邻苯二酚-4-羧酸

性质

淡黄色至淡褐色非结晶粉末。对热稳定。分d、l两种异构体，混合熔点132℃。溶于水、乙醇、丙二醇、甘油等强极性有机溶剂，不溶于油脂。在碱性介质中易被氧化。l型的熔点为175～177℃，比旋光度[alDo为- 16.8。

制法

将山茶的茎和叶、儿茶树及黑儿茶的叶干馏后，用水或乙醇提取，再经精制而制得。

用途

可用作抗氧化剂。与维生素E、山梨酸、L-抗坏血酸有协同的抗氧化效果。宜配合使用。

中文名	3,4-二羟基苯甲酸
英文名	3,4-Dihydroxybenzoic acid
别名	原儿茶酸原儿茶酸对照品, 原儿茶酸(标准品) 邻苯二酚-4-羧酸 3,4-二羟基苯甲酸原儿茶酸(分析标准品) 原儿茶酸(3,4-二羟基苯甲酸) 原儿茶酸3,4-DIHYDROXYBENZOIC ACID
英文别名	AKOS 220-70 Hypogallic acid Protocatechuic aci RARECHEM AL BO 0347 Protocatechuic acid 3,4-dihydroxybenzoate Carbohydroquinonic acid 3,4-DIHYDROBENZOIC ACID 3,4-Dihydroxybenzoic acid 3,4-Dihydroxy benzoic acid CATECHOL-4-CARBOXYLIC ACID PROTOCATECHUIC ACID N-HYDRATE 3,4-Dihydroxybenzoic acid N-HYDRATE cyclohexa-1,5-diene-1-carboxylic acid Protocatechuic acid, 4-Carboxybenzene-1,2-diol, 4-Carboxycatechol
CAS	99-50-3
EINECS	202-760-0
化学式	C7H6O4
分子量	154.12
InChI	InChI=1/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)/p-1
InChIKey	YQUVCSBJEUQKSH-UHFFFAOYSA-N
密度	1.54
熔点	197-200 °C (dec.) (lit.)
沸点	237.46°C (rough estimate)
闪点	216.3°C
水溶性	Soluble in hot alcohol and ether. Slightly soluble in water.
蒸汽压	1.75E-07mmHg at 25°C
溶解度	20g/l
折射率	1.6400 (estimate)
酸度系数	4.48(at 25℃)
PH值	3.78(1 mM solution);3.25(10 mM solution);2.74(100 mM solution)
存储条件	Store below +30°C.
稳定性	稳定。与强氧化剂、强碱不相容。
敏感性	Air Sensitive
外观	细结晶粉末
颜色	Beige to brown
Merck	14,7894
BRN	1448841
物化性质	原儿茶酸呈白色至微棕色针状结晶状，熔点约200℃（分解）。溶于热水、乙醇和乙醚，微溶于冷水，不溶于苯。在沸水中分解，并放出二氧化碳。水溶液遇三氯化铁呈绿色，遇碳酸氢钠呈暗红色。
MDL号	MFCD00002509
危险品标志	Xi - 刺激性物品
风险术语	36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 S37/39 - 戴适当的手套和护目镜或面具。
WGK Germany	3
RTECS	UL0560000
海关编号	29182990
上游原料	香兰素 3-羟基-4-甲氧基苯甲酸甲酯 4-羟基苯甲酸-2-羟基乙酯香草酸甲酯 2,4-二羟基苯甲酸尼泊金甲酯
下游产品	3,4-二羟基苯甲酸乙酯 3,4-二苄氧基苯甲醛 3,4-二羟基苯甲酸甲酯
参考资料展开查看	1. 张静朱丽莎张耀海等. 不同晚熟柑橘中酚类物质的含量检测及分析[J]. 食品与机械 2018 034(012):27-33. 2. 王彤彤倪青青黄志凌等. 分子印迹电化学传感器测定大气中的羟基自由基[J]. 分析化学 2018 v.46(06):96-102. 3. 郭晓青, 吴金鸿, 刘畅,等. 明日叶的茎与叶主要抗氧化成分含量及抗氧化性比较[J]. 食品与发酵工业, 2013(08):122-127. 4. 董艺凝, 雷小燕, 孙艳辉,等. 滁州薄荷蜂蜜成分与品质分析[J]. 食品与发酵工业, 2019, 45(02):189-193. 5. 张梦雨, 徐洋, 宋冠杉,等. 高效液相色谱-质谱联用法同时测定脑心清原料药浸膏及其片剂中的8种有效成分[J]. 色谱, 2016(8):773-777. 6. 杜迎翔殷蓉朱粉霞徐金娣贾晓斌王慧.UPLC-PDA-QTOF/MS分析肌注胆木注射液后大鼠血浆中的分布[J].中成药 2014 36(11):2339-2344. 7. 赵博,田恒康,孙道涵,申立峰,孔静,路东波,李文霞,武秋红,刘璐,李倩,张元元,吕珊,陈梦杰,石任兵.基于酚类特征图谱的山楂质量表征关联分析研究[J].北京中医药大学学报,2017,40(08):684-692. 8. 黑青稞麸皮结合态酚类物质大孔树脂分离纯化工艺优化 9. 刘勇付小凯李阳等. HPLC法同时测定半枝莲中原儿茶酸和香草酸的含量[J]. 化学分析计量 2015(4):20-22. 10. 金银萍艾军王振兴等. 不同种质资源五味子藤茎酚酸类成分的含量测定[J]. 中药材 2018 41(002):322-324. 11. 齐乐辉, 李嘉欣, 孟鑫,等. 基于HPLC法对加入厚朴后广藿香水溶性物质的含量影响研究[J]. 化学工程师, 2020, 034(004):19-21,8. 12. 齐乐辉, 陈悦, 孟鑫,等. 基于HPLC法测定广藿香水提物中香草酸及原儿茶酸的含量研究[J]. 化学工程师, 2020, 034(003):22-24. 13. 齐乐辉, 龙丹丹, 孟鑫,等. 基于HPLC法研究广藿香中加入陈皮后水溶性成分的变化规律[J]. 化学工程师, 2020, v.34;No.296(05):42-44+48. 