中文名 | 1-(3,4-二甲氧基苯乙基)-4-(3-苯丙基)哌嗪双盐酸盐 |
英文名 | 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride |
别名 | 库他美新二盐酸盐 1-(3,4-二甲氧基苯乙基)-4-(3-苯丙基)哌嗪双盐酸盐 1-(3,4-二甲氧基苯乙基)-4-(3-苯基丙基)哌嗪双盐酸盐 1-[2-(3,4-二甲氧基苯基)乙基]-4-(3-苯基丙基)哌嗪盐酸盐 |
英文别名 | SA-4503 Sa-4503 SA-4503(2HCl) SA 4503 (dihydrochloride) Cutamesine HCl (SA-4503 HCl) 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazinedihydrochloride 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine hydrochloride 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride 1-[2-(3,4-DiMethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE |
CAS | 165377-44-6 |
化学式 | C23H32N2O2.2ClH |
分子量 | 441.44 |
InChI | InChI=1/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H |
熔点 | 250-252°C |
沸点 | 499.2°C at 760 mmHg |
闪点 | 137.3°C |
蒸汽压 | 4.25E-10mmHg at 25°C |
溶解度 | 溶于DMSO (高达5 mg/ml) 或水 (高达至少25 mg/ml)。 |
存储条件 | 2-8°C |
稳定性 | 从提供的购买之日起稳定1年。DMSO或蒸馏水中的溶液可以在-20 ° 下储存长达1个月。 |
外观 | 粉末 |
颜色 | white to beige |
体外研究 | The sigma receptor might be involved in several diseases in the central nervous system. Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC 50 =17.4 nM) than σ2 (IC 50 =1,784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (K i =4.6 nM) over σ2 (K i =63.1 nM) sites in guinea pig brain homogenates. Cutamesine protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2. Cutamesine reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1. |
体内研究 | Cutamesine extends the survival time in the SOD1G93A mice. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.265 ml | 11.327 ml | 22.653 ml |
5 mM | 0.453 ml | 2.265 ml | 4.531 ml |
10 mM | 0.227 ml | 1.133 ml | 2.265 ml |
5 mM | 0.045 ml | 0.227 ml | 0.453 ml |
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