鸟苷
鸟嘌呤核苷(Guanosine hydrate)
CAS: 118-00-3
化学式: C10H13N5O5
| 中文名 | 鸟嘌呤核苷 |
| 英文名 | Guanosine hydrate |
| 别名 | 鸟甙 鸟苷 鸟粪苷 鸟粪素苷 鸟嘌呤核苷 二水合鸟苷 鸟苷(二水) 鸟嘌呤呋喃核苷 |
| 英文别名 | GR Guanosine usafcb-11 GUANOSINE D-GUANOSINE Guanine riboside GUANINE RIBOSIDE Guanosine hydrate guanosine cell culture tested 9-[BETA-D-RIBOFURANOSYL]GUANINE GUANINE-9-BETA-D-RIBOFURANOSIDE O-(BETA-D-RIBOFURANOSYL)GUANINE Guanosine Guanine 9-B-D-ribofuranoside 2-amino-9-pentofuranosyl-3,9-dihydro-6H-purin-6-one 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one 2-amino-9-(beta-D-xylofuranosyl)-3,9-dihydro-6H-purin-6-one 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one hydrate 2-amino-9-(alpha-D-xylofuranosyl)-3,9-dihydro-6H-purin-6-one |
| CAS | 118-00-3 |
| EINECS | 204-227-8 |
| 化学式 | C10H13N5O5 |
| 分子量 | 283.24 |
| InChI | InChI=1/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5+,6-,9+/m1/s1 |
| InChIKey | NYHBQMYGNKIUIF-UUOKFMHZSA-N |
| 密度 | 1.3790 (rough estimate) |
| 熔点 | 250 °C (dec.) (lit.) |
| 沸点 | 425.8°C (rough estimate) |
| 比旋光度 | -62 º (c=3, in 0.1 N NaOH) |
| 闪点 | 423.1°C |
| 水溶性 | 0.75 g/L (25 ºC) |
| 蒸汽压 | 2.44E-25mmHg at 25°C |
| 溶解度 | 0.1 M NaOH: 0.1g/ml，澄清，微溶带黄色 |
| 折射率 | -76 ° (C=1, 1mol/L N |
| 酸度系数 | pK1:1.9(＋1);pK2:9.25(0);pK3:12.33(OH) (25°C) |
| 存储条件 | room temp |
| 外观 | 粉末 |
| 颜色 | White to light yellow |
| 气味 | Odorless |
| Merck | 14,4566 |
| BRN | 625911 |
| 物化性质 | 白色或类白结晶性粉末。熔点250℃。 |
| MDL号 | MFCD00010182 |
| 危险品标志 | T - 有毒物品 Xi - 刺激性物品  |
| 风险术语 | 25 - 吞食有毒。 |
| 安全术语 | S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S24/25 - 避免与皮肤和眼睛接触。 S23 - 切勿吸入蒸汽。 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | MF8750000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| 海关编号 | 29349990 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
| 下游产品 | 利巴韦林 5'-鸟苷酸二钠 5-溴尿苷 7,8-二氢-7-甲基鸟苷 5-甲基尿甙 胞磷托定 8-羟基鸟苷 |
| 参考资料 展开查看 | 1. 甄子萱 葛淑俊. 不同产地掌叶半夏中4种核苷类成分和葫芦巴碱测定[J]. 中药材 2017 v.40;No.406(12):85-88. 2. 刘雪莹 赵雨 何慧楠 李雪惠 刘莉 齐滨.不同产地梅花鹿鹿茸药材中5种核苷类成分的含量测定及聚类分析[J].中国药房 2018 29(14):1945-1949. 3. 何慧楠 唐晓雷 刘雨霏 等. 不同加工方法梅花鹿鹿茸中尿嘧啶等五种核苷成分的含量分析[J]. 时珍国医国药 2018 29(10):2395-2397. 4. 刘政波 张亚玉 王秋霞 等. 不同钾水平对人参中核苷类化合物含量的影响[J]. 吉林农业大学学报 2019 41(4):432-437. 5. 梁君 王桁杰 张振凌. 产地加工炮制一体化新工艺对半夏生物碱类成分的影响[J]. 时珍国医国药 2017 028(002):357-359. 6. 孙伟杰, 王铭, 杨洋,等. 基于化学指纹图谱和多指标成分含量测定的梅花鹿鹿茸质量评价[J]. 中华中医药学刊, 2020, v.38(03):196-200. 7. 孙伟杰, 吕程, 杨重晖,等. 基于指纹图谱和多指标定量测定的鹿茸饮片质量控制研究[J]. 中草药, 2019, v.50;No.657(22):65-71. 8. 孔静,贺晶,谭立,申立峰,李倩,张元元,吕珊,武秋红,陈梦杰,刘璐,李文霞,路东波,石任兵,姜艳艳.基于金花葵核苷类成分的质量表征关联分析研究[J].北京中医药大学学报,2017,40(05):420-427 9. 孙伟杰, 刘莉, 齐滨,等. 指纹图谱结合一测多评模式在鹿茸质量评价中的应用[J]. 中国医院药学杂志, 2019, 039(007):698-703. 10. 刘雪莹, 齐滨, 刘雨霏,等. 梅花鹿鹿茸和马鹿鹿茸中5种核苷类成分的含量比较[J]. 