14. 齐乐辉, 范鑫玉, 王丹,等. 基于正交试验对广藿香加热回流提取条件的优化[J]. 科学技术创新, 2019, 000(024):P.22-23. 15. 徐锋, 杨烨, 舒秋娥,等. 大血藤的HPLC指纹图谱[J]. 中国实验方剂学杂志, 2013. 16. 徐锋, 杨烨, 舒秋娥,等. 大血藤药材的UPLC指纹图谱分析[J]. 中国实验方剂学杂志, 2013. 17. 梁光斐, 张煜, 王娇,等. 高效液相色谱结合化学计量学的广藿香提取物指纹图谱研究[J]. 贵州科学, 2018, 036(004):71-76. 18. 梅余琪, 魏丽芳, 邹立思,等. 鸡血藤中多元活性成分动态积累的分析与评价[J]. 中国中药杂志, 2020, v.45(03):134-145. 19. 梅余琪, 魏丽芳, 邹立思,等. 鸡血藤韧皮部环数与多指标成分的相关性分析[J]. 分析测试学报, 2020(8):941-949. 20. 沈经纬刘畅白一丹等. 五凤草液的HPLC指纹图谱建立与有效部位的质量控制[J]. 海峡药学 2020 032(004):39-44. 21. 郭晓青, 韦隆华, 代甜甜,等. 水芹化学成分检测及降血糖作用[J]. 食品与机械, 2017(1). 22. 王聪付士朋金司阳等. 不同产地刺五加果实中5种活性成分的含量测定及聚类分析[J]. 时珍国医国药 2019 v.30;No.288(08):196-198. 23. 胡耀辉于晓明王玉华等. 不同豆浆制备工艺活性成分与ABTS自由基清除能力比较研究[J]. 粮油加工(电子版) 2015(04):47-51. 24. 金银萍曲正义崔丽丽等. 五味子不同部位黄酮和酚酸类成分的含量测定及抗氧化活性[J]. 中国实验方剂学杂志 2018(19). 25. 张元元,吕珊,陈梦杰,孔静,孙仁弟,张媛媛,路东波,武秋红,李文霞,王梦林,范圆圆,冯鑫,李思潼,黄玉娟,姜艳艳,石任兵.沙棘酚类特征成分含量测定及其特征图谱质量表征关联分析研究[J].北京中医药大学学报,2018,41(05):383-394. 26. 朱金帅,李秋莹,于昕睿,孙彤,励建荣.酚酸对水产品腐败希瓦氏菌的抑菌作用[J].食品与机械,2020,36(06):133-137. 27. 黄莎莎赵文静张悦等. 中药酚酸类成分在PES膜分离过程中的透过机制研究[J]. 中国中药杂志 2020 v.45(01):114-120. 28. 朱伟赵赫姚岚等. UFLC-MS/MS法同时测定肺宁颗粒中6种化学成分[J]. 解放军药学学报 2017(04):356-358. 29. 张爽付士朋刘悦等. HPLC法分析刺五加茎中原儿茶酸及苯丙素类成分动态累积规律研究[J]. 天然产物研究与开发 2018(8):1410-1414. 30. 王娇徐家怡左雅敏等. HPLC法同时测定五味藿香片中6种成分[J]. 中成药 2018 40(10). 31. 路滨键, 于克可, 张玉刚,等. 红肉苹果营养成分及生物活性物质分析[J]. 青岛农业大学学报(自然科学版), 2018, v.35;No.128(01):13-19. 32. 李莉, 孙宜春, 庞媛媛,等. 陈皮水提物指纹图谱的化学计量学分析及与糖尿病认知功能障碍的谱效关系[J]. 中国实验方剂学杂志, 2020(1). 33. 赵玥, 齐越, 单国顺,等. 不同产地火绒草HPLC指纹图谱的建立及化学模式识别[J]. 中成药, 2019, 041(004):849-854. 34. 王新然, 刘瑶, 张晓瑞,等. 核桃瓣膜提取物组成、体外抗氧化性及其对羊肉保鲜作用分析[J]. 食品与发酵工业, 2019, 045(010):78-85. 35. 陈梦杰, 李文霞, 李思潼,等. 蒲公英酚类特征成分含量测定及其特征图谱质量表征关联分析[J]. 中国实验方剂学杂志, 2018, 024(016):12-20. 36. 李俊卢汝梅黎云清等. HPLC法同时测定九龙盘中6种成分[J]. 中成药 2020 v.42(05):126-130. 37. 黄赵刚, 程钢, 汤浩,等. 血必净注射液指纹图谱研究[J]. 中国医院药学杂志, 2018, 038(022):2323-2327. 38. 虞小静, 张冬月, 李思雨,等. 天麻水提物HPLC指纹图谱的建立及其真伪鉴别[J]. 中成药, 2018, 40(12):2698-2702. 39. 赵艺楠, 宋科, 彭胜,等. 沸石分子筛吸附分离忽地笑中石蒜碱[J]. 天然产物研究与开发, 2016, 028(002):289-292,299. 40. 杨希娟, 党斌, 樊明涛. 溶剂提取对青稞中不同形态多酚组成及抗氧化活性的影响[J]. 食品科学, 2018, 39(24):246-255. 41. 牛敏刘红燕刘谦等. 4个栽培年限丹参颜色与9种活性成分含量的相关性[J]. 中成药 2017(1):131-135. 42. 李俊萍, 付士朋, 王谦博,等. 多指标综合评价刺五加叶适宜采收期的研究[J]. 中草药, 2019, v.50;No.648(13):196-201. 43. 徐菲, 杨希娟, 党斌,等. 酸法提取青稞麸皮结合酚工艺优化[J]. 农业工程学报, 2016, 32(017):301-308. 44. 郄佩娟, 段旭昌, 王敏,等. 长裂苦苣菜甲醇提取物各极性成分的抗氧化活性研究[J]. 食品工业科技, 2016, 37(16):146-150. 45. 汤晓叶庄新余伟等. 南瓜酚类物质及抗氧化活性受烹饪方式的影响[J]. 食品科技 2016 041(005):223-228. 46. 范琳琳, 王英, 黄自苏,等. 外源添加物质对黑莓清汁花色苷稳定性和抗氧化活性的影响[J]. 食品工业科技, 2019, v.40;No.420(04):62-67. 47. 金司阳, 刘寒, 杨立学,等. 植物-土壤反馈对刺五加幼苗次生代谢产物的影响[J]. 中国实验方剂学杂志, 2020. 48. 孔宇, 张倚菲, 韩鹏云,等. 沙棘籽粕多酚提取工艺优化,组分分析及抗氧化性能研究[J]. 中国油脂, 2020, 045(004):109-114. 49. 王奕芳,温承坤,陈茂彬,张玉,李琴,方尚玲.麻城老米酒中酚类物质的初探[J].