(1-硫-Β-D-吡喃葡糖络)(三乙基膦)金-2,3,4,6-四乙酸酯
金诺芬(AURANOFIN)
CAS: 34031-32-8
化学式: C20H34AuO9PS
| 中文名 | 金诺芬 |
| 英文名 | AURANOFIN |
| 别名 | 金诺芬 醋硫葡金 (1-硫-Β-D-吡喃葡糖络)(三乙基膦)金-2,3,4,6-四乙酸酯 2,3,4,6-四乙酰氧基-1-硫代-beta-D-吡喃葡萄糖(三乙基磷)金盐 2,3,4,6-四乙酰氧基-1-硫代-beta-D-吡喃葡萄糖(三乙基磷)金盐 ((2S,3R,4S,5R,6R)-3,4,5-三乙酰氧基-6-(乙酰氧基甲基)四氢-2H-吡喃-2-硫基)(三乙基膦)金 |
| 英文别名 | Auranon ridaura Auranofin AURANOFIN AURANOFINE gold(+1) cation triethylphosphonium 3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydropyran-2-thiolate gold,(1-thio-beta-d-glucopyranose2,3,4,6-tetraacetato-s)(triethylphosphine) (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate |
| CAS | 34031-32-8 |
| EINECS | 251-801-9 |
| 化学式 | C20H34AuO9PS |
| 分子量 | 678.48 |
| InChI | InChI=1/C6H15P.Au/c1-4-7(5-2)6-3;/h4-6H2,1-3H3;/q;+1 |
| 熔点 | 112-115° |
| 溶解度 | DMSO: ≥ 5 mg/mL |
| 存储条件 | room temp |
| 稳定性 | 从提供的购买之日起稳定2年。在DMSO或乙醇中的溶液可以在-20 ° 储存长达2个月。 |
| 外观 | 固体 |
| 颜色 | Crystals |
| 物化性质 | 无色结晶，熔点110-111℃，[α]D23-55.3°(C=1，甲醇)。急性毒性LD50大鼠，小鼠(mg/kg)：265，310 口服。 |
| 靶点 | TrxR |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | R63 - 可能有对胎儿造成伤害的危险。 R22 - 吞食有害。 |
| 安全术语 | 36/37 - 穿戴适当的防护服和手套。 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| RTECS | MD6500000 |
| 上游原料 | 三乙基膦 硫代二甘醇 碳酸钾 |
| 参考资料 展开查看 | 1: Fuchs BB, RajaMuthiah R, Souza AC, Eatemadpour S, Rossoni RD, Santos DA, Junqueira JC, Rice LB, Mylonakis E. Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin. Future Med Chem. 2016;8(2):117-32. doi: 10.4155/fmc.15.182. PubMed PMID: 26808006; PubMed Central PMCID: PMC4976847. 2: Oommen D, Yiannakis D, Jha AN. BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin. Mutat Res. 2016 Feb-Mar;784-785:8-15. doi: 10.1016/j.mrfmmm.2015.11.002. PubMed PMID: 26731315. 3: Gamberi T, Fiaschi T, Modesti A, Massai L, Messori L, Balzi M, Magherini F. Evidence that the antiproliferative effects of auranofin in Saccharomyces cerevisiae arise from inhibition of mitochondrial respiration. Int J Biochem Cell Biol. 2015 Aug;65:61-71. doi: 10.1016/j.biocel.2015.05.016. PubMed PMID: 26024642. 4: You BR, Park WH. Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion. Oncol Rep. 2016 Jan;35(1):546-51. doi: 10.3892/or.2015.4382. PubMed PMID: 26530353. 5: Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR Jr, Schultz PG, Wang F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4453-8. doi: 10.1073/pnas.1504022112. PubMed PMID: 25831516; PubMed Central PMCID: PMC4394260. 6: He MF, Gao XP, Li SC, He ZH, Chen N, Wang YB, She JX. Anti-angiogenic effect of auranofin on HUVECs in vitro and zebrafish in viv |
(1-硫-Β-D-吡喃葡糖络)(三乙基膦)金-2,3,4,6-四乙酸酯 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.474 ml | 7.369 ml | 14.739 ml |
| 5 mM | 0.295 ml | 1.474 ml | 2.948 ml |
| 10 mM | 0.147 ml | 0.737 ml | 1.474 ml |
| 5 mM | 0.029 ml | 0.147 ml | 0.295 ml |
最后更新：2024-01-02 23:10:35
(1-硫-Β-D-吡喃葡糖络)(三乙基膦)金-2,3,4,6-四乙酸酯 - 细胞实验
Auranofin is dissolved in DMSO. Cells are treated with auranofin (0, 50, 100, 200 and 400 nM) for 72 h for the dose-dependent response assay and 100 nM of auranofin is added into the wells for 0, 24, 72 and 120 h for the time-dependent response assay. Control cultures are treated with DMSO. Cell viability is measured by the MTT assay.
最后更新：2023-08-16 21:32:38
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产品名: ((2S,3R,4S,5R,6R)-3,4,5-三乙酰氧基-6-(乙酰氧基甲基)四氢-2H-吡喃-2-硫基)(三乙基膦)金 去供应商网站查看 询盘CAS: 34031-32-8
产地: 北京
包装: 瓶
规格: YS100148-250mg,YS100148-1g,YS100148-100mg
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库存: 一周左右
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提供多种规格现货供应
产品名: ((2S,3R,4S,5R,6R)-3,4,5-三乙酰氧基-6-(乙酰氧基甲基)四氢-2H-吡喃-2-硫基)(三乙基膦)金 去供应商网站查看 询盘CAS: 34031-32-8
产地: 北京
包装: 瓶
规格: YS100148-250mg,YS100148-1g,YS100148-100mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
(1-硫-Β-D-吡喃葡糖络)(三乙基膦)金-2,3,4,6-四乙酸酯的上游原料
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