中国现代应用药学, 2018, 035(011):1675-1679. 11. 李明波, 段晓蓓, 张海林,等. 超声提取蝉花中核苷碱基的工艺条件[J]. 贵州农业科学, 2014, 000(003):154-157. 12. 张雪婷, 钟承赞, 杨明,等. 金水宝胶囊生产过程中质量控制方法的建立[J]. 中国实验方剂学杂志, 2020(4). 13. 肖云芝, 2], 万露, et al. 鳖甲HPLC指纹图谱的分析模式探讨[J]. 中国实验方剂学杂志, 2015, 21(006):32-36. 14. 代莉莉, 金珊霞, 范梦莹,等. 季铵化β-环糊精接枝壳聚糖涂层用于毛细管电泳分离的研究[J]. 分析试验室, 2017, 08(v.36):15-18. 15. 李学林,王柯涵,康欢,施钧瀚,王青晓,桂新景,张璐,张耀,王艳丽,冯文豪,张璞,姚静,刘瑞新.基于HPLC指纹图谱的黄柏配方颗粒汤剂与标准汤剂、传统汤剂对比研究[J].中草药,2020,51(01):91-100. 16. 马明,张开雪,熊超,邬兰,孙伟,马伟.板蓝根标准汤剂质量标准研究[J].中华中医药杂志,2020,35(10):5139-5144. 17. 王珏,郭钰昕,姚毅,张剑,李津,朱育凤,刘史佳.基于HPLC指纹图谱的半夏及其伪品鉴别研究[J].南京中医药大学学报,2020,36(02):267-272. 18. 陈佳丽,谈梦霞,邹立思,刘训红,陈舒妤,石婧婧,王程成,梅余琪.超快速液相色谱-三重四级杆/线性离子阱质谱法同时测定不同产地竹节参药材中多元成分[J].中国药学杂志,2019,54(03):226-233. 19. 孙慧娟,王瑞,宋芊芊,周慧银,方成武.基于超快速液相色谱-质谱联用技术检测药食两用薄荷中氨基酸和核苷类成分[J].食品与发酵工业,2020,46(08):261-266. 20. 王盼,储全根,轩云,蔡正银.抵当陷胸汤HPLC-MS指纹图谱研究[J].时珍国医国药,2020,31(12):2937-2940. 21. 陆雨顺,王泽帅,毕晓东,夏蕴实,卢思,孙印石.鹿茸饮片浸出物提取方法的建立及多成分测定在质量评价中的应用[J].中草药,2021,52(02):357-366. 22. 刘松鑫,宫瑞泽,王泽帅,张磊,刘畅,陆雨顺,孙印石.基于主成分分析和判别分析对花鹿茸和马鹿茸9类化学成分对比研究[J].中草药,2021,52(01):82-90. 23. Meichen Liu, Yunxia Li, Yunqiu Tang, Li Zheng, Cheng Peng, Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats, Journal of Chromatography 24. Xia, Yuanyuan, et al. "Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics." Journal of Food Composition and Analysis 62 (2017): 134-142.https://doi.org/10.1016 25. Qin Hu, Lu Gao, Sheng-qi Rao, Zhen-quan Yang, Tao Li, Xiaojuan Gong, Nitrogen and chlorine dual-doped carbon nanodots for determination of curcumin in food matrix via inner filter effect, Food Chemistry, Volume 280, 2019, Pages 195-202, ISSN 0308-8146, htt 26. Wen Jie Zhang, Shi Gang Liu, Lei Han, Hong Qun Luo, Nian Bing Li,A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion,Sensors and Ac 27. Wang, Chengcheng, et al. "Distribution patterns for metabolites in medicinal parts of wild and cultivated licorice." Journal of pharmaceutical and biomedical analysis 161 (2018): 464-473.https://doi.org/10.1016/j.jpba.2018.09.004 28. [IF=7.514] Qin Hu et al."Nitrogen and chlorine dual-doped carbon nanodots for determination of curcumin in food matrix via inner filter effect."Food Chem. 2019 May;280:195 29. [IF=7.46] Wen Jie Zhang et al."A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion."Sensor Actuat B-Chem. 2019 Mar;283:215 30. [IF=5.923] Cuihua Chen et al."Variations in Physiology and Multiple Bioactive Constituents under Salt Stress Provide Insight into the Quality Evaluation of Apocyni Veneti Folium."Int J Mol Sci. 2018 Oct;19(10):3042 31. [IF=4.556] Yuanyuan Xia et al."Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics."J Food Compos Anal. 2017 Sep;62:134 32. [IF=4.411] Cuihua Chen et al."Quality Evaluation of Apocyni Veneti Folium from Different Habitats and Commercial Herbs Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Multivariate Statistical Analysis."Molecules. 2018 Mar;23(3):5 33. [IF=4.411] Yujiao Hua et al."Quality Evaluation of Pseudostellariae Radix Based on Simultaneous Determination of Multiple Bioactive Components Combined with Grey Relational Analysis."Molecules. 2017 Jan;22(1):13 34. [IF=2.896] Ya-yun Chen et al."Determination of free amino acids and nucleosides and nucleobases in Annona squamosa L. fruitages from different regions in China by LC-QTRAP-MS/MS."Anal Methods-Uk. 2017 Jun;9(25):3862-3869 35. [IF=1.618] Li Yan et al."Simultaneous Determination and Comparative Pharmacokinetics of Fuzi Water-Soluble Alkaloids between Normal and Acute Heart Failure Rats by Ultra Performance Liquid Chromatography Method."J Chromatogr Sci. 2017 Aug;55(7):719-728 36. [IF=6.986] Yu-Fang Ma et al."Synthesis of a pH-Responsive Functional Covalent Organic Framework via Facile and Rapid One-Step Postsynthetic Modification and Its Application in Highly Efficient N1-Methyladenosine Extraction."Anal Chem. 2020;92(1):1424–1430 37. [IF=4.411] Mengxia Tan et al."Quality Evaluation of Ophiopogonis Radix from Two Different Producing Areas."Molecules. 2019 Jan;24(18):3220 38. [IF=4.411] Shengxin Yin et al."Comparison of Multiple Bioactive Constituents in the Corolla and Other Parts of Abelmoschus manihot."Molecules. 2021 Jan;26(7):1864 39. [IF=4.27] Cuihua Chen et al."Metabolomics characterizes metabolic changes of Apocyni Veneti Folium in response to salt stress."Plant Physiol Bioch. 2019 Nov;144:187 40. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 41. [IF=3.004] Meichen Liu et al."Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats."J Chromatogr B. 2020 Jan;1137:121935 42. [IF=1.618] Wang Shengnan et al."Simultaneous Determination of Iridoid Glycosides, Phenylpropanoid Glycosides, Organic Acids, Nucleosides and Amino Acids in Scrophulariae Radix Processed by Different Processing Methods by HPLC-QTRAP-MS/MS."J Chromatogr Sci. 2021 Jun; 43. [IF=6.529] Yarigui Bao et al."Therapeutic effects of Chinese medicine Di-Long (Pheretima vulgaris) on rheumatoid arthritis through inhibiting NF-κB activation and regulating Th1/Th2 balance."Biomed Pharmacother. 2022 Mar;147:112643 44. [IF=4.411] Nan Wu et al."Quality Evaluation of Taxilli Herba from Different Hosts Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Multivariate Statistical Analysis."Molecules. 2021 Jan;26(24):7490 |
供应商列表
鸟苷的下游产品
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！