中国酿造,2019,38(12):175-178. 50. 王婷婷, 苑伟, 李华,等. 复合小浆果果酒中的酚类物质及其抗氧化活性分析[J]. 食品与发酵工业, 2019, 45(03):183-188. 51. 张艺沛, 张婷, 史一恒,等. 藜麦茶加工工艺及酚类物质组成分析[J]. 食品科学, 2019, 040(012):267-274. 52. 贾萌,王洪兰,赵晓莉,张雯,池玉梅,狄留庆.不同产地蔓荆子HPLC指纹图谱及模式识别研究[J].中华中医药杂志,2020,35(12):6306-6309. 53. 陈佳丽,谈梦霞,邹立思,刘训红,陈舒妤,石婧婧,王程成,梅余琪.超快速液相色谱-三重四级杆/线性离子阱质谱法同时测定不同产地竹节参药材中多元成分[J].中国药学杂志,2019,54(03):226-233. 54. 李承浩,王萌,任晓亮.磺化杯6芳烃对4类中药单体成分增溶作用及其机制研究[J].中国现代中药,2020,22(12):2032-2038. 55. 王宇卿,李淑娇,庄果.基于HPLC-Q-TOF/MS法的鬼针草血清药物化学探究[J].中成药,2020,42(11):3074-3078. 56. 徐艳阳,赵玉娟,高峰,王二雷,鲁海玲,李雪凤,姜雯雯,陈艳.高效液相色谱法分析中国人参不同部位中多酚类化合物[J].食品科学,2021,42(04):240-246. 57. 梅余琪,魏丽芳,邹立思,刘训红,陈佳丽,谈梦霞,王程成,蔡芷辰,殷圣鑫,张芙蓉.鸡血藤韧皮部环数与多指标成分的相关性分析[J].分析测试学报,2020,39(08):941-949. 58. 赵萌萌,张文刚,党斌,杨希娟,张杰,甘生智.超微粉碎对青稞麸皮粉多酚组成及抗氧化活性的影响[J].农业工程学报,2020,36(15):291-298. 59. Zhang, Jing, et al. "Application of “spider-web” mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule." Phytomedicine 77 (2020): 153273.https://doi.org/10.1016/j.phymed.2020.153273 60. Zhong, Ke, and Tingting Yang. "Study on HPLC Fingerprint of Dendrobium Nobile Lindl. Flower Based on Chemometrics." IOP Conference Series: Earth and Environmental Science. Vol. 651. No. 3. IOP Publishing, 2021.https://doi.org/10.1088/1755-1315/651/3/032027 61. Hu, Ruizhi, et al. "Dietary protocatechuic acid ameliorates inflammation and up-regulates intestinal tight junction proteins by modulating gut microbiota in LPS-challenged piglets." Journal of animal science and biotechnology 11.1 (2020): 1-12.https://doi. 62. Fenxia Zhu, Jiaquan Chen, Hui Wang, Xiaobin Jia, Shuxia Wang, Zhiyuan Zhang, Xiaoting Zhai, Jindi Xu, Wei Tan, Qing Ning, Junfei Gu,Analysis of the chemical constituents and rats metabolites after oral administration of Nauclea officinalis by ultra-perfor 63. Cheng, Yan, et al. "Decomposition of five phenolic compounds in high temperature water." Journal of the Brazilian Chemical Society 25 (2014): 2102-2107.https://doi.org/10.5935/0103-5053.20140201 64. Zheng, Yuting, et al. "Antioxidant, α-amylase and α-glucosidase inhibitory activities of bound polyphenols extracted from mung bean skin dietary fiber." LWT 132 (2020): 109943.https://doi.org/10.1016/j.lwt.2020.109943 65. Dong, Qingying, et al. "Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods." Journal of Food Measurement and Characterization 13.4 (2019): 3198-3205.https://doi.org/10. 66. Dong, Qingying, et al. "Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods." Journal of Food Measurement and Characterization 13.4 (2019): 3198-3205.https://doi.org/10. 67. Zhang, Xianhua, et al. "Danshen-Chuanxiong-Honghua ameliorates cerebral impairment and improves spatial cognitive deficits after transient focal ischemia and identification of active compounds." Frontiers in pharmacology 8 (2017): 452. 