal absorption and biodistribution in vivo of proton pump inhibitors."Eur J Pharm Biopharm. 2020 Apr;149:135 13. [IF=5.037] Xindong Jiang et al."An analysis of the biopharmaceutical behaviour of proton pump inhibitors with different physicochemical properties."Life Sci. 2021 Dec;286:120042 14. [IF=4.213] Zhonghui Xie et al."Rapamycin loaded TPGS-Lecithins-Zein nanoparticles based on core-shell structure for oral drug administration."Int J Pharmaceut. 2019 Sep;568:118529 15. [IF=3.216] Jiahao Qian et al."Effects of taurine supplementation in a high-carbohydrate diet on growth performance, plasma biochemical, digestive and glucose metabolism enzymes in hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus)."Aquacult Rep. 2021 No 16. [IF=3] Wan Haoyu et al."Pharmacokinetics of seven major active components of Mahuang decoction in rat blood and brain by LC–MS/MS coupled to microdialysis sampling."N-S Arch Pharmacol. 2020 Aug;393(8):1559-1571 17. [IF=2.408] Wenjing Yu et al."Investigation of the Effects of Squalene and Squalene Epoxides on the Homeostasis of Coenzyme Q10 in Rats by UPLC-Orbitrap MS."Chem Biodivers. 2020 Aug;17(8):e2000243 18. [IF=4.932] Abdoulaye Issotina Zibrila et al.Acetylcholinesterase inhibition with Pyridostigmine attenuates hypertension and neuroinflammation in the paraventricular nucleus in rat model for Preeclampsia.Int Immunopharmacol. 2021 Nov;:108365 19. [IF=6.331] Yuning Zhang et al."Heparinized anticoagulant coatings based on polyphenol-amine inspired chemistry for blood-contacting catheters."J Mater Chem B. 2022 Mar;10(11):1795-1804 20. [IF=5.875] Yutong Wang et al."Extra virgin olive oil-based phospholipid complex/self-microemulsion enhances oral absorption of salvianolic acid B through inhibition of catechol-O-methyltransferase-mediated metabolism."Int J Pharmaceut. 2022 Jan;611:121330 21. [IF=4.451] Pin Gong et al."Protective Effect of Pueraria lobate (Willd.) Ohwi root extract on Diabetic Nephropathy via metabolomics study and mitochondrial homeostasis-involved pathways."J Funct Foods. 2022 May;92:105057 22. [IF=6.832] Zhang Miao et al."Histone chaperone HIRA complex regulates retrotransposons in embryonic stem cells."Stem Cell Res Ther. 2022 Dec;13(1):1-17 |
肝素钠 - 介绍
几乎无臭。无味。为一种天然多糖，取自猪或牛肠粘液或牛肺。1%的水溶液pH为6·0-7·5。半数致死量(大鼠，静脉)354mg/kg。
最后更新：2022-10-16 17:30:01
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