68. Zhang, Xianhua, et al. "Danshen-Chuanxiong-Honghua ameliorates cerebral impairment and improves spatial cognitive deficits after transient focal ischemia and identification of active compounds." Frontiers in pharmacology 8 (2017): 452. 69. Wei, Jianping, et al. "Assessment of chemical composition and sensorial properties of ciders fermented with different non-Saccharomyces yeasts in pure and mixed fermentations." International journal of food microbiology 318 (2020): 108471.https://doi.org/1 70. Chen, Yazhen, et al. "Effect of roasting and in vitro digestion on phenolic profiles and antioxidant activity of water-soluble extracts from sesame." Food and Chemical Toxicology 139 (2020): 111239.https://doi.org/10.1016/j.fct.2020.111239 71. Wei, Yulong, et al. "Exploring the biochemical properties of three polyphenol oxidases from blueberry (Vaccinium corymbosum L.)." Food Chemistry 344 (2021): 128678.https://doi.org/10.1016/j.foodchem.2020.128678 72. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 73. [IF=4.411] Jun Cao et al."Tailor-Made Deep Eutectic Solvents for Simultaneous Extraction of Five Aromatic Acids from Ginkgo biloba Leaves."Molecules. 2018 Dec;23(12):3214 74. [IF=3.845] Zhang Xianhua et al."Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds."Front Pharmacol. 2017 Jul;0:452 75. [IF=3.757] Yuchen Wang et al."Metabolic profile of ginkgo kernel juice fermented with lactic aicd bacteria: A potential way to degrade ginkgolic acids and enrich terpene lactones and phenolics."Process Biochem. 2019 Jan;76:25 76. [IF=3.571] Lin Han et al."Protocatechuic Acid Ameliorated Palmitic-Acid-Induced Oxidative Damage in Endothelial Cells through Activating Endogenous Antioxidant Enzymes via an Adenosine-Monophosphate-Activated-Protein-Kinase-Dependent Pathway."J Agr Food Chem. 2018;6 77. [IF=3.205] Fenxia Zhu et al."Analysis of the chemical constituents and rats metabolites after oral administration of Nauclea officinalis by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry."J Chromatogr B. 2015 Dec;1007:54 78. [IF=3.205] Xianhua Zhang et al."Pharmacokinetic study of representative anti-oxidative compounds from Denshen-Chuanxiong-Honghua following oral administration in rats."J Chromatogr B. 2017 May;1052:82 79. [IF=7.514] Jinxue Hou et al."Variations in phenolic acids and antioxidant activity of navel orange at different growth stages."Food Chem. 2021 Oct;360:129980 80. [IF=7.514] Hongcai Li et al."Study on the nutritional characteristics and antioxidant activity of dealcoholized sequentially fermented apple juice with Saccharomyces cerevisiae and Lactobacillus plantarum fermentation."Food Chem. 2021 Nov;363:130351 81. [IF=7.514] Xiaoming Yu et al."Impact of processing technologies on isoflavones, phenolic acids, and antioxidant capacities of soymilk prepared from 15 soybean varieties."Food Chem. 2021 May;345:128612 82. [IF=7.132] Li Yang et al."Supercritical extraction and antioxidant activity of major ingredients in Puerariae lobatae root, Pinus massoniana needle, Citrus reticulata peel and their mixture."J Co2 Util. 2021 Jun;48:101518 83. [IF=6.023] Yazhen Chen et al."Effect of roasting and in vitro digestion on phenolic profiles and antioxidant activity of water-soluble extracts from sesame."Food Chem Toxicol. 2020 May;139:111239 84. [IF=5.81] Chenning Zhang et al."Global Analysis the Potential Medicinal Substances of Shuangxia Decoction and the Process In Vivo via Mass Spectrometry Technology."Front Pharmacol. 2021; 12: 654807 85. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro 86. [IF=5.396] Binkai Han et al."Ultrasound-assisted enzymatic extraction of Corni Fructus alpha-glucosidase inhibitors improves insulin resistance in HepG2 cells."Food Funct. 2021 Oct;12(20):9808-9819 87. [IF=5.396] Ruihong Dong et al."Release and metabolism of bound polyphenols from carrot dietary fiber and their potential activity in in vitro digestion and colonic fermentation."Food Funct. 2020 Jul;11(7):6652-6665 88. [IF=5.34] Jing Zhang et al."Application of “spider-web” mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule."Phytomedicine. 2020 Oct;77:153273 89. [IF=5.277] Jianping Wei et al."Assessment of chemical composition and sensorial properties of ciders fermented with different non-Saccharomyces yeasts in pure and mixed fermentations."Int J Food Microbiol. 2020 Apr;318:108471 90. [IF=5.165] Huan Zhang et al."Fermentation characteristics and the dynamic trend of chemical components during fermentation of Massa Medicata Fermentata."Arab J Chem. 2022 Jan;15:103472 91. [IF=4.952] Yuan Yuan et al."Diversity of phenolics including hydroxycinnamic acid amide derivatives, phenolic acids contribute to antioxidant properties of proso millet."Lwt Food Sci Technol. 2022 Jan;154:112611 92. [IF=4.952] Yuting Zheng et al."Antioxidant, α-amylase and α-glucosidase inhibitory activities of bound polyphenols extracted from mung bean skin dietary fiber."Lwt Food Sci Technol. 2020 Oct;132:109943 93. [IF=4.952] Shuxin Tang et al."Effect of Lactobacillus plantarum-fermented mulberry pomace on antioxidant properties and fecal microbial community."Lwt Food Sci Technol. 2021 Jul;147:111651 94. [IF=4.952] Guanyi Peng et al."Combined microwave and enzymatic treatment improve the release of insoluble bound phenolic compounds from the grapefruit peel insoluble dietary fiber."Lwt Food Sci Technol. 2021 Sep;149:111905 95. [IF=4.952] Yuxin Hao et al."Stability and mechanism of phenolic compounds from raspberry extract under in vitro gastrointestinal digestion."Lwt Food Sci Technol. 2021 Mar;139:110552 96. [IF=4.411] Yuqi Mei et al."A Method to Study the Distribution Patterns for Metabolites in Xylem and Phloem of Spatholobi Caulis."Molecules. 2020 Jan;25(1):167 97. [IF=4.411] Tao Tian et al."Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose."Molecules. 2021 Jan;26(15):4638 98. [IF=4.35] Qian Ge et al."Effects of Simultaneous Co-Fermentation of Five Indigenous Non-Saccharomyces Strains with S. cerevisiae on Vidal Icewine Aroma Quality."Foods. 2021 Jul;10(7):1452 99. [IF=4.24] Nana Li et al."Characterization of phenolic compounds and anti-acetylcholinase activity of coconut shells."Food Biosci. 2021 Aug;42:101204 100. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 101. [IF=3.935] Jingyun Zheng et al."A systematic investigation on free phenolic acids and flavonoids profiles of commonly consumed edible flowers in China."J Pharmaceut Biomed. 2019 Aug;172:268 102. [IF=3.935] Yong-Sheng Wu et al."Chemical profiling of Callicarpa nudiflora and its effective compounds identification by compound-target network analysis."J Pharmaceut Biomed. 2020 Apr;182:113110 103. [IF=3.935] Yuqi Mei et al."Qualitative and quantitative analysis of the major constituents in Spatholobi Caulis by UFLC-Triple TOF-MS/MS and UFLC-QTRAP-MS/MS."J Pharmaceut Biomed. 2021 Feb;194:113803 104. [IF=3.638] Tao Bao et al."Green alternative methods for pretreatment of whole jujube before the drying process."Journal Of The Science Of Food And Agriculture. 2021 Aug 11 105. [IF=3.571] Lin Han et al."Protocatechuic Acid-Ameliorated Endothelial Oxidative Stress through Regulating Acetylation Level via CD36/AMPK Pathway."J Agr Food Chem. 2019;67(25):7060–7072 106. [IF=3.493] Min Lu et al."Preparation of phytic acid modified α-Glucosidase/Cu3(PO4)2·3H2O hybrid nanoflower and its application."Enzyme Microb Tech. 2021 May;146:109776 107. [IF=3.411] Shi Guiqin et al."UPLC-ESI-MS/MS Analysis and Evaluation of Antioxidant Activity of Total Flavonoid Extract from Paeonia lactiflora Seed Peel and Optimization by Response Surface Methodology (RSM)."Biomed Res Int. 2021;2021:7304107 108. [IF=2.863] Jie Hu et al."Tracking the dynamic changes of a flavor, phenolic profile, and antioxidant properties of Lactiplantibacillus plantarum- and Saccharomyces cerevisiae-fermented mulberry wine."Food Sci Nutr. 2021 Nov;9(11):6294-6306 109. [IF=2.863] Qiaoran Zheng et al."Optimizing synchronous extraction and antioxidant activity evaluation of polyphenols and polysaccharides from Ya'an Tibetan tea (Camellia sinensis)."Food Sci Nutr. 2020 Jan;8(1):489-499 110. [IF=2.72] Wenfeng Li et al."Citric acid-enhanced dissolution of polyphenols during soaking of different teas."J Food Biochem. 2019 Dec;43(12):e13046 111. [IF=2.431] Dong Qingying et al."Comparative study on phenolic compounds, triterpenoids, and antioxidant activity of Ganoderma lucidum affected by different drying methods."J Food Meas Charact. 2019 Dec;13(4):3198-3205 112. [IF=4.215] Ma Junqing et al."Mycorrhizal symbiosis promotes the nutrient content accumulation and affects the root exudates in maize."Bmc Plant Biol. 2022 Dec;22(1):1-13 113. [IF=6.576] Jie Yang et al."Fermentation and Storage Characteristics of “Fuji” Apple Juice Using Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus plantarum: Microbial Growth, Metabolism of Bioactives and in vitro Bioactivities."Front Nutr. 2022; 9: 83 114. [IF=3.645] Yu Zhang et al."Qualitative and quantitative analysis of Alpiniae Oxyphyllae fructus by HPLC coupled to Fourier transform-ion cyclotron resonance mass spectrometry."Journal Of Separation Science. 2022 Jan 11 115. [IF=7.312] Yun Zhang et al."Insights into the penetration of PhACs in TCM during ultrafiltration: Effects of fouling mechanisms and intermolecular interactions."SEPARATION AND PURIFICATION TECHNOLOGY. 2022 Aug;295:121205 116. [IF=4.35] Xi Chen et al."Comparison and Optimization of Different Extraction Methods of Bound Phenolics from Jizi439 Black Wheat Bran."Foods. 2022 Jan;11(10):1478 117. [IF=4.412] Hui-Min Jin et al."Polyphenol and Anthocyanin Composition and Activity of Highland Barley with Different Colors."MOLECULES. 2022 Jan;27(11):3411 118. [IF=3.361] Jia Cheng et al."A new method for simultaneous determination of 14 phenolic acids in agricultural soils by multiwavelength HPLC-PDA analysis."RSC Advances. 2022 May;12(23):14939-14944 119. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 120. [IF=4.24] Jun Li et al."In vitro xanthine oxidase inhibitory properties of Flos Sophorae Immaturus and potential mechanisms."Food Biosci. 2022 Jun;47:101711 121. [IF=6.475] Yang Zhang et al."Effect of geographical location and soil fertility on main phenolic compounds and fatty acids compositions of virgin olive oil from Leccino cultivar in China."Food Res Int. 2022 Jul;157:111207 122. [IF=3.645] Lewen Xiong et al."Study on phenolic acids of Lonicerae japonicae Flos based on ultrahigh performance liquid chromatography-tandem mass spectrometry combined with multivariate statistical analysis."JOURNAL OF SEPARATION SCIENCE

邻苯二酚-4-羧酸 - 性质

可信数据

最后更新：2024-01-02 23:10:35

邻苯二酚-4-羧酸 - 制法

可信数据

将山茶的茎和叶、儿茶树及黑儿茶的叶干馏后，用水或乙醇提取，再经精制而制得。

最后更新：2022-01-01 11:13:14

邻苯二酚-4-羧酸 - 介绍

药理药效：本品具有抗菌作用，体外试验时对绿脓杆菌、大肠杆菌、伤寒杆菌、痢疾杆菌、产碱杆菌及枯草杆菌和金黄色葡萄球菌均有不同程度的抑菌作用。亦有祛痰、平喘作用。临床用于治疗慢性气管炎。

最后更新：2022-10-16 17:30:31

邻苯二酚-4-羧酸 - 用途

可信数据

可用作抗氧化剂。与维生素E、山梨酸、L-抗坏血酸有协同的抗氧化效果。宜配合使用。

最后更新：2022-01-01 11:13:14

邻苯二酚-4-羧酸 - 简介

3,4-二羟基苯甲酸是一种有机化合物。以下是关于它的性质、用途、制法和安全信息的介绍：

性质：
- 外观：3,4-二羟基苯甲酸呈白色或类白色结晶粉末。
- 溶解性：它在水中溶解度较低，但在有机溶剂如乙醇、醚和酯中溶解性较好。

用途：
- 色素制备：其具有羟基和羧基的反应活性，3,4-二羟基苯甲酸可用于制备染料和颜料。

制法：
- 3,4-二羟基苯甲酸可通过对间苯二酚和碳酸钠或碳酸氢钠进行酯交换反应得到。

安全信息：
* 接触：避免直接接触眼睛、皮肤和粘膜。如意外接触，应立即用大量清水冲洗。
* 吸入：避免长时间吸入粉尘或溶液的蒸气，应在通风良好的环境下操作。
* 食入：不应食用或饮用3,4-二羟基苯甲酸。
* 储存：应将其储存在干燥、阴凉、通风的地方，远离火源和氧化剂。

最后更新：2024-04-09 21:04:16

上海石洋化工有限公司

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武汉吉鑫益邦生物科技有限公司

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巴师傅（上海）生物医药科技有限公司

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前衍化学科技（武汉）有限公司

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CAS: 99-50-3
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包装: 500g, 1kg, 10kg, 100kg
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江苏博思特化工科技有限公司

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北京索莱宝科技有限公司

提供多种规格现货供应

产品名: 3,4-二羟基苯甲酸(10mM in DMSO,无菌) 去供应商网站查看询盘
CAS: IP11501
产地: 北京
包装: 1ml/瓶
规格: IP11501-1ml
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库存: 现询
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江苏润丰合成科技有限公司

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江苏普乐司生物科技有限公司

产品名: 3,4-二羟基苯甲酸询盘
CAS: 99-50-3
产地: 江苏
电话: 17505222756
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产品描述: 普乐司成立于2015年，是一家集研发、生产、销售服务于一体的科技型企业。我司的核心业务团队已有近十年的行业服务经验，我们将秉持“责任、高效、创新”的理念竭诚为您更多

上海吉至生化科技有限公司

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产品名: 原儿茶酸去供应商网站查看询盘
CAS: 99-50-3
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包装: 5g
规格: ≥97%(HPLC)
价格: 39.00
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产品描述: 中文名：原儿茶酸英文名:Protocatechuic acid CAS:99-50-3 规格:≥97%(HPLC) 产地:中国上海

上海麦克林生化科技股份有限公司

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CAS: 99-50-3
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